Abstract：
:The interaction of NMDA receptor (NMDAR) activation and other mechanisms regulating neuronal excitability have not been thoroughly described. While excess activation of NMDARs results in excitotoxicity, partial activation of NMDARs by d-cycloserine (DCS) is nootropic, enhancing both acquisition and extinction of memories. The mechanism by which DCS treatment enhances memory is unclear. NMDAR activation has been shown to increase expression of the activity-regulated cytoskeletal (Arc) protein associated with neural plasticity and enhanced memory. Enhanced memory is also associated with increases in neuronal intrinsic excitability, i.e. reductions in post-burst afterhyperpolarizations (AHPs) after acquisition of new tasks. Reductions in AHPs can occur when Ca(2+) influx is reduced. This study aimed to determine if either if Arc expression, intrinsic excitability, or both were altered following systemic administration of a memory-enhancing dose of DCS, i.e. what form of plasticity would be exhibited. Both Arc protein expression and intrinsic excitability were enhanced in tissue prepared 1h post-administration of a nootropic dose of DCS. Both mechanisms have been strongly associated with memory enhancement, but have not previously been demonstrated to change across the same time frame in the same preparation in response to DCS treatment.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Donzis EJ,Thompson LTdoi
10.1016/j.neulet.2014.04.035subject
Has Abstractpub_date
2014-06-13 00:00:00pages
50-4eissn
0304-3940issn
1872-7972pii
S0304-3940(14)00346-2journal_volume
571pub_type
杂志文章abstract：:Using antibodies to somatostatin in combination with the avidin-biotin immunohistochemical method, the laminar distribution and morphology of somatostatin-like (SOM-L) immunoreactive cells have been studied in the hippocampal formation of the rat. SOM-L positive cells are present throughout the longitudinal axis of th...
journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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更新日期：1994-02-28 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2011-04-08 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2007-01-16 00:00:00
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journal_title：Neuroscience letters
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doi：10.1016/j.neulet.2004.11.055
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journal_title：Neuroscience letters
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doi：10.1016/0304-3940(85)90350-7
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2001-06-22 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2010-04-05 00:00:00
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journal_title：Neuroscience letters
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更新日期：2018-03-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90667-8
更新日期：1989-05-22 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)12192-7
更新日期：1995-12-29 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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