Abstract:
:Previous studies have shown that the midbrain periaqueductal gray (PAG) projects to the ventrolateral medulla (VLM). Here, we studied PAG projections to the area of A1/C1 neurons in the VLM in the rat using phaseolus vulgaris leucoagglutinin (PHA-L) anterograde tracing combined with immunocytochemistry for tyrosine hydroxylase (TH) or phenylethanolamine N-methyl transferase (PNMT). Following PAG injections, PHA-L labeled fibers and terminals were intermingled among TH-immunoreactive (TH-ir) neurons in the VLM. High-power light microscopic examination revealed that some of the PHA-L labeled varicose fibers and boutons were in close contiguity with TH-ir elements. Such apparent appositions appeared more frequently on TH-ir elements in the A1 area than on TH-ir or PNMT-ir neurons in the C1 area. These results indicate that some PAG inputs to the VLM may directly innervate A1/C1 neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Chen S,Aston-Jones Gdoi
10.1016/0304-3940(94)11788-ksubject
Has Abstractpub_date
1995-08-04 00:00:00pages
140-4issue
2eissn
0304-3940issn
1872-7972pii
030439409411788Kjournal_volume
195pub_type
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