Abstract:
:Ibotenate induced a concentration- and largely calcium-dependent release of endogenous glutamate from guinea pig cerebro-cortical synaptosomes. In the absence of Mg2+, the response to ibotenate was enhanced through a mechanism involving N-methyl-D-aspartate (NMDA) receptors; this component was sensitive to the NMDA antagonist 2-amino-7-phosphonoheptanoate (AP7). In the presence of Mg2+, the ibotenate-induced Ca2(+)-dependent release was abolished by L-2-amino-4-phosphonobutyrate (L-AP4). It is suggested that presynaptic 'L-AP4 receptors' exist in guinea pig cerebral cortex, at which ibotenate acts to facilitate glutamate release. L-AP4 may act as an antagonist, or partial agonist of weak intrinsic activity.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Jones PG,Roberts PJdoi
10.1016/0304-3940(90)90373-hsubject
Has Abstractpub_date
1990-03-26 00:00:00pages
228-32issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(90)90373-Hjournal_volume
111pub_type
杂志文章abstract::Rat cerebral explants were cultured in the presence or absence of the mitotic inhibitor cytosine arabinoside (AraC) to investigate whether reports of increased neurite outgrowth may be primarily related to a decreased incidence of fibroblastic-reactive microglial cells. Treated explants were exposed to AraC from 7 to ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90101-8
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90501-0
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.09.050
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12972-4
更新日期:1996-09-13 00:00:00
abstract::This article has been withdrawn at the request of the Editor-in-Chief. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...
journal_title:Neuroscience letters
pub_type: 撤回出版物
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.10.075
更新日期:2012-01-11 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2004-11-11 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2010-03-12 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1990-07-03 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2010.06.060
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90205-y
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