Abstract:
:Neuroblastoma cells differentiate in response to retinoic acid and cyclic AMP. We have examined the expression of retinoic acid receptors (RARs) in relation to neuroblastoma differentiation and show that short term exposure of SK N SH, SH SY 5Y AND GI LI N cells to physiological concentrations of retinoic acid results in induction of RAR-beta, particularly the lower transcript. Cyclic AMP has no effect on retinoic acid mediated induction and does not alter RAR expression patterns. These data are discussed in the light of evidence that retinoic acid and cyclic AMP act either on different control pathways or at different points within a common pathway.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lovat PE,Pearson AD,Malcolm A,Redfern CPdoi
10.1016/0304-3940(93)90572-3subject
Has Abstractpub_date
1993-11-12 00:00:00pages
109-13issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90572-3journal_volume
162pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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