Abstract:
:In anesthetized rats, injections of a 0.5 mM glutamate solution into the locus coeruleus (LC) reversibly increased the amplitude of the population spike evoked in CA1 by stimulation of the Schaffer-commissural fiber tract. This effect was absent in N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4)-treated, noradrenaline (NA)-depleted animals. The excitatory postsynaptic potential recorded in the stratum radiatum was unaffected following the glutamate injections. Systemic administration of the NA-uptake inhibitor desipramine also produced an increase in population spike amplitude. The findings demonstrate that activation of LC neurons increases pyramidal cell excitability in vivo.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Olpe HR,Laszlo J,Pozza MF,De Herdt P,Waldmeier PC,Jones RSdoi
10.1016/0304-3940(86)90112-6subject
Has Abstractpub_date
1986-03-28 00:00:00pages
11-6issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(86)90112-6journal_volume
65pub_type
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