Abstract:
:In recent years, several attempts have been made to identify biochemical and/or genetic markers which might have diagnostic and prognostic uses for Alzheimer's disease (AD). To look for possible new blood markers, a longitudinal study was carried out in our Central Nervous System Biomedical Research Center between October 1996 and July 1998. A total of 30 AD subjects were diagnosed as AD patients according to the DSM-IV and NINCDS-ADRDA criteria. Vascular dementia (VD, n= 17), mixed dementia (MXD, n = 18) and healthy age-matched control subjects (n = 15) have been included in the study. Serum samples have been analysed by SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis) and the resulting protein patterns have been compared. The objectives of this study were to examine the presence of peripheral markers among patients with AD, VD and MXD and to explore the relationship between serum markers and APOE genotype. The findings suggest that two proteins of 19 and 20kDa molecular weight, respectively, might be associated with disease progression in different types of dementia.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lombardi VR,Cacabelos Rdoi
10.1016/s0304-3940(98)00960-4keywords:
subject
Has Abstractpub_date
1999-01-22 00:00:00pages
61-4issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(98)00960-4journal_volume
260pub_type
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journal_title:Neuroscience letters
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pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00101-9
更新日期:1999-03-19 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2006-12-20 00:00:00
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pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2017-03-22 00:00:00
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journal_title:Neuroscience letters
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更新日期:2010-09-06 00:00:00
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章
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更新日期:1999-04-30 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90591-4
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90242-8
更新日期:1984-04-06 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2014-08-08 00:00:00
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pub_type: 杂志文章
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更新日期:2004-02-19 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2011-06-15 00:00:00
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更新日期:2017-08-10 00:00:00
abstract:AIMS:To test the hypothesis that uridine 5'-triphosphate (UTP) had a protective effect on cerebral ischemia reperfusion (IR) injury in rats. METHODS:Ischemia was induced by intraluminal suture of middle cerebral artery occlusion (MCAO). UTP solution was delivered through an indwelling tail venous catheter via microinf...
journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2009-11-06 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2010.06.089
更新日期:2010-09-20 00:00:00
abstract::Auditory evoked potentials (AEPs) were recorded during presentation of stimuli of 1000 Hz (standard) and 2000 Hz (deviant) in trains of 10 tone bursts (one deviant per train) in the wake and rapid eye movement (REM) sleep states. The constant inter-stimulus interval (ISI) was 600 ms and the trains were separated by 3 ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00798-2
更新日期:1997-11-14 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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