Molecular basis of 6-hydroxydopamine-induced caspase activations due to increases in oxidative stress in the mouse striatum.

abstract：:Long-term potentiation (LTP) in the dentate gyrus was previously shown to be enhanced by nicotine, an effect dependent on both homomeric α7 and heteromeric α2β2 nicotinic acetylcholine receptors (nAChR). In our experiments, bath-applied nicotine produced no significant enhancement of LTP. The α7 nAChR silent agonist N...

journal_title：Neuroscience letters

authors： Papke RL,Peng C,Kumar A,Stokes C

更新日期：2018-06-11 00:00:00

abstract：:Although minocycline has been generally thought to have neuroprotective properties, the neuroprotective role of minocycline has not been investigated in the animal model of epilepsy. In this study, we investigated whether minocycline is neuroprotective against kainic acid (KA)-induced cell death through the caspase-de...

journal_title：Neuroscience letters

authors： Heo K,Cho YJ,Cho KJ,Kim HW,Kim HJ,Shin HY,Lee BI,Kim GW

更新日期：2006-05-08 00:00:00

abstract：:Using specific radioimmunoassays, melatonin was quantified in the aqueous humor and serum of male pigmented rabbits adapted to 12L:12D with lights on at 06.00 h. Melatonin concentrations in the aqueous humor at 08.00 and 16.00 h were similar (mean: 5.23 pg/ml) and significantly lower than those at 22.00 and 01.00 h (m...

journal_title：Neuroscience letters

authors： Yu HS,Yee RW,Howes KA,Reiter RJ

更新日期：1990-08-24 00:00:00

abstract：:Nitric oxide (NO) mediates cell-cell signalling in the brain and stimulates cyclic GMP (cGMP) production in target cells. We have used NADPH-diaphorase (reduced nicotinamide adenine dinucleotide phosphate-diaphorase) histochemistry to identify NO-producing neurones and cGMP immunohistochemistry to locate the targets o...

journal_title：Neuroscience letters

authors： Southam E,Morris R,Garthwaite J

更新日期：1992-03-30 00:00:00

abstract：:The analgesic effect of kappa partial agonist opioids (i.e. nalbuphine, pentazocine and butorphanol) is significantly greater in women. Recent evidence suggests that this sexual dimorphism may result from a naloxone-sensitive anti-analgesic effect that is activated along with, and summates with, the analgesic effect o...

journal_title：Neuroscience letters

authors： Gear RW,Gordon NC,Miaskowski C,Paul SM,Heller PH,Levine JD

更新日期：2003-11-06 00:00:00

abstract：:Incorporation of ubiquitin and ubiquitin-related proteins including p62 into neuronal intranuclear inclusions (NIIs) has been reported in a variety of neurodegenerative diseases. However, involvement of autophagy-specific proteins (NBR1 and LC3) in NIIs has not been mentioned. We immunohistochemically examined the bra...

journal_title：Neuroscience letters

authors： Mori F,Tanji K,Odagiri S,Toyoshima Y,Yoshida M,Kakita A,Takahashi H,Wakabayashi K

更新日期：2012-08-01 00:00:00

abstract：:Effective treatments to improve survivability following exposure to the nerve agent soman have been established and are currently available. Unfortunately, electrographic brain seizures, neuroinflammation and brain cell death are still a potential problem even with treatment. In the present study we have characterized...

journal_title：Neuroscience letters

authors： Williams AJ,Berti R,Yao C,Price RA,Velarde LC,Koplovitz I,Schultz SM,Tortella FC,Dave JR

更新日期：2003-10-09 00:00:00

abstract：:In situ whole cell voltage clamp recordings of presumed folliculo-stellate cells were made in the intermediate lobe of the clawed toad Xenopus laevis. Lucifer Yellow fillings revealed, in addition to the small, spherical melanotropes, a population of larger cells with many processes that were, to a limited extent, dye...

journal_title：Neuroscience letters

authors： Borst JG,Lodder JC,Roubos EW,Kits KS

更新日期：1996-05-03 00:00:00

abstract：:Ischemic preconditioning is considered to be the most robust endogenous neuroprotectant. However, the conventional ischemic preconditioning protocol is both invasive and impractical to apply. The aim of the present study was to evaluate whether preconditioning with +Gz centrifuge acceleration (head-to-foot inertial lo...

journal_title：Neuroscience letters

authors： Sang H,Li J,Liu J,Wang Z,Huo T,Sun J,Xiong L

更新日期：2008-11-07 00:00:00

abstract：:Apolipoprotein(a) [apo(a)] is a highly polymorphic glycoprotein which has been suggested to play a role in Alzheimer's disease (AD). Plasma lipoprotein(a) [Lp(a)] levels and the differential expression of apo(a) isoforms were analyzed in 73 sporadic AD patients compared with 73 age- and gender-matched healthy controls...

journal_title：Neuroscience letters

authors： Emanuele E,Peros E,Tomaino C,Feudatari E,Bernardi L,Binetti G,Maletta R,D'Angelo A,Montagna L,Bruni AC,Geroldi D

更新日期：2004-02-26 00:00:00

abstract：:Superfusion of the isolated spinal cord of neonatal rats (4-9 days postpartum) with physiological medium containing 2-chloroadenosine (2-CA) or anoxic medium (equilibrated with 95% N2-5% CO2) depressed the evoked monosynaptic reflex (MSR) recorded extracellularly from a ventral spinal root. The effectiveness of 2-CA o...

journal_title：Neuroscience letters

authors： Lloyd HG,Perkins A,Spence I

更新日期：1989-06-19 00:00:00

abstract：:The Heat Shock Factors (HSFs) have been historically identified as a family of transcription factors that are activated and work in a stress-responsive manner, after exposure to a large variety of stimuli. However, they are also critical in normal conditions, in a life long manner, in a number of physiological process...

journal_title：Neuroscience letters

authors： Duchateau A,de Thonel A,El Fatimy R,Dubreuil V,Mezger V

更新日期：2020-04-23 00:00:00

abstract：:The effects of classical fear conditioning in different regions of the limbic system were analysed using cytochrome oxidase (CO) histochemistry. Wistar rats were submitted to different conditions. Rats in the group Paired received tone-shock pairing, to elicit conditioned suppression of lever pressing (i.e., tone will...

journal_title：Neuroscience letters

authors： Conejo NM,López M,Cantora R,González-Pardo H,López L,Begega A,Vallejo G,Arias JL

更新日期：2005-01-10 00:00:00

abstract：:After hypoxic-ischemic insult iron deposited in the brain catalyzes formation of reactive oxygen species. Newborn rats, showing reduced physiological body temperature and their hyperthermic counterparts injected with deferoxamine (DF), a chelator of iron, are protected both against iron-mediated neurotoxicity and agai...

journal_title：Neuroscience letters

authors： Kletkiewicz H,Nowakowska A,Siejka A,Mila-Kierzenkowska C,Woźniak A,Caputa M,Rogalska J

更新日期：2016-08-15 00:00:00

abstract：:It has been proposed that the perception of a coherent image necessitates two processes, that is, an ensemble of neurons which synchronizes discharges of individual cells and stimulus-specific gamma-band (gamma) neuronal oscillations which may serve as carrier signals for a temporal code. We tested the hypothesis that...

journal_title：Neuroscience letters

authors： Shumikhina S,Molotchnikoff S

更新日期：1999-09-10 00:00:00

abstract：:The three tracers horseradish peroxidase (HRP), 4',6-diamidino-2-phenylindol-2HCl (DAPI) and Fast Blue (FB) differ in retrograde labeling of striato-nigral neurons. After a 24 h survival, injection of DAPI into the ventral tegmentum labeled numerous cells throughout the neostriatum, whereas an identical amount of HRP ...

journal_title：Neuroscience letters

authors： Frotscher M,Wagner A,Misgeld U

更新日期：1983-07-29 00:00:00

abstract：:Discrete brain structures were analysed for gamma-aminobutyric acid (GABA) and vasopressin content in normo- and hypotensive rats treated with the glutamic acid decarboxylase inhibitor, 3-mercaptopropionic acid (MPA) and the GABAA agonist muscimol. In the normotensive group treated with MPA only, the concentration of ...

journal_title：Neuroscience letters

authors： Magnusson A,Höglund U,Sjöquist M

更新日期：1989-07-03 00:00:00

abstract：:We examined the effect of intraventricular injection of nerve growth factor (NGF) on the choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) mRNA expression in the septa of neonatal rats. Rat pups were injected with 2.5 S NGF or cytochrome-c (control) on postnatal days (PN) 4 and 18, and s...

journal_title：Neuroscience letters

authors： Tian X,Sun X,Suszkiw JB

更新日期：1996-05-10 00:00:00

abstract：:The effects of administration of 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphorylcholine (O-DH-PC), a kind of lecithin, and of glycerophosphorylcholine (GPC) on sleep were investigated in male F344 rats. Intracerebroventricular administration of O-DH-PC at a dose of 10 micrograms/rat induced significant increase in ...

journal_title：Neuroscience letters

authors： Hashimoto M,Gong XW,Izaki Y,Iriki M,Hibino H

更新日期：1993-08-06 00:00:00

abstract：:IgGs from two LEMS patients applied to human neuroblastoma IMR32 cells reduced the density of low- (LVA; T) and high-threshold (HVA; L and N) Ba2+ currents by different percentages: 36% (LVA) and 56% (HVA) for one and 48% and 45% for the other. A pharmacological assay of IgGs action based on the block of L-type channe...

journal_title：Neuroscience letters

authors： Grassi C,Magnelli V,Carabelli V,Sher E,Carbone E

更新日期：1994-11-07 00:00:00

abstract：:A partially purified toxin obtained from the coral reef crab, Lophozozymus pictor was found to be a potent inhibitor of Na+-dependent [14C]-GABA uptake by rat brain synaptosomes. Inhibition was potentiated in the presence of external K+. The I50 value for the toxin was found to be in the region of 10 microgram/ml at a...

journal_title：Neuroscience letters

authors： Tan CH,Abkowitz SJ

更新日期：1979-10-01 00:00:00

abstract：:Prostaglandins (PGs) were measured in perfusate from the lumbar intrathecal (IT) space of pentobarbital anaesthetized rats. The level of PGE2, but not of PGF2 alpha or 6-keto PGF1 alpha, was increased by immersion of a hindpaw in water at a noxious temperature (50 degrees C). No increase in PGE2 was produced by non-no...

journal_title：Neuroscience letters

authors： Coderre TJ,Gonzales R,Goldyne ME,West J,Levine JD

更新日期：1990-07-31 00:00:00

abstract：:It is debated whether non-affected relatives of patients with affective disorders share a specific brain structure endophenotype. Aim of this work is to explore the medial temporal morphology in affected and non-affected members of a family with mood disorders. Hippocampi and amygdalae were manually traced from the 3D...

journal_title：Neuroscience letters

authors： Boccardi M,Almici M,Bresciani L,Caroli A,Bonetti M,Monchieri S,Gennarelli M,Frisoni GB

更新日期：2010-01-04 00:00:00

abstract：:Erythropoietin (EPO) and its specific receptor (EPOR) have been proposed to act as an endogenous system protecting against neuronal injury and neurodegeneration. We measured EPO in cerebrospinal fluid (CSF) of patients with neurodegenerative diseases, and tested for a correlation with an established biomarker of neuro...

journal_title：Neuroscience letters

authors： Brettschneider J,Widl K,Ehrenreich H,Riepe M,Tumani H

更新日期：2006-09-01 00:00:00

abstract：:Studies have demonstrated the changes of the physiological characteristics of nucleus accumbens (NAc) neurons with the postnatal development of rats. In the present study, spontaneous excitatory postsynaptic currents (sEPSCs) were recorded in the slices of NAc shell (NAcS) of adult and juvenile rats. Our results demon...

journal_title：Neuroscience letters

authors： Liu XD,Liu Z,Kong QY,Zhang JJ,Wang Y,Yu LC

更新日期：2011-06-01 00:00:00

abstract：:To examine postural stability of the head, slow, undetectable rotations of small amplitude were imposed about a vertical axis while human subjects maintained a stationary body. Six normal subjects were used. The rotations were imposed through an elastic linkage, and lasted 4 s. The amplitude of head rotation was small...

journal_title：Neuroscience letters

authors： Chan R,Rogers DK,McCloskey DI

更新日期：1996-08-23 00:00:00

abstract：:An intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1), that is located at a well established Alzheimer's disease (AD) locus on chromosome 9q22, was recently associated with increased risk for late-onset AD. We analyzed this polymorphism in two independent AD samples consisting of pa...

journal_title：Neuroscience letters

authors： Brouwers N,Sleegers K,Engelborghs S,Bogaerts V,van Duijn CM,De Deyn PP,Van Broeckhoven C,Dermaut B

更新日期：2006-01-09 00:00:00

abstract：:Alzheimer's disease has become one of the most impacting disorders since world population is rapidly aging. MicroRNA-125b plays a crucial role in many cellular processes and pathologies, but, to date, its role in Alzheimer's disease is controversial. In this study, we demonstrated, for the first time, that the down re...

journal_title：Neuroscience letters

authors： Micheli F,Palermo R,Talora C,Ferretti E,Vacca A,Napolitano M

更新日期：2016-08-26 00:00:00

abstract：:Parkinson's disease (PD) is defined as a chronic neurodegenerative disorder which is diagnosed mostly by its clinical manifestations. Reactive oxygen species (ROS) are considered as key modulators in the development of PD. Despite the intensive investigations, antioxidant-dependent molecular mechanisms of initiation a...

journal_title：Neuroscience letters

authors： Hemmati-Dinarvand M,Saedi S,Valilo M,Kalantary-Charvadeh A,Alizadeh Sani M,Kargar R,Safari H,Samadi N

更新日期：2019-09-14 00:00:00

abstract：:Febrile seizures (FSs) are the most common type of convulsions in childhood and complex FSs represent an increased risk for development of temporal lobe epilepsy. The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia ind...

journal_title：Neuroscience letters

authors： Dai YJ,Wu DC,Feng B,Hou WW,Xu CL,Ohtsu H,Chen Z,Hu WW

更新日期：2015-02-19 00:00:00