Abstract:
:Distributions of one sensory and 13 motor axons to intrafusal fibers in a human spindle from the biceps brachii muscle were reconstructed from serial, 1 micron thick transverse sections. The primary afferent was distributed predominantly to nuclear bag fibers. Motor innervation in the human spindle was characterized by the presence of shared innervation among different types of intrafusal fiber, long unmyelinated preterminal segments of axon, and numerous short motor endings on both bag1 and bag2 fibers. These neuroanatomical features differ grossly from those in the cat tenuissimus spindles and may reflect a major functional difference.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kucera Jdoi
10.1016/0304-3940(86)90058-3subject
Has Abstractpub_date
1986-01-16 00:00:00pages
180-4issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(86)90058-3journal_volume
63pub_type
杂志文章abstract::The representation of time, space and numbers are strictly linked in the primate's cognitive system. Here we show that merely looking at number symbols biases a temporal judgment on their duration depending upon the number's magnitude. In a first experiment, a group of healthy subjects was submitted to a time estimati...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.04.051
更新日期:2008-06-27 00:00:00
abstract::We and others have previously reported that neurons expressing neuronal nitric oxide synthase (nNOS) do not co-express GTP cyclohydrolase I, the enzyme that synthesize its cofactor tetrahydrobiopterin (BH4). BH4 is released from catecholaminergic cells and nNOS-expressing cells are located close to BH4-producing catec...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2003.08.032
更新日期:2003-12-04 00:00:00
abstract:OBJECTIVES:To determine clinical characteristics and frequency of leucine-rich repeat kinase 2 gene (LRRK2) mutations in a cohort of patients with Parkinson's disease (PD) from Argentina. BACKGROUND:Variation in the LRRK2 gene represents the most common genetic determinant of PD, only few data are available from Latin...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.01.011
更新日期:2013-03-14 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90019-p
更新日期:1991-04-29 00:00:00
abstract::In this study we examined the presence of dopamine D1 receptors in monkey amniotic epithelial cells (MAEC) using RT-PCR and radioligand binding experiments. We found that MAEC express D1 receptor mRNA that is having 99% homology with human dopamine D1 receptors. Saturation binding studies using [3H]SCH-23390 showed a ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00016-6
更新日期:1999-02-26 00:00:00
abstract::The presence of neuromelanic pigment in neurons of the rat substantia nigra (SN) is a matter of controversy. The presence of neuromelanin in the SN of 15--24-month-old rats was investigated by electron microscopy (EM) and the findings compared to the morphology and distribution of neuromelanin in SN of dogs. In the ra...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90614-2
更新日期:1986-12-03 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.07.049
更新日期:2005-12-16 00:00:00
abstract::To determine the relationship between cholinergic modulation within the rat medial prefrontal cortex (mPFC) and the progress of lever-press extinction, we conducted an experiment in which muscarinic and nicotinic acetylcholine (ACh) receptor antagonists were microinjected into the mPFC. The muscarinic antagonist injec...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2003.07.012
更新日期:2003-11-13 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12676-8
更新日期:1996-05-31 00:00:00
abstract::The present study was designed to address the role of macrophages in Mn-induced neurotoxicity and to test the hypothesis that minocycline, a tetracycline derivative, attenuates the biochemical and morphological sequelae of Mn. Mn was unilaterally microinjected into rat nigra followed by systemic minocycline or saline ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.10.066
更新日期:2012-01-06 00:00:00
abstract::The development of supersensitivity to dopamine by striatal neurons is widely considered to be a response to interruption of dopaminergic synaptic function. However, it is not clear whether pre-existing dopaminergic innervation is in fact necessary for supersensitivity to develop. In this study, rat foetal striatal ce...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(96)12445-9
更新日期:1996-03-15 00:00:00
abstract::Striatal neurons containing acetylcholine and somatostatin were examined using a pharmacohistochemical procedure for acetylcholinesterase and NADPH-diaphorase histochemistry respectively. The use of these two histochemical procedures allowed both cholinergic and somatostatin cells to be visualized simultaneously in si...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(83)90536-0
更新日期:1983-02-21 00:00:00
abstract::Dinucleotide repeat polymorphism has been observed in the promoter of the alpha-synuclein (alpha-SYN)/NAC precursor protein (NACP) gene. Alpha-SYN/NACP allele 3 (described by Xia et al. (Ann. Neurol., 40 (1996) 207), equivalent to allele 1 described by Krüger et al. (Ann. Neurol. 45 (1999) 611) is reported to be signi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)01557-9
更新日期:2001-03-09 00:00:00
abstract::Temperature effects on ocular serotonin N-acetyltransferase (NAT) kinetics characteristics from Rana perezi have been studied with respect to tryptamine and serotonin as substrates. Monoamine oxidase (MAO) activity does not interfere in NAT assay at acceptoramine concentrations used in NAT kinetics characterization fr...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90667-a
更新日期:1993-05-28 00:00:00
abstract::Patients with schizophrenia are especially impaired in the detection of spatial location if the briefly presented target stimulus is followed by a mask in a close temporal proximity (target location backward masking (BM) paradigm). It has been suggested that this phenomenon is related to the impairment of low spatial ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01473-7
更新日期:2000-10-20 00:00:00
abstract::Current diagnosis of Major depressive disorder (MDD) depends on its clinical symptoms, not on the results of any laboratory examinations. Establishing biological markers for diagnosis of MDD is one of the most important problems to be solved in psychiatry practice. MDD patients (n=8) and a healthy control group (n=8) ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.06.039
更新日期:2016-08-26 00:00:00
abstract::The longest central nervous system (CNS) specific isoform of the major myelin-associated inhibitor of neurite growth, Nogo-A, has previously been shown to be expressed largely in oligodendrocytes. Using an antibody raised against a recombinant fusion protein comprising amino acids 223-399 of Nogo-A, we show in this re...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)00528-1
更新日期:2002-08-16 00:00:00
abstract::Little is known about the metabolic process of tau and tau-derived substances. Alz-50- and tau 2-immunoreactivities in intracellular granules of neurons were observed in regions surrounding infarcted foci in the human cerebral cortex. Ultrastructurally, these granules in the fresh infarcted region exhibited primary ly...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01009-0
更新日期:2000-04-28 00:00:00
abstract::The objective of the study was to investigate the presence and distribution of nerve cell bodies and small ganglia in the stroma of human submandibular gland. A retrospective immunohistochemical study in 13 human submandibular glands, fixed in neutral buffered formalin and embedded in paraffin wax, was undertaken. Six...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2010.03.045
更新日期:2010-05-07 00:00:00
abstract::Orexins (OXs) stimulate sympathetic nerve activity to increase arterial pressure (AP) and heart rate (HR). We have previously reported that the OX(1)-receptor antagonist SB-334867 reversed the sympathomimetic actions of orexin A (OXA). In the present study we have investigated the role(s) of the orexinergic system in ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.12.015
更新日期:2008-02-20 00:00:00
abstract::Our previous results demonstrated improved cognition in adolescent rats housed in environmental enrichment (EE) that underwent neonatal hypoxia-ischemia (HI). The aim of this study was to investigate the effects of early EE on neurobehavioral development and brain damage in rats submitted to neonatal HI. Wistar rats w...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.02.015
更新日期:2016-03-23 00:00:00
abstract::Malnutrition affects a large number of children worldwide. Inadequate nutrition during pre- and postnatal period may alter brain development resulting in biochemical, physiological and anatomical changes which in turn could cause behavioral abnormalities. The impairment of the central nervous system following protein ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.07.052
更新日期:2006-10-09 00:00:00
abstract::In order to search for compounds mimicking the neurotrophic activities, a series of substances possessing the guanidine group of isaxonine (2-isopropylamino-pyrimidine), were synthesized and tested for their ability to induce neurite outgrowth in cultures of explants of rat dorsal root ganglia. It is reported that sev...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90482-z
更新日期:1993-04-02 00:00:00
abstract::Substance P (SP) plays an important role in sensitization of spinal cord neurons. In this study, we investigated SP-induced calcium activities in cultured rat spinal cord neurons with confocal laser scanning microscopy. Our results showed that SP increased [Ca(2+)](i) by calcium entry rather than release from intracel...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01135-6
更新日期:2000-06-16 00:00:00
abstract::We recently established adrenal medullary cell line tsAM5D, which was immortalized by use of a temperature-sensitive mutant of the oncogene simian virus 40 large T-antigen. In the present study, when co-treated with glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF), tsAM5D cells...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.04.002
更新日期:2008-06-13 00:00:00
abstract::After systemic administration of the dopamine agonist apomorphine (APO) in common toads Bufo bufo spinosus, the excitatory receptive fields of retinal R2 and R3 ganglion cells doubled their size and the response activities of these neurons to moving visual stimuli were generally increased. Comparable investigations of...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90155-4
更新日期:1994-05-23 00:00:00
abstract::In this review, we summarize the recent development of positron emission tomography (PET) radioligands for γ-aminobutyric acid A (GABAA) receptors and their potential to measure changes in endogenous GABA levels and highlight the clinical and translational applications of GABA-sensitive PET radioligands. We review the...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2018.08.010
更新日期:2019-01-19 00:00:00
abstract::We have investigated the effect of capsaicin pretreatment (50 mg kg(-1) s.c.) on substance P, preprotachykinin (PPT) mRNA, and nerve growth factor (NGF), plus its high-affinity receptor, trkA, in adult rats with adjuvant arthritis. Twenty one days after induction of adjuvant arthritis, sciatic nerve levels of substanc...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00458-8
更新日期:1997-07-11 00:00:00
abstract::Long-term repeated application of morphine induces plasticity changes in sensitive neurons, which represents the neurobiological basis of morphine addiction. Caveolin-1 (Cav-1) is an important scaffolding protein that plays a key role in the regulation of neurostructural plasticity. However, in-depth studies focused o...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.11.033
更新日期:2018-02-05 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) has been proposed as a key regulator and mediator of long-term synaptic modifications related to learning and memory maintenance. Our previous studies show that application of high-frequency stimulation (HFS) sufficient to elicit LTP at the dentate gyrus (DG)-CA3 pathway produc...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.08.069
更新日期:2008-11-07 00:00:00