Anatomical evidence for inputs to ventrolateral medullary catecholaminergic neurons from the midbrain periaqueductal gray of the rat.

Abstract:

:Previous studies have shown that the midbrain periaqueductal gray (PAG) projects to the ventrolateral medulla (VLM). Here, we studied PAG projections to the area of A1/C1 neurons in the VLM in the rat using phaseolus vulgaris leucoagglutinin (PHA-L) anterograde tracing combined with immunocytochemistry for tyrosine hydroxylase (TH) or phenylethanolamine N-methyl transferase (PNMT). Following PAG injections, PHA-L labeled fibers and terminals were intermingled among TH-immunoreactive (TH-ir) neurons in the VLM. High-power light microscopic examination revealed that some of the PHA-L labeled varicose fibers and boutons were in close contiguity with TH-ir elements. Such apparent appositions appeared more frequently on TH-ir elements in the A1 area than on TH-ir or PNMT-ir neurons in the C1 area. These results indicate that some PAG inputs to the VLM may directly innervate A1/C1 neurons.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Chen S,Aston-Jones G

doi

10.1016/0304-3940(94)11788-k

subject

Has Abstract

pub_date

1995-08-04 00:00:00

pages

140-4

issue

2

eissn

0304-3940

issn

1872-7972

pii

030439409411788K

journal_volume

195

pub_type

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