Abstract:
:Amyloid beta (A beta) is a normal proteolytic fragment of a large precursor protein (beta PP) which undergoes altered conformation, leading to fibril formation. Two main beta PP processing pathways have been described, and we are now reporting the characterization of a third beta PP pathway. A membrane-associated 16 kDa component identified in human platelets isolated from normal donors. Based on size, immunoreactivity and amino acid sequence analysis, the fragment is a C-terminal beta PP component which starts at position 642 (APP770 numbering) and contains the intact A beta sequence. The presence of this novel pathway of beta PP processing in resting platelets suggest that it occurs as a normal event.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ghiso J,Gardella JE,Liem L,Gorevic PD,Frangione Bdoi
10.1016/0304-3940(94)90642-4subject
Has Abstractpub_date
1994-04-25 00:00:00pages
213-6issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(94)90642-4journal_volume
171pub_type
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journal_title:Neuroscience letters
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