Genetic deletion of the norepinephrine transporter decreases vulnerability to seizures.

abstract：:Bone mesenchymal stem cells (BMSCs) are an attractive donor graft source because of the potential of self-renewal and multi-direction differentiation. However, it is a great challenge to induce BMSCs to specifically differentiate to dopamine (DA) neurons for the treatment of Parkinson's disease. Because the striatum i...

journal_title：Neuroscience letters

authors： Yang S,Gao Q,Bao L,Zhang J,Hu Y,Bing L,Sun J,Hao J,Chen C,Li S,Poon WS,Sun J,Gao Y

更新日期：2012-11-21 00:00:00

abstract：:Iontophoretically applied 2-azido photoaffinity analogues of adenosine 5'-triphosphate (ATP) and adenosine 5'-monophosphate (AMP) have been tested on rat cerebral cortical neurons. 2-Azido-AMP and 2-azido-ATP had a powerful depressant action on the spontaneous firing of cortical neurons. Both compounds were equipotent...

journal_title：Neuroscience letters

authors： Phillis JW

更新日期：1981-01-01 00:00:00

abstract：:A new method for on-line analysis of in vivo differential normal pulse voltammograms is reported. They are fitted by least squares to an expression describing the contribution of different electroactive species and the baseline. Its validity for resolving ascorbate (AA), dopamine (DA) and DOPAC signals is evidenced by...

journal_title：Neuroscience letters

authors： Gonzalez-Mora JL,Sanchez-Bruno JA,Mas M

更新日期：1988-03-21 00:00:00

abstract：:Parkinson's disease (PD) is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Adenosine is a neuromodulator that inhibit the release of dopamine via a disinhibitory mechanism. In this study, we investigated the neuroprotective effect of 8-cyclopentyl-1,3-dipropylxanthine and...

journal_title：Neuroscience letters

authors： Fathalla AM,Soliman AM,Moustafa AA

更新日期：2017-03-16 00:00:00

abstract：:The presence of neuromelanic pigment in neurons of the rat substantia nigra (SN) is a matter of controversy. The presence of neuromelanin in the SN of 15--24-month-old rats was investigated by electron microscopy (EM) and the findings compared to the morphology and distribution of neuromelanin in SN of dogs. In the ra...

journal_title：Neuroscience letters

authors： DeMattei M,Levi AC,Fariello RG

更新日期：1986-12-03 00:00:00

abstract：:Bax, a pro-apoptotic member of Bcl-2 family proteins, plays a central role in mitochondria-dependent apoptosis. Bax normally resides in the cytosol in a quiescent state. Bax-inhibiting peptide (BIP) is a membrane permeable peptide comprised of five amino acids designed from the Bax-binding domain of Ku70 [M. Sawada, P...

journal_title：Neuroscience letters

authors： Qin Q,Patil K,Sharma SC

更新日期：2004-11-30 00:00:00

abstract：:Heat shock protein 70 family was demonstrated to play a critical role in protein homeostasis, a process profoundly impaired in neurodegenerative disorders. Neurodegenerative diseases are characterized by the accumulation of different kind of proteins and the formation of insoluble aggregates which are toxic for neuron...

journal_title：Neuroscience letters

authors： Sirtori R,Riva C,Ferrarese C,Sala G

更新日期：2020-09-25 00:00:00

abstract：:To investigate injury-induced alterations of purinergic P2Y receptor-mediated calcium responses in glial (Müller) cells of the rabbit retina, neural retinae were experimentally detached from the pigment epithelium. The ATP-evoked calcium responses were recorded in the endfeet of glial cells at the vitread surface of r...

journal_title：Neuroscience letters

authors： Uckermann O,Uhlmann S,Weick M,Pannicke T,Francke M,Reichenbach A,Wiedemann P,Bringmann A

更新日期：2003-02-27 00:00:00

abstract：:Glutamate receptor interacting protein (GRIP) is a member of the PDZ domain-containing protein family that is localized in the postsynaptic density area. This protein has been reported to interact specifically with the C-termini of AMPA-selective glutamate receptor channel subunits, GluRalpha2 and GluRalpha3 through i...

journal_title：Neuroscience letters

authors： Yamazaki M,Fukaya M,Abe M,Ikeno K,Kakizaki T,Watanabe M,Sakimura K

更新日期：2001-05-18 00:00:00

abstract：:The functional connections between corticospinal neurones and motor units of the monkey's hand muscles were investigated by constructing cross-correlograms of activity recorded from pyramidal tract neurones and from single motor units in the contralateral thenar muscles during performance of a precision grip between t...

journal_title：Neuroscience letters

authors： Mantel GW,Lemon RN

更新日期：1987-06-01 00:00:00

abstract：:An in vitro assay was used to determine the effects of conditioning nerve lesions on the regeneration of adult rat retinal ganglion cell (RGC) axons from retinal explants. Following the conditioning lesion (CL) of unilateral optic nerve transection, maximal regrowth was seen from RGC explanted from ipsilateral retinae...

journal_title：Neuroscience letters

authors： Johnson AR,Gregson NA,Wigley CB,Berry M

更新日期：1989-02-13 00:00:00

abstract：INTRODUCTION:Several lines of evidence support an immunologic involvement in obsessive-compulsive disorder (OCD): the increased prevalence of OCD in patients with rheumatic fever (RF), and the aggregation of obsessive-compulsive spectrum disorders among relatives of RF probands. Tumor necrosis factor alpha is a proinfl...

journal_title：Neuroscience letters

authors： Hounie AG,Cappi C,Cordeiro Q,Sampaio AS,Moraes I,Rosário MC,Palácios SA,Goldberg AC,Vallada HP,Machado-Lima A,Nakano E,Kalil J,Pauls D,Pereira CA,Guilherme L,Miguel EC

更新日期：2008-09-12 00:00:00

abstract：:Changes in contingent negative variation (CNV), a brain-evoked potential related in arousal, as well as in serum triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), prolactin (PRL), cortisol and growth hormone (GH) levels were recorded in 12 male volunteers receiving either thyrotropin-releasing ...

journal_title：Neuroscience letters

authors： Strollo F,Amabile G,Fattapposta F,Strollo G,More M,Riondino G

更新日期：1988-11-11 00:00:00

abstract：:Phencyclidine (PCP) is known to be an inhibitor of serotonin (5-HT) uptake and to increase serotonergic activity. The development of tolerance to serotonergic stereotyped behaviors induced by repeated PCP treatment and changes of 5-HT transporters were examined. Backpedalling was significantly reduced in frequency fol...

journal_title：Neuroscience letters

authors： Hori T,Abe S,Baba A,Suzuki T,Shiraishi H

更新日期：2000-02-11 00:00:00

abstract：:The extracellular concentrations of the lipid peroxidation product malonaldehyde (MDA) and the antioxidants ascorbic and uric acid were measured in rat brain in vivo using microdialysis coupled to HPLC with ultra violet spectrophotometry. Treatment with kainic acid at pH 4.1 (50 nmol) caused a significant increase in ...

journal_title：Neuroscience letters

authors： Waterfall AH,Singh G,Fry JR,Marsden CA

更新日期：1995-11-10 00:00:00

abstract：:The localization of luteinizing hormone-releasing hormone (LH-RH) has been studied in the human brain with the indirect immunofluorescence technique. LH-RH positive perikarya are scattered from the septo-preoptic region up to the retromammillary area and give rise to two main tracts ending in the infundibulum and the ...

journal_title：Neuroscience letters

authors： Barry J

更新日期：1976-12-01 00:00:00

abstract：:Bipolar disorder (BD) is a debilitating mental disorder with complex clinical manifestations and low diagnostic accuracy. Depressive episodes are most common in the course of BD with high comorbidity and suicide rates, which present greater clinical challenges than mania and hypomania episodes. However, there are no o...

journal_title：Neuroscience letters

authors： Ren Y,Chen ZZ,Sun XL,Duan HJ,Tian JS,Wang JY,Yang H

更新日期：2021-01-18 00:00:00

abstract：:Amyloid beta (Aβ) is the main component of the amyloid plaques that accumulate in the brains of Alzheimer patients. Here, we reported the protective role of Formononetin (Form) against Aβ25-35-induced neurotoxicity in HT22 cells. We found that Form significantly increased the viability of HT22 cells but decreased the ...

journal_title：Neuroscience letters

authors： Chen L,Ou S,Zhou L,Tang H,Xu J,Guo K

更新日期：2017-02-03 00:00:00

abstract：:We used whole-head magnetoencephalography to investigate cortical activity during two oromotor activities foundational to speech production. 13 adults performed mouth opening and phoneme (/pa/) production tasks to a visual cue. Jaw movements were tracked with an ultrasound-emitting device. Trials were time-locked to b...

journal_title：Neuroscience letters

authors： Memarian N,Ferrari P,Macdonald MJ,Cheyne D,De Nil LF,Pang EW

更新日期：2012-10-03 00:00:00

abstract：:In the present study we investigate the inhibitory circuitries that regulate the neuronal activity in the lateral and basal nuclei, which are the main sensory input regions of the amygdala. Axon terminals immunoreactive for parvalbumin, a calcium-binding protein known to colocalize with GABA, were examined in these re...

journal_title：Neuroscience letters

authors： Sorvari H,Miettinen R,Soininen H,Pitkänen A

更新日期：1996-10-18 00:00:00

abstract：:The effects of bath-applied phorbol esters, protein kinase C (PKC) activators, and sphingosine, a PKC inhibitor, on membrane currents evoked by serotonin were studied in Xenopus oocytes injected with rat brain mRNA. The oscillatory Cl- current in response to bath-applied 50 nM serotonin was significantly depressed by ...

journal_title：Neuroscience letters

authors： Matsumoto M,Barnard EA

更新日期：1994-02-14 00:00:00

abstract：:Previous studies showed that adenosine receptors of the temporal and frontal cortices were not affected in Alzheimer's disease (AD). Here, we assessed the specific binding of [3H]cyclohexyladenosine to adenosine1 (A1) receptors in hippocampus from AD subjects and age-matched controls. By both particulate membrane and ...

journal_title：Neuroscience letters

authors： Kalaria RN,Sromek S,Wilcox BJ,Unnerstall JR

更新日期：1990-10-16 00:00:00

abstract：:The heptadecapeptide histogranin, synthesized by adrenal chromaffin cells, is implicated in the analgesia produced by transplanting chromaffin cells into the spinal cord, including block of hyperalgesia mediated by NMDA-subtype glutamate receptors. To examine the neurophysiological basis for this analgesia, we applied...

journal_title：Neuroscience letters

authors： Hentall ID,Hargraves WA,Sagen J

更新日期：2007-05-23 00:00:00

abstract：:Both preischemic hyperglycemia and reduction of manganese superoxide dismutase activity are known to enhance neuronal death induced by transient cerebral ischemia. Transcriptional factor hypoxia-inducible factor 1 (HIF-1) regulates multiple downstream genes that modulate cell metabolism, survival, death, angiogenesis,...

journal_title：Neuroscience letters

authors： Bullock JJ,Mehta SL,Lin Y,Lolla P,Li PA

更新日期：2009-06-05 00:00:00

abstract：:Several side activities have been attributed to butyrylcholinesterase (BChE), including aryl acylamidase (AAA) activity, which is an amidase-like activity with unknown physiological function splitting the artificial substrate o-nitroacetanilide. For avians, extensive developmental data have pointed to neurogenetic fun...

journal_title：Neuroscience letters

authors： Weitnauer E,Robitzki A,Layer PG

更新日期：1998-10-02 00:00:00

abstract：:This study examined the effects of exposure to low concentrations (0.1-100 nM) of bisphenol A (BPA) or nonylphenol (NP) on neuronal differentiation in pheochromocytoma PC12 cells. Pre-exposure to BPA for a week or a month, but not for a day, decreased neuronal differentiation in PC12 cells. Likewise, one week's pre-ex...

journal_title：Neuroscience letters

authors： Nishimura Y,Nagao T,Fukushima N

更新日期：2014-06-06 00:00:00

abstract：:Jet propulsion fuel-8 (JP-8) is the predominant fuel for military land vehicles and aircraft used in the US and NATO. Occupational exposure to jet fuel in military personnel has raised concern for the health risk associated with such exposure in the Department of Defense. Clinical studies of humans chronically exposed...

journal_title：Neuroscience letters

authors： Lin B,Ritchie GD,Rossi J 3rd,Pancrazio JJ

更新日期：2004-06-17 00:00:00

abstract：:Spontaneous Frequency Bursts (SFBs) are a newly discovered form of long-distance neural coordination. They have several distinctive properties, including near-simultaneity of occurrence (+/-25-50 ms) across distant brain regions and high within- and across-site coherence in multiple low and high frequency bands, presu...

journal_title：Neuroscience letters

authors： Robson J,Mehta N,Polcz JE,Hermer L

更新日期：2010-03-03 00:00:00

abstract：:Emotions are at the core of human cognition and behavior. Traditionally, emotions have been classified dichotomously as being either positive or negative. However, recent behavioral research (An et al., 2017) suggests that emotions contain both positivity and negativity. The current work investigated neural correlates...

journal_title：Neuroscience letters

authors： An S,Han X,Wu B,Shi Z,Marks M,Wang S,Wu X,Han S

更新日期：2018-09-25 00:00:00

abstract：:The distribution of Purkinje cells projecting to the descending vestibular nucleus was studied in lobule IX (uvula) of the cat by the retrograde wheat germ agglutinin-horseradish peroxidase method. In the transverse plane labeled Purkinje cells were seen diffusely within 1.0 mm from the midline and densely for 250-500...

journal_title：Neuroscience letters

authors： Matsushita M,Wang CL

更新日期：1986-05-23 00:00:00