Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases.

abstract：:Many recent studies have revealed the consistency of anticipatory postural adjustments preceding single leg movements, such as stepping, in standing humans. These adjustments appear to involve an active lateral transfer of weight to the stance leg. The present study demonstrates that these anticipatory adjustments oft...

journal_title：Neuroscience letters

authors： McIlroy WE,Maki BE

更新日期：1993-12-24 00:00:00

abstract：:Our previous study has shown that both electroacupuncture (EA) and vagus nerve stimulation (VNS) can inhibit cortical epileptiform activities induced by pentylenetetrazole (PTZ). The current study compared the effects of EA and VNS on thalamic neuronal responses to PTZ-induced epileptiform activities. Under general an...

journal_title：Neuroscience letters

authors： Zhang JL,Zhang SP,Zhang HQ

更新日期：2008-08-22 00:00:00

abstract：:Samples collected from rabbit neocortical surface during a tetanic stimulation of the neocortex induced neurite growth in PC-12 cells in culture and synaptic long-term potentiation (LTP) in guinea pig hippocampal slices. If these samples were preheated and cooled, or if they were collected in the absence of a tetanic ...

journal_title：Neuroscience letters

authors： Sastry BR,Chirwa SS,May PB,Maretić H

更新日期：1988-08-15 00:00:00

abstract：:A neurogenic contribution to joint inflammation has been demonstrated in rat adjuvant arthritis, however as inflammatory mechanisms vary between species it is unclear whether these observations can be applied more generally. The aim of this study was to assess the neurogenic contribution to cellular infiltration and o...

journal_title：Neuroscience letters

authors： Hood VC,Cruwys SC,Urban L,Kidd BL

更新日期：2001-02-23 00:00:00

abstract：:Depression associated with diabetes has been described as a highly debilitating comorbidity. Due to its complex and multifactorial mechanisms, the treatment of depression associated with diabetes represents a clinical challenge. Cannabidiol (CBD), the non-psychotomimetic compound derived from Cannabis sativa, has been...

journal_title：Neuroscience letters

authors： de Morais H,Chaves YC,Waltrick APF,Jesus CHA,Genaro K,Crippa JA,da Cunha JM,Zanoveli JM

更新日期：2018-08-24 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the presence of beta-amyloid (Abeta) protein deposits in the brain and increased Abeta (1-42) peptide production is thought to be one of the early events in the pathogenesis of AD that leads to progressive neurodegenerative processes and dementia. Using cDNA subtraction and...

journal_title：Neuroscience letters

authors： Heese K,Nagai Y,Sawada T

更新日期：2000-07-07 00:00:00

abstract：:Surface molecules play important roles in a wide range of cellular functions, yet little has been reported regarding the expression of such markers by neural stem cells. Here, multipotent human neural progenitor cells (hNPCs) were expanded as a monolayer in the presence of fibroblast/epidermal growth factor, harvested...

journal_title：Neuroscience letters

authors： Klassen H,Schwartz MR,Bailey AH,Young MJ

更新日期：2001-10-26 00:00:00

abstract：:The association between (GT)n dinucleotide repeats in monoamine oxidase gene loci, monoamine oxidase A (MAOA) and B (MAOB), and Parkinson's disease (PD), Alzheimer's disease (AD), and Lewy body variant (LBV) of AD were determined. MAOA-GT polymorphisms were significantly associated with pure AD and LBV. MAOA-GT allele...

journal_title：Neuroscience letters

authors： Takehashi M,Tanaka S,Masliah E,Ueda K

更新日期：2002-07-19 00:00:00

abstract：:We investigated a possible involvement of the prion protein in ventilatory control in four groups of mice, those deficient for the prion protein (PrP(c)), those overexpressing the prion protein, and two groups of genetically and age-matched controls. Ventilatory patterns of unrestrained mice were measured in a whole-b...

journal_title：Neuroscience letters

authors： Boudinot E,Tremblay P,Champagnat J,Foutz AS

更新日期：2002-04-26 00:00:00

abstract：:We examined the association between endogenous opioid β-endorphin, cancer progression and pain in a transgenic mouse model of breast cancer, with a rat C3(1) simian virus 40 large tumor antigen fusion gene (C3TAg). C3TAg mice develop ductal epithelial atypia at 8 weeks, progression to intra-epithelial neoplasia at 12 ...

journal_title：Neuroscience letters

authors： Argueta DA,Aich A,Lei J,Kiven S,Nguyen A,Wang Y,Gu J,Zhao W,Gupta K

更新日期：2021-01-23 00:00:00

abstract：:Previous work from our laboratory has shown that naïve Wistar Audiogenic Rats (WARs), a genetic model of reflex epilepsy in which seizures are induced by high-intensity sound stimulation (120 dB SPL), are seizure-prone to a variety of pro-convulsive stimuli (e.g., transauricular electroshock, pentylenetetrazole and pi...

journal_title：Neuroscience letters

authors： Magalhães LH,Garcia-Cairasco N,Massensini AR,Doretto MC,Moraes MF

更新日期：2004-10-07 00:00:00

abstract：:Recent evidence indicates that the N-methyl-D-aspartate (NMDA) receptor-channel complex contains a glycine subunit whose activation may be necessary for channel operation. It has been previously shown that stimulation of the NMDA receptor leads to an increase in intracellular ionic Ca2+ [( Ca2+]i); therefore, we exami...

journal_title：Neuroscience letters

authors： Oliver MW,Shacklock JA,Kessler M,Lynch G,Baimbridge KG

更新日期：1990-07-03 00:00:00

abstract：:Bone mesenchymal stem cells (BMSCs) are an attractive donor graft source because of the potential of self-renewal and multi-direction differentiation. However, it is a great challenge to induce BMSCs to specifically differentiate to dopamine (DA) neurons for the treatment of Parkinson's disease. Because the striatum i...

journal_title：Neuroscience letters

authors： Yang S,Gao Q,Bao L,Zhang J,Hu Y,Bing L,Sun J,Hao J,Chen C,Li S,Poon WS,Sun J,Gao Y

更新日期：2012-11-21 00:00:00

abstract：:The ability of increases in extracellular potassium ([K+]o) and/or decreases in extracellular calcium ([Ca2+]o) to induce epileptiform activity in hippocampal slices was studied by systematically varying [K+]o and [Ca2+]o. Slices prepared from kindled rats, both 1 week and 1 month after the last kindled seizure, showe...

journal_title：Neuroscience letters

authors： Stringer JL,Lothman EW

更新日期：1988-06-17 00:00:00

abstract：:Repeated stress triggers a wide range of adaptive changes in the central nervous system including the elevation of serotonin (5-HT) metabolism and an increased susceptibility to affective disorders. To begin to examine whether these changes are mediated by alterations in gene expression for tryptophan hydroxylase (TPH...

journal_title：Neuroscience letters

authors： Chamas F,Serova L,Sabban EL

更新日期：1999-06-04 00:00:00

abstract：:The present study was designed to determine whether a state of neuropathic pain induced by sciatic nerve ligation could alter phosphorylated-mu-opioid receptor-like immunoreactivity in the superficial dorsal horn of the mouse spinal cord. Mice with sciatic nerve ligation exhibited a significant suppression of the morp...

journal_title：Neuroscience letters

authors： Narita M,Kuzumaki N,Suzuki M,Narita M,Oe K,Yamazaki M,Yajima Y,Suzuki T

更新日期：2004-01-09 00:00:00

abstract：:Chemical irritation of the urinary bladder with formalin in the rat induced c-fos protein-like immunoreactivity in more than 80% of substance P receptor-like immunoreactive (SPR-LI) neurons of the dorsal commissural nucleus, sacral parasympathetic nucleus and lamina I in the 6th lumbar and 1st sacral cord segments. Th...

journal_title：Neuroscience letters

authors： Lü Y,Jin SX,Xu TL,Qin BZ,Li JS,Ding YQ,Shigemoto R,Mizuno N

更新日期：1995-09-29 00:00:00

abstract：:At postnatal day (PN)1, there are sex differences in gonadal receptor expression in the rat substantia nigra pars reticulata (SNR). Male pups have lower levels of androgen receptor (AR) and estrogen receptor (ER)beta immunoreactivity (IR) compared to female pups, while ERalpha IR is equally expressed in the two sexes....

journal_title：Neuroscience letters

authors： Ravizza T,Velísková J,Moshé SL

更新日期：2003-02-20 00:00:00

abstract：:PC12 rat pheochromocytoma cells undergo programmed cell death or apoptosis with DNA fragmentation when deprived of serum. Here, we isolated a subclone of PC12, PC12FrR, that was resistant to DNA fragmentation in a serum-free condition. PC12FrR grew slightly faster, and had cells that were slightly larger than parental...

journal_title：Neuroscience letters

authors： Sawada M,Kondo N,Marunouchi T

更新日期：1995-05-26 00:00:00

abstract：:Immunohistochemical fluorescent double labeling revealed the coexistence of galanin and substance P in nerve fibers in the mouse nasal mucosa. At the base of and in the epithelium, all galanin fibers also contained substance P, but around the blood vessels and glands, most of them did not. Since substance P fibers in ...

journal_title：Neuroscience letters

authors： Matsuda H,Tsukuda M,Kadota T,Kusunoki T,Kishida R

更新日期：1994-05-23 00:00:00

abstract：:The ubiquitin carboxy-terminal hydrolase L1gene (UCH-L1) has been implicated in the aetiology of Parkinson's disease (PD). A rare Ile93Met mutation in UCH-L1 in a German PD sib-pair has been reported. Recently, a S18Y (C54A) polymorphism in exon 3 of UCH-L1 was found to be under-represented in PD patients compared to ...

journal_title：Neuroscience letters

authors： Mellick GD,Silburn PA

更新日期：2000-10-27 00:00:00

abstract：:The regional cerebral blood flow (rCBF) was measured with positron emission tomography in eight normal volunteers with the purpose of measuring rCBF changes related to the comprehension of an unfamiliar spoken languages. When attempting to comprehend the meaning of words, the left hemisphere showed dominant increases ...

journal_title：Neuroscience letters

authors： Kawashima R,Itoh M,Hatazawa J,Miyazawa H,Yamada K,Matsuzawa T,Fukuda H

更新日期：1993-10-14 00:00:00

abstract：:Oxidative damage induced-mitochondrial dysfunction and apoptosis has been widely studied in spinal cord injury (SCI). Lycopene, a polyunsaturated hydrocarbon, has the highest antioxidant capacity compared to the other carotenoids. However, the role of lycopene in SCI is unknown. In the present study, we evaluated the ...

journal_title：Neuroscience letters

authors： Hu W,Wang H,Liu Z,Liu Y,Wang R,Luo X,Huang Y

更新日期：2017-03-06 00:00:00

abstract：:The activities of RNA-dependent DNA polymerase and DNA-dependent DNA polymerase were measured in hippocampus of fast and slow learning Wistar rats. The RNA-dependent DNA polymerase activity in the hippocampus of fast learning rats exceeds two-fold that in the slow learning ones, while the rates of the DNA-dependent DN...

journal_title：Neuroscience letters

authors： Salganik RI,Parvez H,Tomsons VP,Shumskaya IA

更新日期：1983-04-29 00:00:00

abstract：:MicroRNA-146a (miRNA-146a) is an inducible, 22 nucleotide, small RNA over-expressed in Alzheimer's disease (AD) brain. Up-regulated miRNA-146a targets several inflammation-related and membrane-associated messenger RNAs (mRNAs), including those encoding complement factor-H (CFH) and the interleukin-1 receptor associate...

journal_title：Neuroscience letters

authors： Li YY,Cui JG,Dua P,Pogue AI,Bhattacharjee S,Lukiw WJ

更新日期：2011-07-20 00:00:00

abstract：:Postmitotic neurons were generated from the human NT2 teratocarcinoma cell line in a novel cell aggregate differentiation procedure. The NT2 model neurons express punctate immunoreactivity for synapsin and for cell markers related to GABAergic and glutamatergic neurotransmission. Using the outside-out patch-clamp conf...

journal_title：Neuroscience letters

authors： Podrygajlo G,Song Y,Schlesinger F,Krampfl K,Bicker G

更新日期：2010-01-14 00:00:00

abstract：:People with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (Abeta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and Abeta1-40 and Abeta1-42 concentrations were found and nor were Abeta1-40 and Abeta1-42 levels...

journal_title：Neuroscience letters

authors： Jones EL,Hanney M,Francis PT,Ballard CG

更新日期：2009-02-20 00:00:00

abstract：:The neurotransmitter gamma-aminobuteric acid (GABA) is believed to have a controlling action on spinal locomotor networks. In spasticity, spinal locomotor networks are thought to play a role. A well known drug in the treatment of spasticity is the GABA(B) agonist Baclofen. We report an inhibitory effect of Baclofen on...

journal_title：Neuroscience letters

authors： de Louw AJ,de Vente J,Steinbusch HP,Steinbusch HW,Troost J,Vles JS

更新日期：2002-03-15 00:00:00

abstract：:Histone modifications, such as lysine methylation, acetylation and ubiquitination, are epigenetic tags that shape the chromatin landscape and regulate transcription required for synaptic plasticity and memory. Here, we show that transcription-promoting histone H3 trimethylated at lysine 4 (H3K4me3), histone H3 acetyla...

journal_title：Neuroscience letters

authors： Bach SV,Tacon PR,Morgan JW,Hegde AN

更新日期：2015-03-30 00:00:00

abstract：:Large-conductance calcium-activated potassium channels (BK channels) have been suggested to play a substantial role in synaptic transmission in the spinal cord dorsal horn. In the present experiments, we attempted to clarify the physiological significance of BK channels in the modulation of synaptic transmission in th...

journal_title：Neuroscience letters

authors： Furukawa N,Takasusuki T,Fukushima T,Hori Y

更新日期：2008-10-17 00:00:00