Abstract：
:Intestinal electric stimulation (IES) has been shown to produce an inhibitory effect on gastric motility and secretion. The possible central mechanism of this entero-gastric inhibitory effect induced by IES is unknown. The objective of this study was to evaluate the effects of various IES on the activity of neurons in nucleus tractus solitarii (NTS). We examined the extracellular neuronal activity in NTS of the medulla in pentobarbital anesthetized, paralyzed, ventilated male adult rats. The aortic depressor, superior laryngeal, and carotid sinus nerves were crushed or sectioned bilaterally to avoid neuronal responses in NTS to cardiovascular baroreceptors. After NTS neurons with gastric input were identified, responses of single neurons in NTS to IES were determined. IES with different parameters was performed via a pair of platinum electrodes sutured onto the serosal surface of the duodenum 2 cm below the pylorus. IES with different parameters activated 39--72% of the solitary tract nucleus neurons responsive to gastric distension. Moreover, we demonstrated that IES activated the neuronal activity in NTS, which was stimulation energy dependent. The modulatory effect of IES on the central neurons receiving vagal inputs may contribute to the neural mechanisms of IES therapy for the treatment of patients with obesity and gastrointestinal motility disorders.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sun Y,Qin C,Foreman RD,Chen JDdoi
10.1016/j.neulet.2005.05.008keywords:
subject
Has Abstractpub_date
2005-09-02 00:00:00pages
64-9issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(05)00553-7journal_volume
385pub_type
杂志文章abstract：:The convulsive agent pentylenetetrazol (PTZ) antagonized gamma-aminobutyric acid (GABA)-induced membrane currents on RNA-injected Xenopus oocytes with both extra- and intracellular applications. With extracellular administration PTZ enters the cell within a few minutes and reaches concentrations in the millimolar rang...
journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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pub_type： 临床试验,杂志文章,多中心研究
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.02.051
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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doi：10.1016/0304-3940(96)12446-0
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：
更新日期：1996-09-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.10.104
更新日期：2009-01-09 00:00:00
