Autoradiographic study of the cellular localization of [3H]glibenclamide binding sites in the rat hippocampus.

abstract：:Capsaicin, a neurotoxin which impairs some primary afferent nerve fibers, was locally applied to the mesenteric nerve trunks of adult guinea pigs. The effect of capsaicin was studied on contractile responses of the ileum to mesenteric nerve stimulation (20 Hz). Exposure of the mesenteric nerve to capsaicin (1 microM) ...

journal_title：Neuroscience letters

authors： Jin JG,Takaki M,Nakayama S

更新日期：1989-11-20 00:00:00

abstract：:To investigate changes in regional cerebral blood flow (rCBF) under the prone condition with and without light massage on the back, we measured rCBF quantitatively in healthy human subjects using positron emission tomography with H(2)15O. Biochemical tests showed that the light massage (palm-pressure) reduced levels o...

journal_title：Neuroscience letters

authors： Ouchi Y,Kanno T,Okada H,Yoshikawa E,Shinke T,Nagasawa S,Minoda K,Doi H

更新日期：2006-10-23 00:00:00

abstract：:Cortical spreading depression (SD) may produce some symptoms of the aura of classical migraine but it is less probable that it can account for the headache. The aversiveness of SD was examined in unanesthetized rats. In Exp. 1, rats with implanted cortical cannulae were confined in the dark compartment of the step-thr...

journal_title：Neuroscience letters

authors： Koroleva VI,Bures J

更新日期：1993-01-12 00:00:00

abstract：:By using intracellular deposition of horseradish peroxidase (HRP), a method has been designed for combined light and electron microscopic tracing of single fibers and synaptic terminals, belonging to physiologically characterized neurons. This technique has been successfully tested on the axon collateral systems of ca...

journal_title：Neuroscience letters

authors： Cullheim S,Kellerth JO

更新日期：1976-08-01 00:00:00

abstract：:Hypoxic preconditioning (HP) is a novel strategy to make stem cells resistant to the ischemic environment they encounter after transplantation into injured tissue; this strategy improves survival of both the transplanted cells and the host cells at the injury site. Using both in vitro and in vivo injury models, we con...

journal_title：Neuroscience letters

authors： Oh JS,Ha Y,An SS,Khan M,Pennant WA,Kim HJ,Yoon DH,Lee M,Kim KN

更新日期：2010-03-26 00:00:00

abstract：:The effect of 5-hydroxytryptamine on the spontaneous activity of neurons of the subthalamic nucleus was examined by recording the extracellular unitary activity in an in vitro slice preparation. The most frequent response to 5-hydroxytryptamine (84% of 57 neurons tested) was an increase (twofold of basal at 10 microM)...

journal_title：Neuroscience letters

authors： Flores G,Rosales MG,Hernández S,Sierra A,Aceves J

更新日期：1995-06-02 00:00:00

abstract：:Using frozen-thawed and extensively washed rat cortical membranes, the effects of 3-((+/-)2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) on [3H]N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine ([3H]TCP) binding stimulated by either 1 microM L-glutamate or 300 microM Mg2+ were examined. CPP much more potently inhibit...

journal_title：Neuroscience letters

authors： Hatta K,Yamamato T,Hori T,Okuwa M,Moroji T

更新日期：1991-04-01 00:00:00

abstract：:The contribution of excitatory inputs to CA1 pyramidal cell death after ischemia was examined using rats with unilateral destruction of CA3 pyramidal cells. Intracerebroventricular injection of L-alpha-kainic acid (KA) was performed before the induction of transient forebrain ischemia. Five days after ischemic insult,...

journal_title：Neuroscience letters

authors： Onodera H,Sato G,Kogure K

更新日期：1986-07-24 00:00:00

abstract：:A non-calcium-dependent chloride channel of conductance 62 pS, found in isolated inside-out patches of cultured fetal rat hippocampal neurons, is described. The channel does not require the presence of any neurotransmitter to be active and probably plays a part in maintaining the normal resting membrane potential. ...

journal_title：Neuroscience letters

authors： Shukla H,Pockett S

更新日期：1990-05-04 00:00:00

abstract：:The effects of maternal deprivation (MD) during early postnatal life on the brain-derived neurotrophic factor (BDNF) level were investigated in the present study. Wistar rats were assigned to either maternal deprivation or mother-reared control (MRC) groups. MD manipulation was achieved by separating rat pups from the...

journal_title：Neuroscience letters

authors： Kuma H,Miki T,Matsumoto Y,Gu H,Li HP,Kusaka T,Satriotomo I,Okamoto H,Yokoyama T,Bedi KS,Onishi S,Suwaki H,Takeuchi Y

更新日期：2004-11-30 00:00:00

abstract：:Purinoceptor agonists produced potassium currents with the order of potency: ATP > adenosine = ADP = AMP > beta,gamma-methylene ATP, while a small response or no response was induced by 2-methylthio ATP, UTP, or alpha,beta-methylene ATP. The response induced by beta,gamma-methylene ATP was completely inhibited in the ...

journal_title：Neuroscience letters

authors： Matsuoka T,Nishizaki T,Nomura T,Mori M,Okada Y

更新日期：1998-05-29 00:00:00

abstract：:Vanilloid receptors are activated by capsaicin, the pungent ingredient in hot pepper. They are also specifically and competitively inhibited by capsazepine (CPZ). To determine whether CPZ is specific to vanilloid receptors, its effects were tested on the currents evoked by nicotine in rat trigeminal ganglia. We found ...

journal_title：Neuroscience letters

authors： Liu L,Simon SA

更新日期：1997-05-30 00:00:00

abstract：:We studied the extracellular concentration of glutamate and taurine in the frontal cortex of freely-moving pentylenetetrazole (PTZ) kindled rats using an in vivo microdialysis. A significant and sustained increase in the glutamate level was observed in the kindled rats, in contrast, a slight and delayed increase was o...

journal_title：Neuroscience letters

authors： Li Z,Yamamoto Y,Morimoto T,Ono J,Okada S,Yamatodani A

更新日期：2000-03-17 00:00:00

abstract：:Statins were recently shown to possess anti-inflammatory activities, which might be responsible for their favourable effects in cardiovascular or CNS disorders independently from the inhibition of hydroxy-methyl-glutaryl CoA reductase. Here we investigated the effects of the statins lovastatin and mevastatin on prosta...

journal_title：Neuroscience letters

authors： Tringali G,Vairano M,Dello Russo C,Preziosi P,Navarra P

更新日期：2004-01-09 00:00:00

abstract：:Cyclins are regulatory proteins of the cell cycle which bind and activate kinases. In gliomas, contrary to many malignancies, cyclin D1 is rarely amplified, but together with other cyclins, it increases with anaplasia. In a series of 23 surgical biopsies of grade II and III oligodendroglioma, cyclin D1, E, A, B1, CDK4...

journal_title：Neuroscience letters

authors： Fiano V,Ghimenti C,Schiffer D

更新日期：2003-08-21 00:00:00

abstract：:A valinomycin-based membrane phase for microelectrodes with relatively low electrical membrane resistances is described. Microelectrodes with tip diameters of about 1 micron exhibit resistances of about 10(10) omega. Extremely high K+ selectivities are obtained, e.g. a rejection of Na+ by a factor of 5000 and of acety...

journal_title：Neuroscience letters

authors： Ammann D,Chao PS,Simon W

更新日期：1987-02-24 00:00:00

abstract：:Early onset generalized dystonia is a dominantly inherited movement disorder caused by neuronal dysfunction without an apparent loss of neurons. The same single mutation (GAG deletion) causes most cases and results in loss of a glutamic acid (E) in the carboxy terminal region of torsinA (Delta302/303). To model the ne...

journal_title：Neuroscience letters

authors： Kock N,Allchorne AJ,Sena-Esteves M,Woolf CJ,Breakefield XO

更新日期：2006-03-13 00:00:00

abstract：:Neurons containing the peptide corticotropin-releasing factor (CRF) are thought to play a pivotal role in orchestrating autonomic and behavioral responses to stress. CRF afferents to the thalamus are almost entirely concentrated in the midline nuclei, especially in the paraventricular thalamic nucleus. In chloral hydr...

journal_title：Neuroscience letters

authors： Otake K,Nakamura Y

更新日期：1995-12-01 00:00:00

abstract：:Aging is associated with cognitive deterioration. A recent study showed two polymorphisms (rs505058 in LMNA and rs11622883 near a SERPINA13 gene), identified in a genome-wide association study of late-onset Alzheimer's disease, to be associated with cognitive function (Mini Mental State Examination) in a UK elderly po...

journal_title：Neuroscience letters

authors： Yeh HL,Hou SJ,Yen FC,Hong CJ,Liou YJ,Yang AC,Liu ME,Tsai SJ

更新日期：2011-10-17 00:00:00

abstract：:Estrogen was shown to promote neuronal survival against several neurotoxic insults including β-amyloid (Aβ). The proposed mechanism includes the activation of the mitogen activated protein kinase/extracellular signal-regulated kinase (Mapk/Erk), phosphatidylinositol 3-kinase/Akt pathways and the upregulation of antiap...

journal_title：Neuroscience letters

authors： Mateos L,Persson T,Katoozi S,Gil-Bea FJ,Cedazo-Minguez A

更新日期：2012-01-11 00:00:00

abstract：:The coupling of muscarinic agonist receptors to guanine nucleotide-binding (G) proteins was investigated in the frontal, temporal cortices and thalamus of control and Alzheimer brains by using carbachol in competition experiments with [3H]QNB. In the presence of GppNHp, the carbachol/[3H]QNB competition binding data s...

journal_title：Neuroscience letters

authors： Warpman U,Alafuzoff I,Nordberg A

更新日期：1993-02-05 00:00:00

abstract：:Methamphetamine (METH) has been a worldwide health threat for years. Recent studies have reported that circular RNA (circRNA) are highly abundant and dynamically expressed in brain. However, connections between circRNA and METH-induced neurotoxicity remains indefinite. In the present study, primary cortical neurons we...

journal_title：Neuroscience letters

authors： Li J,Shi Q,Wang Q,Tan X,Pang K,Liu X,Zhu S,Xi K,Zhang J,Gao Q,Hu Y,Sun J

更新日期：2019-05-14 00:00:00

abstract：:Recently, the gene called DAAO was reported to be associated with schizophrenia in the French Canadian populations. Here, we report a result obtained in the study of our large collection of 547 schizophrenia cases and 536 controls in the Chinese population. Six single-nucleotide polymorphisms (SNPs) were genotyped at ...

journal_title：Neuroscience letters

authors： Liu X,He G,Wang X,Chen Q,Qian X,Lin W,Li D,Gu N,Feng G,He L

更新日期：2004-10-21 00:00:00

abstract：:Using retrograde transport of Fluoro-Gold (FG) combined with immunofluorescence for phenylethanolamine-N-methyltransferase (PNMT), we have examined afferents to the nucleus locus coeruleus (LC) from the rostral ventrolateral medulla (nucleus paragigantocellularis; PGi) in rats sustaining lesions of the medullary adren...

journal_title：Neuroscience letters

authors： Astier B,Van Bockstaele EJ,Aston-Jones G,Pieribone VA

更新日期：1990-10-16 00:00:00

abstract：:The aim of the present study was to determine if pre-exposure to high doses of cocaine can subsequently alter the rewarding effects of this drug. Adult male mice received a pretreatment of physiological saline, or 12.5 or 25 mg/kg of cocaine (one injection a day for five days). After an interval of six days without in...

journal_title：Neuroscience letters

authors： Manzanedo C,García-Pardo MP,Rodríguez-Arias M,Miñarro J,Aguilar MA

更新日期：2012-05-10 00:00:00

abstract：:In this study the effect of exogenous oxytocin and of massage-like stroking on the withdrawal latency responses to heat and mechanical nociceptive stimulation were investigated in rats. A hot-plate test and the Randall-Selitto test were used to assess the withdrawal responses. Exogenous oxytocin (0.1-1 mg/kg) and stro...

journal_title：Neuroscience letters

authors： Agren G,Lundeberg T,Uvnäs-Moberg K,Sato A

更新日期：1995-02-24 00:00:00

abstract：:Transcranial magnetic stimulation is a non-invasive tool in clinical diagnostics and therapy for physiological and psychological diseases and has an increased application in experimental neurophysiology. Despite this, the mechanisms of magnetic stimulation of the central nervous system remain still unclear. We applied...

journal_title：Neuroscience letters

authors： Stock M,Kirchner B,Waibler D,Cowley DE,Pfaffl MW,Kuehn R

更新日期：2012-09-27 00:00:00

abstract：:Postmitotic neurons were generated from the human NT2 teratocarcinoma cell line in a novel cell aggregate differentiation procedure. The NT2 model neurons express punctate immunoreactivity for synapsin and for cell markers related to GABAergic and glutamatergic neurotransmission. Using the outside-out patch-clamp conf...

journal_title：Neuroscience letters

authors： Podrygajlo G,Song Y,Schlesinger F,Krampfl K,Bicker G

更新日期：2010-01-14 00:00:00

abstract：:Exposure of rat hippocampal neurons to the peptide amyloid beta (A beta) (25-35) as well as A beta (1-40) peptides enhances phosphorylation of tau to a paired helical filament (PHF)-state through activation of tau protein kinase I (TPK I)/glycogen synthase kinase-3 beta (GSK-3 beta) [Busciglio, J., Lorenzo, A., Yeh, J...

journal_title：Neuroscience letters

authors： Takashima A,Noguchi K,Michel G,Mercken M,Hoshi M,Ishiguro K,Imahori K

更新日期：1996-01-12 00:00:00

abstract：:Recent studies have shown that the inhibition of histone deacetylases (HDACs) induces the differentiation of diverse cancer and stem cells, which suggests HDAC inhibitors may be good candidates for the induction of stem cell differentiation. In this study, we investigated the effects of a HDAC inhibitor, valproic acid...

journal_title：Neuroscience letters

authors： Jeong SG,Ohn T,Kim SH,Cho GW

更新日期：2013-10-25 00:00:00