Abstract:
:Repeated stress triggers a wide range of adaptive changes in the central nervous system including the elevation of serotonin (5-HT) metabolism and an increased susceptibility to affective disorders. To begin to examine whether these changes are mediated by alterations in gene expression for tryptophan hydroxylase (TPH), the rate-limiting enzyme in 5-HT biosynthesis, we quantitated its mRNA levels by competitive reverse transcription-polymerase chain reaction (RT-PCR). Repeated immobilization stress (2 h, 7 days) elicited a six- or ten-fold rise in TPH mRNA in median raphe nucleus (MRN) and dorsal raphe nucleus (DRN), respectively, without significantly altering TPH mRNA levels in the pineal gland. In contrast, there was little change in mRNA levels for GTP cyclohydrolase I (GTPCH), the rate limiting enzyme in synthesis of the tetrahydrobiopterin (BH4), the obligate cofactor for TPH. This is the first study to reveal stress-elicited activation of TPH gene expression.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Chamas F,Serova L,Sabban ELdoi
10.1016/s0304-3940(99)00340-7keywords:
subject
Has Abstractpub_date
1999-06-04 00:00:00pages
157-60issue
3eissn
0304-3940issn
1872-7972pii
S0304394099003407journal_volume
267pub_type
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