Abstract:
:The myelin oligodendrocyte glycoprotein (MOG) is a minor CNS myelin-specific protein that is an important candidate autoantigen in multiple sclerosis. We now report that MOG mRNA transcripts are present in the peripheral nervous system of rodents and primates at levels approximately ten-fold lower than in brain as demonstrated by real time PCR. A major source of this signal are Schwann cells which are also shown to express MOG protein within their cytoplasm in vitro by immunohistochemistry. Expression of MOG by Schwann cells associated with tissue innervation may account for the widespread distribution of low levels of MOG mRNA transcripts, and potentially may provide a source of antigen that can influence the composition and function of the MOG-specific immune repertoire.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Pagany M,Jagodic M,Schubart A,Pham-Dinh D,Bachelin C,Baron van Evercooren A,Lachapelle F,Olsson T,Linington Cdoi
10.1016/s0304-3940(03)00899-1keywords:
subject
Has Abstractpub_date
2003-10-30 00:00:00pages
165-8issue
3eissn
0304-3940issn
1872-7972pii
S0304394003008991journal_volume
350pub_type
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