Effects of an activator and an inhibitor of protein kinase C on serotonin receptors induced by rat brain mRNA in Xenopus oocytes.

Abstract:

:The effects of bath-applied phorbol esters, protein kinase C (PKC) activators, and sphingosine, a PKC inhibitor, on membrane currents evoked by serotonin were studied in Xenopus oocytes injected with rat brain mRNA. The oscillatory Cl- current in response to bath-applied 50 nM serotonin was significantly depressed by 200 nM phorbol dibutyrate and remarkably augmented by 100 microM sphingosine. Both drugs have little effect either on the nonspecific Cl- current response induced by aluminum fluoride or on the cationic current response induced by 1 mM kainate.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Matsumoto M,Barnard EA

doi

10.1016/0304-3940(94)91057-x

subject

Has Abstract

pub_date

1994-02-14 00:00:00

pages

183-6

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(94)91057-X

journal_volume

167

pub_type

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