Retinoic acid receptor expression during the in vitro differentiation of human neuroblastoma.

Abstract:

:Neuroblastoma cells differentiate in response to retinoic acid and cyclic AMP. We have examined the expression of retinoic acid receptors (RARs) in relation to neuroblastoma differentiation and show that short term exposure of SK N SH, SH SY 5Y AND GI LI N cells to physiological concentrations of retinoic acid results in induction of RAR-beta, particularly the lower transcript. Cyclic AMP has no effect on retinoic acid mediated induction and does not alter RAR expression patterns. These data are discussed in the light of evidence that retinoic acid and cyclic AMP act either on different control pathways or at different points within a common pathway.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Lovat PE,Pearson AD,Malcolm A,Redfern CP

doi

10.1016/0304-3940(93)90572-3

subject

Has Abstract

pub_date

1993-11-12 00:00:00

pages

109-13

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(93)90572-3

journal_volume

162

pub_type

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