Abstract:
:Hyperactivity of the hypothalamic-pituitary-adrenal axis is associated with depression. We investigated the effect of various types of antidepressant agents in vitro on the function of glucocorticoid receptor (GR). Desipramine, clomiplamine, fluoxetine, milnacipran and clorgyline all induced rapid and sustained translocation of GR into the nucleus of human lymphocytes. In contrast, major and minor tranquilizers, lithium and verapamil, a blocker of membrane steroid transporter, were without effect. These antidepressants did not affect GR-mediated transcription by themselves, but significantly inhibited dexamethasone-induced transcription. These results indicate that structurally different antidepressants induce translocation of GR and inhibit GR-mediated transcription.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Okuyama-Tamura M,Mikuni M,Kojima Idoi
10.1016/s0304-3940(03)00261-1keywords:
subject
Has Abstractpub_date
2003-05-22 00:00:00pages
206-10issue
3eissn
0304-3940issn
1872-7972pii
S0304394003002611journal_volume
342pub_type
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