Adrenergic and non-adrenergic neurons in the C1 and C3 areas project to locus coeruleus: a fluorescent double labeling study.

Abstract:

:Following iontophoretic injections of the retrograde tracer Fluoro-gold into the rat locus coeruleus (LC), retrogradely labeled neurons were seen predominantly in the area of C1 adrenergic neurons in the ventrolateral medulla (nucleus paragigantocellularis; PGi) and in the area of C3 adrenergic neurons in the dorsomedial medulla (nucleus prepositus hypoglossi; PrH). Subsequent immunofluorescence for phenylethanolamine-N-methyltransferase indicated that adrenergic and non-adrenergic LC projecting neurons in both areas are interdigitated, and that 21% of LC afferent neurons in the PGi are adrenergic while only 4% of LC afferent neurons in the area of PrH are adrenergic.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Pieribone VA,Aston-Jones G,Bohn MC

doi

10.1016/0304-3940(88)90582-4

subject

Has Abstract

pub_date

1988-03-10 00:00:00

pages

297-303

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(88)90582-4

journal_volume

85

pub_type

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