Abstract:
:In order to clarify the participation of substance P in the expression of opiate withdrawal, we have investigated the effects induced by the new selective neurokinin-1 antagonist RP 67580 on naloxone-induced morphine withdrawal syndrome in rats. Intracerebroventricular administration of RP 67580 elicited a decrease in 7 of the 13 withdrawal signs evaluated. Mastication, salivation and signs related to the motor component of withdrawal (jumping, rearing and locomotor activity) were particularly reduced. One sign, wet dog shakes, was increased, but it was also enhanced by the inactive enantiomer RP 68651. Our results indicate that blockade of NK1 receptors induces a decrease in the expression of naloxone-precipitated morphine abstinence in rats, and support the participation of substance P in the opiate withdrawal response.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Maldonado R,Girdlestone D,Roques BPdoi
10.1016/0304-3940(93)90457-vsubject
Has Abstractpub_date
1993-06-25 00:00:00pages
135-40issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90457-Vjournal_volume
156pub_type
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