Abstract：
:Previous observations suggest a contribution of two APOE promoter polymorphisms (-219 G/T and -491 A/T) in dementia. From two independent populations of elderly (mean age of 84 and 85 years old, respectively), we observed that subjects bearing the -219T allele were at increased risk of dementia (OR = 1.9 (95% CI, 1.3-2.8), P = 0.0003) or AD (OR = 2.0 (95% CI, 1.2-3.4), P < 0.008). Conversely, the -491 A/T variant was not associated with this risk of dementia in the elderly, as previously described. Haplotype estimations including the two promoter and the coding APOE polymorphisms indicated that the -491A/-219T/4 haplotype was at risk for the development of dementia (OR = 3.5 (95% CI, 2.5-5.0), P < 0.0001), whereas the -491A/-219G/4 haplotype was not (OR = 1.1 (95% CI, 0.6-2.1)). Similar results were observed when restricted to Alzheimer's disease. In conclusion, these data indicate that the -219 G/T polymorphism is a genetic determinant of dementia in the elderly, independently of the 4 allele.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lambert JC,Berr C,Cottel D,Amouyel P,Helbecque Ndoi
10.1016/j.neulet.2004.04.063keywords:
subject
Has Abstractpub_date
2004-07-22 00:00:00pages
116-9issue
2eissn
0304-3940issn
1872-7972pii
S030439400400518Xjournal_volume
365pub_type
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journal_title：Neuroscience letters
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doi：10.1016/0304-3940(89)90546-6
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90696-5
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更新日期：2005-09-02 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.04.037
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2007-10-22 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章,评审
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更新日期：2011-06-27 00:00:00
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pub_type： 杂志文章
doi：10.1016/0304-3940(79)96121-4
更新日期：1979-12-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(96)13231-6
更新日期：1996-12-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2003.11.007
更新日期：2004-03-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(86)90058-3
更新日期：1986-01-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.09.018
更新日期：2012-10-24 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(79)90042-9
更新日期：1979-07-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90205-y
更新日期：1993-05-14 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(80)90285-2
更新日期：1980-10-02 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01452-x
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.03.020
更新日期：2006-06-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 临床试验,杂志文章
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journal_title：Neuroscience letters
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更新日期：1995-08-11 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.09.079
更新日期：2005-01-20 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1977-05-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1995-08-04 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90525-1
更新日期：1984-06-29 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.11.065
更新日期：2007-02-21 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.07.011
更新日期：2013-09-27 00:00:00
