Glutamate-induced activation of rat locus coeruleus increases CA1 pyramidal cell excitability.

Abstract:

:In anesthetized rats, injections of a 0.5 mM glutamate solution into the locus coeruleus (LC) reversibly increased the amplitude of the population spike evoked in CA1 by stimulation of the Schaffer-commissural fiber tract. This effect was absent in N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4)-treated, noradrenaline (NA)-depleted animals. The excitatory postsynaptic potential recorded in the stratum radiatum was unaffected following the glutamate injections. Systemic administration of the NA-uptake inhibitor desipramine also produced an increase in population spike amplitude. The findings demonstrate that activation of LC neurons increases pyramidal cell excitability in vivo.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Olpe HR,Laszlo J,Pozza MF,De Herdt P,Waldmeier PC,Jones RS

doi

10.1016/0304-3940(86)90112-6

subject

Has Abstract

pub_date

1986-03-28 00:00:00

pages

11-6

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(86)90112-6

journal_volume

65

pub_type

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