Ibotenate stimulates glutamate release from guinea pig cerebrocortical synaptosomes: inhibition by L-2-amino-4-phosphonobutyrate (L-AP4).

Abstract:

:Ibotenate induced a concentration- and largely calcium-dependent release of endogenous glutamate from guinea pig cerebro-cortical synaptosomes. In the absence of Mg2+, the response to ibotenate was enhanced through a mechanism involving N-methyl-D-aspartate (NMDA) receptors; this component was sensitive to the NMDA antagonist 2-amino-7-phosphonoheptanoate (AP7). In the presence of Mg2+, the ibotenate-induced Ca2(+)-dependent release was abolished by L-2-amino-4-phosphonobutyrate (L-AP4). It is suggested that presynaptic 'L-AP4 receptors' exist in guinea pig cerebral cortex, at which ibotenate acts to facilitate glutamate release. L-AP4 may act as an antagonist, or partial agonist of weak intrinsic activity.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Jones PG,Roberts PJ

doi

10.1016/0304-3940(90)90373-h

subject

Has Abstract

pub_date

1990-03-26 00:00:00

pages

228-32

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(90)90373-H

journal_volume

111

pub_type

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