Myelin oligodendrocyte glycoprotein is expressed in the peripheral nervous system of rodents and primates.

Abstract:

:The myelin oligodendrocyte glycoprotein (MOG) is a minor CNS myelin-specific protein that is an important candidate autoantigen in multiple sclerosis. We now report that MOG mRNA transcripts are present in the peripheral nervous system of rodents and primates at levels approximately ten-fold lower than in brain as demonstrated by real time PCR. A major source of this signal are Schwann cells which are also shown to express MOG protein within their cytoplasm in vitro by immunohistochemistry. Expression of MOG by Schwann cells associated with tissue innervation may account for the widespread distribution of low levels of MOG mRNA transcripts, and potentially may provide a source of antigen that can influence the composition and function of the MOG-specific immune repertoire.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Pagany M,Jagodic M,Schubart A,Pham-Dinh D,Bachelin C,Baron van Evercooren A,Lachapelle F,Olsson T,Linington C

doi

10.1016/s0304-3940(03)00899-1

keywords:

subject

Has Abstract

pub_date

2003-10-30 00:00:00

pages

165-8

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394003008991

journal_volume

350

pub_type

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