Abstract：
:Changes in von Frey hair perception, pricking pain, and vibration thresholds were examined in six healthy human adults, in the zone of secondary hyperalgesia, 45 min following the topical application of capsaicin at concentrations of 0.05 and 0.1 mg/ml. In two of these subjects, cutaneous blood flow was monitored at 10-min intervals, before, during and after capsaicin application, using laser Doppler perfusion imaging. Thresholds for all three parameters were significantly reduced after capsaicin treatment, in a dose-dependent manner. However, there was no visible skin flare, and no change in cutaneous blood flow at these doses of capsaicin. The effects on von Frey perception threshold and vibration threshold have not been demonstrated previously, and may be indicative of central changes, initiated by afferent fibres (presumably C fibres) that are not vasoactive.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Andrews K,Baranowski A,Kinnman Edoi
10.1016/s0304-3940(99)00248-7keywords:
subject
Has Abstractpub_date
1999-04-30 00:00:00pages
45-8issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00248-7journal_volume
266pub_type
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