Effect of capsaicin on substance P and nerve growth factor in adjuvant arthritic rats.

abstract：:We examined the specific rat 125I-alpha-rat atrial natriuretic peptide(1-28)[ANF-(99-126)] (125I-rANP) binding sites in the cerebral capillaries from the cerebral cortex of male adult Wistar rats. The binding of 125I-rANP at 37 degrees C was saturable and of high affinity with a Kd of approximately 100 pM and Bmax of ...

journal_title：Neuroscience letters

authors： Niwa M,Ibaragi M,Tsutsumi K,Kurihara M,Himeno A,Mori K,Ozaki M

更新日期：1988-08-15 00:00:00

abstract：:The neuroprotective activity of riluzole has been studied on N-methyl-D-aspartate (NMDA)- or veratridine-induced toxicity in immature rat hippocampal slices. Neurodegeneration was assessed by the measurement of LDH release and histology. Veratridine-induced LDH release can be inhibited by 100 microM riluzole (-90% and...

journal_title：Neuroscience letters

authors： Malgouris C,Daniel M,Doble A

更新日期：1994-08-15 00:00:00

abstract：:'Clipsin' and other peptide bond hydrolase activities that appear to be integral membrane proteins, including two implicated in the formation of the histological hallmarks of Alzheimer's disease, were assayed in the frontal and parietal cortex from a large (n = 45) series of postmortem human brains. Tissues were extra...

journal_title：Neuroscience letters

authors： Stratmann GC,Webster MT,Francis PT,Procter AW,Bowen DM

更新日期：1992-08-31 00:00:00

abstract：:The effects of caloric restriction (CR) on cognition and behavior in developing mice were investigated in this study. Male and female Kunmin mice were fed a standard rodent diet ad libitum (Control); 80% of control (20% CR) or 65% of control (35% CR) for 6 months. Body weight gain was significant reduced in CR mice re...

journal_title：Neuroscience letters

authors： Wu A,Sun X,Liu Y

更新日期：2003-03-20 00:00:00

abstract：:Sertindole has been marketed and offered daily clinical practice only for 9 months in our country, so no data has been its QTc prolongation potential. In the present study, we performed a clinical trial to investigate the effects of sertindole on QTc in patients with schizophrenia. The study comprised 21 patients with...

journal_title：Neuroscience letters

authors： Atmaca M,Yavuzkir M,Mermi O,Topuz M,Kanmaz E,Tezcan E

更新日期：2008-09-05 00:00:00

abstract：:We investigated glutamate-induced neuron response in the ventral nerve cord of the earthworm (Eisenia foetida) using a voltage-sensitive dye-imaging technique. Isolated earthworm ganglia were stained by fluorescence voltage-sensitive dye, RH414, and voltage image was acquired by a conventional charge-coupled device (C...

journal_title：Neuroscience letters

authors： Oka K,Ogawa H,Fujita S

更新日期：1994-09-26 00:00:00

abstract：:The 5-HT(1A) receptor agonist 8-OH-DPAT (0.5mg/kg) enhances behavioral recovery when administered 15min after experimental traumatic brain injury (TBI). To determine if benefits are still attainable at clinically relevant times, treatment was delayed 1 and 2h post-TBI and motor/cognitive performance was compared to ea...

journal_title：Neuroscience letters

authors： Cheng JP,Aslam HA,Hoffman AN,Zafonte RD,Kline AE

更新日期：2007-04-12 00:00:00

abstract：:Focal ischemia was induced in the fronto-parietal region of rat brain, by injection of Rose Bengal, followed by light activation. Focal ischemia was accompanied by formation of PGD(2) peaking 60-90 min post irradiation and declining thereafter. Increased Cycloxygenase-2 (COX-2) expression was also observed. Control is...

journal_title：Neuroscience letters

authors： Govoni S,Masoero E,Favalli L,Rozza A,Scelsi R,Viappiani S,Buccellati C,Sala A,Folco G

更新日期：2001-05-04 00:00:00

abstract：:Three variations of the in vitro neonatal rat spinal cord preparation were used to investigate motor responses to stimulation of the ventrolateral funiculus (VLF). In a partially hemisected spinal cord preparation, stimuli elicited frequency-dependent activity in lumbar ventral roots that outlasted the stimulus train ...

journal_title：Neuroscience letters

authors： Magnuson DS,Schramm MJ,MacLean JN

更新日期：1995-06-09 00:00:00

abstract：:We have studied the electrophysiological properties of hippocampal neurons grown on surfaces of organic thin films formed on glass or silicon substrates and on microelectronic device surfaces in culture. Hippocampal neurons were dissociated from embryonic rats and plated on substrates chemically modified with laminin ...

journal_title：Neuroscience letters

authors： Offenhäusser A,Sprössler C,Matsuzawa M,Knoll W

更新日期：1997-02-14 00:00:00

abstract：:Previous studies using short-interval paired-pulse TMS have provided valuable insights into physiology of human motor cortex. Depending on the interstimulus interval (ISI) between the two pulses intra-cortical facilitation (ICF) or intra-cortical inhibition (ICI) can be observed. Similar patterns of inhibition and fac...

journal_title：Neuroscience letters

authors： Sparing R,Dambeck N,Stock K,Meister IG,Huetter D,Boroojerdi B

更新日期：2005-07-15 00:00:00

abstract：:trk receptors are downregulated in both dorsal root ganglion (DRG) and spinal motoneurons of aged rats with behavioral sensorimotor deficits. Here we provide evidence, using reverse transcription-polymerase chain reaction (RT-PCR), of decreased levels of neurotrophin (nerve growth factor, NGF; brain-derived neurotroph...

journal_title：Neuroscience letters

authors： Ming Y,Bergman E,Edström E,Ulfhake B

更新日期：1999-10-08 00:00:00

abstract：:Interleukin-18 (IL-18) is a pro-inflammatory cytokine and an important mediator of peripheral inflammation and host immune response. IL-18 functions through its binding with the IL-18 receptor (IL-18R), which consists of two chains, an IL-18-binding α chain (IL-18Rα) and a signaling β chain. IL-18 and IL-18R are expre...

journal_title：Neuroscience letters

authors： Kuwahara-Otani S,Maeda S,Kobayashi K,Minato Y,Tanaka K,Yamanishi K,Hata M,Li W,Hayakawa T,Noguchi K,Okamura H,Yagi H

更新日期：2017-05-22 00:00:00

abstract：:Molecular mechanisms regulating positions of oligodendrocyte precursor cells (OPCs) remain unclear in developing cerebral cortex. To explore the mechanisms, we investigated how Plexin-A4, receptor of Semaphorin in OPCs, is involved in the positioning. We found that Plexin-A4 knockout mice exhibited (1) an increased nu...

journal_title：Neuroscience letters

authors： Okada A,Tomooka Y

更新日期：2012-05-16 00:00:00

abstract：:We raised polyclonal antibodies against the C-terminal peptides of protein kinase C (PkC) subspecies alpha, beta 1, beta 2, gamma, delta, epsilon, and zeta and checked their specificity against brain extracts using Western immunoblot analysis. With equal amounts of protein applied to gels PkC subspecies beta 1, delta,...

journal_title：Neuroscience letters

authors： Gott AL,Mallon BS,Paton A,Groome N,Rumsby MG

更新日期：1994-04-25 00:00:00

abstract：:Epileptiform activity is a state often induced in vitro in order to study seizures and antiepileptic/anticonvulsant drugs. Traditional methods of evaluating drug effects have commonly relied upon measuring changes in the frequency and duration of such events. We have used a recently developed mathematical technique ba...

journal_title：Neuroscience letters

authors： Harrison PK,Tattersall JE,Clement RA

更新日期：2004-03-11 00:00:00

abstract：:In Creutzfeldt-Jakob disease (CJD), progressive neuronal cell death probably occurs as a result of a change in conformation of the physiological prion protein (PrP(C)). There is evidence of participation of the lymphatic system and in particular of lymphocytes in the intracorporeal transportation of the pathological p...

journal_title：Neuroscience letters

authors： Ratzka P,Döhlinger S,Cepek L,Steinacker P,Arlt S,Jacobi C,Schröter A,Wiltfang J,Prange H,Kretzschmar HA,Poser S,Otto M

更新日期：2003-05-29 00:00:00

abstract：:To clarify the possible role of in the in vivo toxic effects of 6-hydroxydopamine (6-OHDA), especially caspase activations, we examined its effects on striatal lipid peroxidation (LPO) and caspase activations in 6-OHDA-lesioned mice. Both dopamine (DA) levels and DA turnover were significantly changed by the 6-OHDA i....

journal_title：Neuroscience letters

authors： Tanaka K,Ogawa N,Asanuma M

更新日期：2006-12-20 00:00:00

abstract：:The role of the lateral hypothalamus (LHT) in the regulation of feeding behavior has long been established. The major contribution of LHT glucose-sensitive neurons, activated by low glucose concentration, is well accepted. Two peptidergic neuron populations, whose perikarya are exclusively located within this area, ha...

journal_title：Neuroscience letters

authors： Bahjaoui-Bouhaddi M,Fellmann D,Bugnon C

更新日期：1994-02-28 00:00:00

abstract：:The projections of neurons, in and around the A1 noradrenergic cell group of the caudal ventrolateral medulla (VLM), to nucleus of the solitary tract (NTS) were studied in the cat using the anterograde transport of Phaseolus vulgaris leucoagglutinin (PHA-L). PHA-L was micro-iontophoresed into the region of the A1 nora...

journal_title：Neuroscience letters

authors： Roder S,Ciriello J

更新日期：1992-01-06 00:00:00

abstract：:The presence of a novel member of serine proteinase inhibitor, B-43, was immunohistochemically indicated in both neurons and astrocytes in the parietal region of the bovine brain. B-43-like immunoreactivity was detected in pyramidal cells in the cortex and GFAP-positive astroglial cells in the white matter. The proces...

journal_title：Neuroscience letters

authors： Nishibori M,Ohtsuka A,Kawabata M,Nakaya N,Murakami T,Saeki K

更新日期：1995-11-17 00:00:00

abstract：:Presence of substance P-like immunoreactive neurons and nerve fibers is demonstrated in the trigeminal ganglion of newborn and adult human subjects by the indirect immunofluorescence technique. Two populations of neurons containing high and low densities of immunoreactive material, respectively, are identified. Morpho...

journal_title：Neuroscience letters

authors： Del Fiacco M,Quartu M,Floris A,Diaz G

更新日期：1990-03-02 00:00:00

abstract：:The pathogenic mechanism underlying Parkinson's disease (PD) and PD- Cognitive impairment (CI) remains elusive. Its potential link to the risk factors in Alzheimer's disease (AD) is unclear. In this study, we analyzed 16 CE-associated single nucleotide polymorphisms (SNPs) in twelve genes in a Chinese cohort of 450 PD...

journal_title：Neuroscience letters

authors： Fang L,Tang BS,Fan K,Wan CM,Yan XX,Guo JF

更新日期：2018-06-11 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a promising method for use in the clinical field, as it can induce modulation of cortical excitability. Generally, rTMS inhibits the motor cortex when delivered at less than 1 Hz. However, it has been indicated that a facilitative effect is induced by 1 Hz rTMS, d...

journal_title：Neuroscience letters

authors： Nojima K,Iramina K

更新日期：2018-01-18 00:00:00

abstract：:Serotonin transporter gene may play a critical role in a regulation of mood and other aspects of mental status. A large number of association studies have investigated a correlation between the polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR) and anxiety-related personality traits. The resul...

journal_title：Neuroscience letters

authors： Umekage T,Tochigi M,Marui T,Kato C,Hibino H,Otani T,Kohda K,Kato N,Sasaki T

更新日期：2003-01-30 00:00:00

abstract：:Direct exposure of rats to tobacco smoke induces antinociception. We presently investigated if this antinociception is mediated via nicotinic and/or mu-opioid receptors. Adult male rats were surgically implanted with Alzet osmotic minipumps that delivered either saline (control), the nicotinic antagonist mecamylamine,...

journal_title：Neuroscience letters

authors： Simons CT,Cuellar JM,Moore JA,Pinkerton KE,Uyeminami D,Carstens MI,Carstens E

更新日期：2005-12-02 00:00:00

abstract：:In human caudate and cortex membranes, [3H]serotonin ([3H]5-HT) labels 5-HT1A and 5-HT1C recognition sites which show nanomolar affinity for 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)-tetralin) and mesulergine respectively, whereas no 5-HT1B binding could be identified. However, the majority of the sites labelled by [3...

journal_title：Neuroscience letters

authors： Hoyer D,Waeber C,Pazos A,Probst A,Palacios JM

更新日期：1988-03-10 00:00:00

abstract：:The mesencephalic trigeminal nucleus contains cell bodies of primary somatic sensory neurons that innervate the head region. The neurons resemble dorsal root ganglion cells but a striking difference is the presence of synaptic boutons in the nucleus. The present report demonstrates with anterograde tracers, the existe...

journal_title：Neuroscience letters

authors： Buisseret-Delmas C,Pinganaud G,Compoint C,Buisseret P

更新日期：1997-07-04 00:00:00

abstract：:The melanocortin receptor type 2 (MC2R or adrenocorticotropic hormone, ACTH receptor) gene (MC2R) encodes a protein involved in regulation of adrenal cortisol secretion, important in the physiological response to stressors. A variant of MC2R, -179A>G, results in reduction of promoter activity and less adrenal action. ...

journal_title：Neuroscience letters

authors： Proudnikov D,Hamon S,Ott J,Kreek MJ

更新日期：2008-04-25 00:00:00

abstract：:The influence of chronic arthritic pain upon the levels of mRNA encoding prodynorphin (mRNADYN) in the spinal cord of rats was evaluated by use of the RNA blot technique. Rats were rendered arthritic by inoculation of the tail-base with a suspension of Mycobacterium butyricum. Three weeks post inoculation, levels of m...

journal_title：Neuroscience letters

authors： Höllt V,Haarmann I,Millan MJ,Herz A

更新日期：1987-01-02 00:00:00