Proteasomal function is impaired in substantia nigra in Parkinson's disease.

abstract：:The isthmo-optic system is less developed in birds feeding-on-the-wing, than in pecking avians. This was suggested previously. By intraocular horseradish peroxidase applications, we studied the central origin of this retino-petal system in thrush, haw finch, swift and swallow. Our data support the assumption on a corr...

journal_title：Neuroscience letters

authors： Feyerabend B,Malz CR,Meyer DL

更新日期：1994-11-21 00:00:00

abstract：:The present study shows that cultured fibroblasts from sporadic Alzheimer's disease patients are deficient in protein kinase C-regulated secretion of amyloid precursor protein. In particular, Alzheimer fibroblasts show a reduced basal secretion and a reduced response at low concentrations of phorbol-12,13-dibutyrate, ...

journal_title：Neuroscience letters

authors： Bergamaschi S,Binetti G,Govoni S,Wetsel WC,Battaini F,Trabucchi M,Bianchetti A,Racchi M

更新日期：1995-12-01 00:00:00

abstract：:In recent years, several attempts have been made to identify biochemical and/or genetic markers which might have diagnostic and prognostic uses for Alzheimer's disease (AD). To look for possible new blood markers, a longitudinal study was carried out in our Central Nervous System Biomedical Research Center between Oct...

journal_title：Neuroscience letters

authors： Lombardi VR,Cacabelos R

更新日期：1999-01-22 00:00:00

abstract：:We have used Lucifer Yellow for histological tracing of displaced amacrine cells within the ganglion cell layer (GCL) during the embryonic development of the chicken retina. Incubating whole eyes in the dye leads to bright staining of all displaced amacrine cells, whereas ganglion cells and glial cells are not stained...

journal_title：Neuroscience letters

authors： Layer PG,Vollmer G

更新日期：1982-08-16 00:00:00

abstract：:The brains of 7 dogs aged 6 to 18 years have been histochemically and immunohistochemically investigated at the light- and electron microscopy levels for preamyloid deposits and amyloid fibrils to verify the hypothesis that the accumulation of cleavage products of amyloid precursor protein is related not only to Alzhe...

journal_title：Neuroscience letters

authors： Giaccone G,Verga L,Finazzi M,Pollo B,Tagliavini F,Frangione B,Bugiani O

更新日期：1990-07-03 00:00:00

abstract：:Recently, our group described the ether-à-go-go1(Eag1) voltage-gated potassium (K(+)) channel (Kv10.1) expression in the dopaminergic cells indicating that these channels are part of the diversified group of ion channels related to dopaminergic neurons function. The increase of dopamine neurotransmission induces a red...

journal_title：Neuroscience letters

authors： Issy AC,Fonseca JR,Pardo LA,Stühmer W,Del Bel EA

更新日期：2014-01-24 00:00:00

abstract：:The K variant of the butyrylcholinesterase gene (BChE) was recently found to occur at an increased frequency in a late onset Alzheimer's disease (AD) population, specifically in individuals carrying the epsilon4 allele of the apolipoprotein E (APOE) gene. This suggested synergy between these two genes resulting in an ...

journal_title：Neuroscience letters

authors： Crawford F,Fallin D,Suo Z,Abdullah L,Gold M,Gauntlett A,Duara R,Mullan M

更新日期：1998-06-19 00:00:00

abstract：:The psychostimulant amphetamine (AMPH) is known to act as an indirect dopamine agonist by promoting dopamine release. Here we demonstrate direct AMPH inhibition of field potentials and Na+ currents in rat nucleus accumbens (NAc) neurons. The experiments were done with field potential recordings from NAc slices and who...

journal_title：Neuroscience letters

authors： Huang RC,Lin JY

更新日期：1998-08-07 00:00:00

abstract：:Ovariectomy in the rat abolishes alpha-bungarotoxin (alpha-BTX) binding within the suprachiasmatic nucleus (SCN), a putative circadian pacemaker, and markedly reduces cholinergic activation of SCN cells. Circadian rhythms of running wheel activity were monitored continuously in intact male and female and chronically o...

journal_title：Neuroscience letters

authors： Mistlberger RE,Rusak B

更新日期：1986-12-23 00:00:00

abstract：:Quantitative in vitro receptor autoradiography was used to examine the effect of acute scopolamine administration on specific binding to components of the N-methyl-D-aspartate (NMDA) receptor complex in four regions of mouse hippocampus. The binding of [3H]glycine to the strychnine-insensitive site was increased 1 h a...

journal_title：Neuroscience letters

authors： Deutsch SI,Panchision DM,Rosse RB,Novitzki MR,Miller LP,Mastropaolo J

更新日期：1990-10-02 00:00:00

abstract：:The ergoline derivatives, nicergoline (NIC) or dihydroergocristine (DHE) were administered at various doses (0.1, 0.5 and 1 mg/kg) to aged male rats subjected to labyrinth unilateral lesion (LBX). The nystagmus rate appeared to be lower in animals treated with DHE or NIC 1mg/kg than in saline-injected rats, when obser...

journal_title：Neuroscience letters

authors： Rampello L,Drago F

更新日期：1999-05-28 00:00:00

abstract：:Opioid-cholecystokinin (CCK) interactions at the spinal level were investigated by looking for possible modulations by various opioid agonists of the release of cholecystokinin-like material (CCKLM) from slices of the dorsal zone of the rat lumbar enlargement. K(+)-evoked CCKLM overflow was reduced by 0.1-10 microM of...

journal_title：Neuroscience letters

authors： Benoliel JJ,Bourgoin S,Mauborgne A,Legrand JC,Hamon M,Cesselin F

更新日期：1991-04-01 00:00:00

abstract：:Morphine blocked decremental bar pressing of rats to escape electrical stimulation of aversive midbrain sites. These sites included the dorsal central gray area (DCG), the ventral reticular formation (VRF) and the lateral tegmentum (LT). Naloxone, which had no effect alone, blocked the morphine effects of all three av...

journal_title：Neuroscience letters

authors： Kiser RS,German DC

更新日期：1978-11-01 00:00:00

abstract：:'Clipsin' and other peptide bond hydrolase activities that appear to be integral membrane proteins, including two implicated in the formation of the histological hallmarks of Alzheimer's disease, were assayed in the frontal and parietal cortex from a large (n = 45) series of postmortem human brains. Tissues were extra...

journal_title：Neuroscience letters

authors： Stratmann GC,Webster MT,Francis PT,Procter AW,Bowen DM

更新日期：1992-08-31 00:00:00

abstract：:The mental rotation (MR) task is defined as a discrimination task between mirror-reversed images involving discrepancy in angular orientation. Various studies have shown that the MR task likely causes mental imagery, that is, visual and/or motor imagery, depending on stimulus types. When figures of rotated hands are p...

journal_title：Neuroscience letters

authors： Meng S,Oi M,Sekiyama K,Saito H

更新日期：2016-08-03 00:00:00

abstract：:Our previous studies showed that corticospinal excitability during imagery of squeezing a foam ball was enhanced by somatosensory input generated by passively holding the ball. In the present study, using the same experimental model, we investigated whether corticospinal excitability was influenced by holding the obje...

journal_title：Neuroscience letters

authors： Mizuguchi N,Sakamoto M,Muraoka T,Moriyama N,Nakagawa K,Nakata H,Kanosue K

更新日期：2012-04-11 00:00:00

abstract：:[3H]Glibenclamide, a potent ATP-sensitive K+ channel blocker, is a specific ligand for the identification of the sulfonylureas receptors which are closely related to ATP-sensitive K+ channels. In order to determine the pre- or postsynaptic localization of these receptors in the rat hippocampus, we studied the effects ...

journal_title：Neuroscience letters

authors： Tremblay E,Zini S,Ben-Ari Y

更新日期：1991-06-10 00:00:00

abstract：:Early onset generalized dystonia is a dominantly inherited movement disorder caused by neuronal dysfunction without an apparent loss of neurons. The same single mutation (GAG deletion) causes most cases and results in loss of a glutamic acid (E) in the carboxy terminal region of torsinA (Delta302/303). To model the ne...

journal_title：Neuroscience letters

authors： Kock N,Allchorne AJ,Sena-Esteves M,Woolf CJ,Breakefield XO

更新日期：2006-03-13 00:00:00

abstract：:The present study was designed to test the hypothesis that acute administration of alcohol (ethanol) to primary cultured cerebral vascular smooth muscle cells will cause lipid peroxidation, inhibition of IkappaB phosphorylation, and inhibition of nuclear transcription factor-kappa B (NF-kappaB). Ethanol (10, 25, 100 m...

journal_title：Neuroscience letters

authors： Altura BM,Gebrewold A,Zhang A,Altura BT

更新日期：2002-06-07 00:00:00

abstract：:We have investigated the presence of mutations in the parkin gene in patients with early-onset parkinsonism. Direct sequencing of the polymerase chain reaction (PCR) products showed a homozygous G deletion in the exon 7 (c.871delG) in one patient. This was a 38-year-old Moroccan woman with a history of parkinsonism of...

journal_title：Neuroscience letters

authors： Muñoz E,Pastor P,Martí MJ,Oliva R,Tolosa E

更新日期：2000-07-28 00:00:00

abstract：:We have reported that an arousal response accompanied by yawning behavior can be evoked by electrical and chemical stimulation of the hypothalamic paraventricular nucleus (PVN) in rats, although the mechanism responsible for the arousal response accompanied by yawning evoked by PVN stimulation is still unknown. In the...

journal_title：Neuroscience letters

authors： Kita I,Kubota N,Yanagita S,Motoki C

更新日期：2008-03-15 00:00:00

abstract：:Coenzyme Q(10) (CoQ(10)) exerts neuroprotective effects in several in vivo and in vitro models of neurodegenerative disorders. However, the mechanisms of action are not fully understood. The aim in this study was to investigate whether oral administration of CoQ(10) could inhibit cytochrome c (cyt c) release from mito...

journal_title：Neuroscience letters

authors： Mitsumoto Y,Kobayashi S,Matsushima H,Muroyama A,Yoshimura I

更新日期：2009-09-29 00:00:00

abstract：:Rabbit retinal Müller cells were isolated by means of papaine and mechanical dissociation. These cells were shown to have a well preserved morphology and to preserve viability for many hours. Intense wheat germ agglutinin binding occurs on the photoreceptor side of Müller cells, especially in the microvillous region. ...

journal_title：Neuroscience letters

authors： Reichenbach A,Dettmer D,Brückner G,Neumann M,Birkenmeyer G

更新日期：1985-03-22 00:00:00

abstract：:Several studies on the relationship between event-related desynchronization/synchronization (ERD/ERS) and cognitive performance revealed contradictory results particularly for the alpha band. Studies from our laboratory have shown that good performers show a larger upper alpha ERD (interpreted in terms of larger corti...

journal_title：Neuroscience letters

authors： Doppelmayr M,Klimesch W,Sauseng P,Hödlmoser K,Stadler W,Hanslmayr S

更新日期：2005-06-24 00:00:00

abstract：:Patients with unilateral (n = 14) and bilateral (n = 4) herniorrhaphy participated in this study. With bilateral herniorrhaphy, at the end of the surgery, the wound was infiltrated with a solution of bupivacaine 0.5% and ketamine 0.3% on one side and a solution of bupivacaine 0.5% only, on the other. With unilateral h...

journal_title：Neuroscience letters

authors： Tverskoy M,Oren M,Vaskovich M,Dashkovsky I,Kissin I

更新日期：1996-08-30 00:00:00

abstract：:Research indicates that threat-induced changes in standing balance are associated with shifts in attention focus. This study investigated whether distracting attention modifies threat-induced changes in standing balance. Twenty-five healthy young adults stood without (No Threat) and with (Threat) the possibility of re...

journal_title：Neuroscience letters

authors： Johnson KJ,Watson AM,Tokuno CD,Carpenter MG,Adkin AL

更新日期：2020-01-18 00:00:00

abstract：:The possible involvement of 2-amino-4-phosphonobutyrate (APB) recognition sites in mechanisms enabling the maintenance of long-term potentiation (LTP) was investigated in rat hippocampal slices. The action of D(-)- and L(+)-isomers of APB was tested on orthodromic EPSP and spike responses recorded extracellularly from...

journal_title：Neuroscience letters

authors： Reymann KG,Matthies H

更新日期：1989-03-27 00:00:00

abstract：:RE-1 silencer transcription factor (REST), also known as neuron-restrictive silencer factor (NRSF), contains nine Cys2-His2 type zinc finger domains (ZFDs). REST/NRSF is localized to the nucleus, where it represses the transcriptional activity of a large number of neuronal genes in non-neuronal cells. It has been sugg...

journal_title：Neuroscience letters

authors： Shimojo M

更新日期：2006-05-08 00:00:00

abstract：:Calcium homeostasis in synaptosomes is altered during ageing. The cytosolic free calcium concentration, [Ca2+]i was determined in synaptosomes and crude synaptosomal fractions from 3- and 24-month-old rats with the fluorescent indicator quin-2. The [Ca2+]i were around two times higher in 24-month-old rats than in adul...

journal_title：Neuroscience letters

authors： Martinez A,Vitórica J,Satrústegui J

更新日期：1988-06-07 00:00:00

abstract：:The optic nerve (ON) in adult rats was transected intraorbitally followed by retrograde labelling of retinal ganglion cells (RGCs) with fluorescence dye (DiI). A two phase reduction of axotomized RGCs was represented in the retina until 15 days after ON transection. The critical period of RGC loss is around 7 days aft...

journal_title：Neuroscience letters

authors： Takano M,Horie H

更新日期：1994-07-04 00:00:00