Abstract:
:Alzheimer's disease has become one of the most impacting disorders since world population is rapidly aging. MicroRNA-125b plays a crucial role in many cellular processes and pathologies, but, to date, its role in Alzheimer's disease is controversial. In this study, we demonstrated, for the first time, that the down regulation of miR-125b is a key event for the neurotoxic effect of Aβ treatment in cortical neurons. Moreover, we found that 17β-estradiol treatment protects neurons from the Aβ-peptide induced neurotoxicity by increasing miR-125b expression that, in turn, decreased the expression, both at gene and protein levels, of the pro-apoptopic proteins Bak1 and p53. Overall, our data reveal miR-125b as a novel neuro-protector miRNA in Alzheimer's disease.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Micheli F,Palermo R,Talora C,Ferretti E,Vacca A,Napolitano Mdoi
10.1016/j.neulet.2016.05.049subject
Has Abstractpub_date
2016-08-26 00:00:00pages
234-240eissn
0304-3940issn
1872-7972pii
S0304-3940(16)30377-9journal_volume
629pub_type
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