A glycine antagonist reduces ischemia-induced CA1 cell loss in vivo.

Abstract:

:Excessive activation of the N-methyl-D-aspartate (NMDA) receptor-channel complex has been implicated as one of the mechanisms by which ischemia-induced neuronal damage is mediated. Elevated glycine levels during ischemia may contribute to damage mediated by the NMDA receptor as glycine binding potentiates NMDA responses, and may be necessary for channel opening. We investigated the protective effects of 7-chlorokynurenic acid--a competitive antagonist at the glycine binding site associated with the NMDA receptor--against hippocampal CA1 cell loss induced by transient forebrain ischemia in rats. Intraventricular administration of the drug immediately before the onset of ischemia significantly attenuated neuronal loss compared to vehicle-treated animals.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Wood ER,Bussey TJ,Phillips AG

doi

10.1016/0304-3940(92)90191-9

keywords:

subject

Has Abstract

pub_date

1992-09-28 00:00:00

pages

10-4

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(92)90191-9

journal_volume

145

pub_type

杂志文章
  • Potato not Pope: human brain potentials to gender expectation and agreement in Spanish spoken sentences.

    abstract::Event-related potentials were used to examine the role of grammatical gender in auditory sentence comprehension. Native Spanish speakers listened to sentence pairs in which a drawing depicting a noun was either congruent or incongruent with sentence meaning, and agreed or disagreed in gender with the immediately prece...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(03)00599-8

    authors: Wicha NY,Bates EA,Moreno EM,Kutas M

    更新日期:2003-08-07 00:00:00

  • Conduction velocity of motor nerve and cervical sympathetic and vagus nerve in streptozotocin diabetic rats.

    abstract::We investigated the conduction velocity of motor and autonomic nerves, motor nerve to foot interosseous muscle and cervical vagus and sympathetic nerve, in streptozotocin diabetic rats (1-3 months duration of diabetes) and compared it with that of age-matched controls. In diabetic rats, the motor nerve conduction velo...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90489-v

    authors: Yamazaki Y,Karakida T,Homma S

    更新日期:1990-05-18 00:00:00

  • Effects of acetylcholine antagonist injection into the prefrontal cortex on the progress of lever-press extinction in rats.

    abstract::To determine the relationship between cholinergic modulation within the rat medial prefrontal cortex (mPFC) and the progress of lever-press extinction, we conducted an experiment in which muscarinic and nicotinic acetylcholine (ACh) receptor antagonists were microinjected into the mPFC. The muscarinic antagonist injec...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2003.07.012

    authors: Maruki K,Izaki Y,Akema T,Nomura M

    更新日期:2003-11-13 00:00:00

  • Modification of the monoaminergic neurotransmitters in frontal cortex and hippocampus by dietary trans alpha-linolenic acid in piglets.

    abstract::The effect of partial isomerization of dietary alpha-linolenic acid on the monoaminergic neurotransmitters in piglets was studied. After feeding the animals for 14 days with diets containing or not trans alpha-linolenic acid, neurotransmitters related to the monoaminergic function were quantified in the frontal cortex...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)00879-0

    authors: Acar N,Chardigny JM,Berdeaux O,Almanza S,Sébédio JL

    更新日期:2002-10-18 00:00:00

  • Neuromagnetic somatosensory homunculus: a non-invasive approach in humans.

    abstract::The somatosensory homunculus has been identified during stimulation of median (at wrist and elbow), femoral, tibial and pudendal nerves of the left hemibody via the neuromagnetic imaging technique. The somatic representations of different body districts have been localized in the somatosensory cortex, by means of an e...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90647-c

    authors: Narici L,Modena I,Opsomer RJ,Pizzella V,Romani GL,Torrioli G,Traversa R,Rossini PM

    更新日期:1991-01-02 00:00:00

  • Colocalization of GABA and glycine immunoreactivities in a subset of retinal neurons in tiger salamander.

    abstract::Alternate serial 1 micron Durcupan resin sections of tiger salamander retina were stained with antisera against GABA and glycine using postembed immunocytochemical techniques. Although the vast majority of neurons were labeled by either GABA or glycine antiserum, a small percentage of presumed amacrine cells in the in...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90628-3

    authors: Yazulla S,Yang CY

    更新日期:1988-12-19 00:00:00

  • Dihydropyridines modulate K+-evoked amino acid and adenosine release from cerebellar neuronal cultures.

    abstract::Partial depolarization of primary cerebellar neuronal cultures with K+ evoked the release of aspartate, glutamate, adenosine, serine, taurine, gamma-aminobutyric acid (GABA), alanine and proline. The dihydropyridine calcium channel agonist, BAY K 8644, significantly augmented the K+-induced release of adenosine, aspar...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90314-5

    authors: Philibert RA,Dutton GR

    更新日期:1989-07-17 00:00:00

  • The neural mechanism of biomechanical constraints in the hand laterality judgment task: A near-infrared spectroscopy study.

    abstract::The mental rotation (MR) task is defined as a discrimination task between mirror-reversed images involving discrepancy in angular orientation. Various studies have shown that the MR task likely causes mental imagery, that is, visual and/or motor imagery, depending on stimulus types. When figures of rotated hands are p...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.05.069

    authors: Meng S,Oi M,Sekiyama K,Saito H

    更新日期:2016-08-03 00:00:00

  • Towards plasma-like collisionless trajectories in the brain.

    abstract::Plasma studies depict collisionless, collective movements of charged particles. In touch with these concepts, originally developed by the far-flung branch of high energy physics, here we evaluate the role of collective behaviors and long-range functional couplingsof charged particlesin brain dynamics. We build a novel...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2017.10.016

    authors: Tozzi A,Peters JF,Déli E

    更新日期:2018-01-01 00:00:00

  • Immunohistochemical analysis of developmental stage of external granular layer neurons which undergo apoptosis in postnatal rat cerebellum.

    abstract::Some granule neurons naturally undergo apoptosis in the external granular layer (EGL) of the postnatally developing rat cerebellum. We analyzed the developmental stage-specificity of this apoptosis using double staining by in situ nick end labeling and immunohistochemistry against three proteins expressed at specific ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(98)00032-9

    authors: Tanaka M,Marunouchi T

    更新日期:1998-02-13 00:00:00

  • Course corrections of deflected retinal axons on the tectum of the chick embryo.

    abstract::Recently developed neuroanatomical staining methods utilizing transportable markers have made it possible to visualize individual, growing retinotectal axons in the chick embryo. In the present work, we used such methods to examine the behavior of mechanically deflected axons on the tectum. The deflection of axons was...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90613-0

    authors: Thanos S,Bonhoeffer F

    更新日期:1986-12-03 00:00:00

  • GRP immunoreactivity shows a day-night difference in the suprachiasmatic nuclear soma and efferent fibers: comparison to VIP immunoreactivity.

    abstract::Day-night variations of gastrin releasing peptide (GRP) in the neuronal somal area of the SCN and the nearby region on the anterior hypothalamic area (AHA) where GRP fibers project, were examined by semiquantitative immunocytochemistry, and compared with those of vasoactive intestinal peptide (VIP). Both in the SCN an...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90585-1

    authors: Okamura H,Ibata Y

    更新日期:1994-11-07 00:00:00

  • Evidence of a direct projection of the vomeronasal organ to the medial preoptic nucleus and hypothalamus.

    abstract::In rodents the vomeronasal system plays an important role in modulating the hypothalamic control of gonadotropin secretion. It is accepted that the anatomical pathways by which the vomeronasal organ influences the neuroendocrine aspects of the reproductive behavior involves a polysynaptic system, including the accesso...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90225-a

    authors: Larriva-Sahd J,Rondán A,Orozco-Estévez H,Sánchez-Robles MR

    更新日期:1993-11-26 00:00:00

  • GWAS analysis of suicide attempt in schizophrenia: Main genetic effect and interaction with early life trauma.

    abstract:OBJECTIVES:Suicide attempt in schizophrenia is an important clinical issue. We performed a genome-wide association study to identify genetic markers, which increase the risk for suicide attempt in schizophrenia. METHODS:Suicide attempt lifetime was assessed in 121 schizophrenia patients and defined by the means of the...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.04.043

    authors: Bani-Fatemi A,Graff A,Zai C,Strauss J,De Luca V

    更新日期:2016-05-27 00:00:00

  • Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction.

    abstract::The melanocortin receptor type 2 (MC2R or adrenocorticotropic hormone, ACTH receptor) gene (MC2R) encodes a protein involved in regulation of adrenal cortisol secretion, important in the physiological response to stressors. A variant of MC2R, -179A>G, results in reduction of promoter activity and less adrenal action. ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.02.042

    authors: Proudnikov D,Hamon S,Ott J,Kreek MJ

    更新日期:2008-04-25 00:00:00

  • Hemicholinium-3-resistant choline uptake system linked to acetylcholine synthesis in the rat hippocampus.

    abstract::Extracellular choline-dependency of acetylcholine (ACh) synthesis was examined in rat hippocampal slices. In the presence of hemicholinium-3 (HC-3, 5 microM), extracellular choline-dependent ACh synthesis appeared to consist of two different components. The first component (saturated at up to 50 microM choline) was de...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90039-6

    authors: Suzuki T,Kashima Y,Kawashima K

    更新日期:1989-10-23 00:00:00

  • Study of breakthrough cancer pain in an animal model induced by endothelin-1.

    abstract::Cancer patients with bone metastases often suffer breakthrough pain. However, little progress has been made in the treatment of breakthrough pain and its associated mechanism(s) in the patient with cancer due to lacking of resembling and predictive animal models. We previously have demonstrated that endothelin-1 plays...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.01.053

    authors: Tang Y,Peng H,Liao Q,Gan L,Zhang R,Huang L,Ding Z,Yang H,Yan X,Gu Y,Zang X,Huang D,Cao S

    更新日期:2016-03-23 00:00:00

  • Targets for preventing epilepsy following cortical injury.

    abstract::Prophylaxis of posttraumatic epilepsy will require a detailed knowledge of the epileptogenic pathophysiological processes that follow brain injury. Results from studies of experimental models and human epilepsy highlight alterations in GABAergic interneurons and formation of excessive new excitatory synaptic connectiv...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.neulet.2011.02.042

    authors: Li H,McDonald W,Parada I,Faria L,Graber K,Takahashi DK,Ma Y,Prince D

    更新日期:2011-06-27 00:00:00

  • Chronic stroke and aging: the impact of acoustic stimulus intensity on fractionated reaction time.

    abstract::In control samples, intense acoustic "go" stimuli accelerate the central and peripheral motor processes that compose simple reaction time movements. The goal of the current study was to determine whether movements that are initiated to intense acoustic cues facilitate simple reaction times in (1) adults with chronic s...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.01.041

    authors: Coombes SA,Janelle CM,Cauraugh JH

    更新日期:2009-03-13 00:00:00

  • Altered levels of brain neurotransmitter from new born rabbits with intrauterine restriction.

    abstract::Fetal intrauterine growth restriction generates chronic hypoxia due to placental insufficiency. Despite the hemodynamic process of blood flow, redistributions are taking place in key organs such as the fetal brain during intrauterine growth restriction, in order to maintain oxygen and nutrients supply. The risk of sho...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.09.051

    authors: Hernández-Andrade E,Cortés-Camberos AJ,Díaz NF,Flores-Herrera H,García-López G,González-Jiménez M,Santamaría A,Molina-Hernández A

    更新日期:2015-01-01 00:00:00

  • Striatal dopamine receptors in Alzheimer-type dementia.

    abstract::Dopamine D1 and D2 receptors were studied in putamen of post-mortem brains from controls and patients with Alzheimer-type dementia (ATD). A significant reduction in dopamine D2 receptors was observed in ATD, whereas dopamine D1 receptors were unchanged. Neurochemical markers of striatal acetylcholine and GABA-containi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90341-0

    authors: Cross AJ,Crow TJ,Ferrier IN,Johnson JA,Markakis D

    更新日期:1984-11-23 00:00:00

  • Trophic effect of various neuropeptides on the cultured ventral spinal cord of rat embryo.

    abstract::We studied the trophic effects of various neuropeptides, including substance P (SP), thyrotropin-releasing hormone (TRH), neurotensin (NT) and bombesin (BN) on explanted cultures of ventral spinal cord from 13- to 14-day-old rat embryos. In groups, receiving one type of drug only, there was a significant neurite-promo...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90552-1

    authors: Iwasaki Y,Kinoshita M,Ikeda K,Takamiya K,Shiojima T

    更新日期:1989-07-03 00:00:00

  • A dissociation procedure for mammalian taste cells.

    abstract::A procedure for dissociating viable taste cells from the rodent tongue was described. After the tongue was excised, the foliate and circumvallate papillae from the posterior region were blocked to small pieces and incubated for 2-3 h in a calcium-free salt solution containing the enzyme papain. The pieces were then tr...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90202-4

    authors: Herness MS

    更新日期:1989-11-20 00:00:00

  • Thiol redox state (TRS) and oxidative stress in the mouse hippocampus after pentylenetetrazol-induced epileptic seizure.

    abstract::In this study we evaluated oxidative stress (lipid peroxidation and protein oxidation) and thiol redox state [TRS: glutathione (GSH), glutathione disulfide (GSSG), cysteine (CSH), protein (P) thiols (PSH) and protein and non-protein (NP) mixed/symmetric disulfides (PSSR, NPSSR, NPSSC, PSSP)] in hippocampus after penty...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2003.10.080

    authors: Patsoukis N,Zervoudakis G,Panagopoulos NT,Georgiou CD,Angelatou F,Matsokis NA

    更新日期:2004-03-04 00:00:00

  • Striatal extracts promote the dopaminergic differentiation of GFP-bone mesenchymal stem cells.

    abstract::Bone mesenchymal stem cells (BMSCs) are an attractive donor graft source because of the potential of self-renewal and multi-direction differentiation. However, it is a great challenge to induce BMSCs to specifically differentiate to dopamine (DA) neurons for the treatment of Parkinson's disease. Because the striatum i...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.09.063

    authors: Yang S,Gao Q,Bao L,Zhang J,Hu Y,Bing L,Sun J,Hao J,Chen C,Li S,Poon WS,Sun J,Gao Y

    更新日期:2012-11-21 00:00:00

  • Rosuvastatin attenuated the existing morphine tolerance in rats with L5 spinal nerve transection through inhibiting activation of astrocytes and phosphorylation of ERK42/44.

    abstract::Recent studies suggested that statins have anti-inflammatory effects beyond their lipid-lowering properties. In the present study, we sought to investigate whether rosuvastatin could alleviate morphine tolerance by attenuating the glia mediated neuroinflammation in the spinal cord. Using a rat model of L5 spinal nerve...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.11.003

    authors: Li W,Li Y,Zhu S,Ji Q,Shu Y,Zhang L,Liu J

    更新日期:2015-01-01 00:00:00

  • Moderate modulation of disease in the G93A model of ALS by the compound 2-(2-hydroxyphenyl)-benzoxazole (HBX).

    abstract::Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurological disease characterized by degeneration and death of motor neurons. Aberrant protein aggregation and oxidative stress are implicated in the etiology of ALS; thus preventing propagation of early aggregation events and oxidative damage could be an...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.04.035

    authors: Evans TM,Bhattacharya A,Shi Y,Qi W,Block TJ,Chaudhuri A,Chaudhuri AR,Hawker K,Van Remmen H

    更新日期:2016-06-15 00:00:00

  • Improvement of cobalt-transport in axons by complexing agents.

    abstract::The use of the cobalt technique is limited by the fact that cobaltous ions travel within axons for a shorter distance than do other intracellular markers. In the present experiments different organic cobaltous complexes were tested in the rat's sciatic nerve. Cobaltous complexes containing ornithine, threonine, lysine...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(78)90074-5

    authors: Gallyas F,Lénárd L,Lázár G

    更新日期:1978-09-01 00:00:00

  • Effects of movement direction upon kinematic characteristics of vertical arm pointing movements in man.

    abstract::Vertical arm pointing movements in two directions (upwards and downwards), imposing two different loads (unload and 0.5 kg) and speeds (normal and fast) have been studied in six subjects. Movements were recorded using an optoelectronic system. Data analysis concentrated upon finger-tip kinematics. Significant effects ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(98)00604-1

    authors: Papaxanthis C,Pozzo T,Stapley P

    更新日期:1998-09-04 00:00:00

  • Clozapine inhibits isolated N-methyl-D-aspartate receptors expressed in xenopus oocytes in a subunit specific manner.

    abstract::Antipsychotic agents have typically been viewed as acting through dopaminergic targets, although mounting evidence suggests that drugs such as clozapine may act on glutamatergic systems. In order to explore the effects of clozapine on the NMDA class of glutamate receptors, oocytes expressing the NMDA receptor NR1 subu...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(03)00523-8

    authors: Levine JB,Martin G,Wilson A,Treistman SN

    更新日期:2003-08-07 00:00:00