Course corrections of deflected retinal axons on the tectum of the chick embryo.

abstract：:Amyloid beta-peptide (Abeta) deposition in brain is important in the development of Alzheimer's disease (AD). Neprilysin (NEP) appears to be the major Abeta degrading enzyme in vivo and reduced mRNA levels of NEP correlates with increased plaque density. We hypothesized that alterations in the NEP promoter region may ...

journal_title：Neuroscience letters

authors： Lilius L,Forsell C,Axelman K,Winblad B,Graff C,Tjernberg L

更新日期：2003-02-06 00:00:00

abstract：:Hypoxic preconditioning (HP) is a novel strategy to make stem cells resistant to the ischemic environment they encounter after transplantation into injured tissue; this strategy improves survival of both the transplanted cells and the host cells at the injury site. Using both in vitro and in vivo injury models, we con...

journal_title：Neuroscience letters

authors： Oh JS,Ha Y,An SS,Khan M,Pennant WA,Kim HJ,Yoon DH,Lee M,Kim KN

更新日期：2010-03-26 00:00:00

abstract：:The insular cortex (IC) contributes to nociceptive information processing. IC neurons express opioid receptors, including the mu (MOR), kappa (KOR), and delta (DOR) subtypes. Opioidergic agonists suppress excitatory synaptic transmission in the cerebral cortex. In addition, morphine injection into the IC reduces respo...

journal_title：Neuroscience letters

authors： Yokota E,Koyanagi Y,Nakamura H,Horinuki E,Oi Y,Kobayashi M

更新日期：2016-08-15 00:00:00

abstract：:Jet propulsion fuel-8 (JP-8) is the predominant fuel for military land vehicles and aircraft used in the US and NATO. Occupational exposure to jet fuel in military personnel has raised concern for the health risk associated with such exposure in the Department of Defense. Clinical studies of humans chronically exposed...

journal_title：Neuroscience letters

authors： Lin B,Ritchie GD,Rossi J 3rd,Pancrazio JJ

更新日期：2004-06-17 00:00:00

abstract：:By combining techniques designed to increase the amount of horseradish peroxidase (HRP) available for transport and to improve the sensitivity of the reaction for detecting HRP, we have produced an anterograde HRP technique suitable for labeling sparse efferent projections. The efficacy of this light, microscopic tech...

journal_title：Neuroscience letters

authors： West JR,Black AC Jr

更新日期：1979-04-01 00:00:00

abstract：:Ketogenic diets (KD) have shown beneficial effects in terms of anticonvulsant and anti-epileptogenic properties in several experimental models. However, few studies have investigated the consequences of KD with regards to the anti-epileptogenic and neuroprotective effects in kindling-induced seizures. Here, postnatal ...

journal_title：Neuroscience letters

authors： Jiang Y,Yang Y,Wang S,Ding Y,Guo Y,Zhang MM,Wen SQ,Ding MP

更新日期：2012-02-02 00:00:00

abstract：:We and others have previously reported that neurons expressing neuronal nitric oxide synthase (nNOS) do not co-express GTP cyclohydrolase I, the enzyme that synthesize its cofactor tetrahydrobiopterin (BH4). BH4 is released from catecholaminergic cells and nNOS-expressing cells are located close to BH4-producing catec...

journal_title：Neuroscience letters

authors： Choi HJ,Kim SW,Im JH,Lee SG,Kim M,Hwang O

更新日期：2003-12-04 00:00:00

abstract：:A critical component of the cellular stress response, the p53 tumor suppressor protein must be functional for many cancer therapies to be effective. Adjuvant therapies that augment p53 function are predicted to sensitize tumor cells to cancer therapies that rely upon p53 for their efficacy. Of those strategies current...

journal_title：Neuroscience letters

authors： Ghassemifar S,Mendrysa SM

更新日期：2012-03-28 00:00:00

abstract：:In the injured brain, astrocytes become activated and increase GFAP expression; a phenomenon termed as astrogliosis. Previously, we have reported that DJ-1, a Parkinson's disease gene, positively regulates astrogliosis in the injured brain. Moreover, STAT3 is known to play a key role in the regulation of astrogliosis....

journal_title：Neuroscience letters

authors： Choi DJ,Kwon JK,Joe EH

更新日期：2018-10-15 00:00:00

abstract：:Using scanning electron microscopy (SEM), we encountered a new phenomenon in developing olfactory structures. A few cells with single slender processes that sprout from their cell bodies were found lying on the surface of the developing olfactory epithelium in 15 and 16 day old rat embryos. These slender processes res...

journal_title：Neuroscience letters

authors： Menco BP,Jackson JE

更新日期：1997-12-19 00:00:00

abstract：:Around 200,000 veterans (up to 32% of those deployed) of the 1991 Gulf War (GW) suffer from GW illness (GWI), which is characterized by multiple deficits in cognitive, affective, sensory and nociception domains. In this study we employed resting state fMRI (rsfMRI) to map impairments in brain function in GWI with adva...

journal_title：Neuroscience letters

authors： Gopinath KS,Sakoglu U,Crosson BA,Haley RW

更新日期：2019-05-14 00:00:00

abstract：:We investigated the secretion of amyloid beta-protein (beta AP) in a mouse neuronal cell line SN49. SN49 cells stably transfected with mouse beta-amyloid precursor protein (APP) 695 cDNA released approximately three times greater amounts of a 4 kDa protein immunoreactive with anti-beta AP antibodies than untransfected...

journal_title：Neuroscience letters

authors： Araki W,Kunishita T,Takahashi K,Ikeda S,Tabira T

更新日期：1994-02-14 00:00:00

abstract：:Human apolipoprotein E (apoE) exists in three major isoforms encoded by distinct alleles (APOE epsilon2, epsilon3 and epsilon4) and has important functions in nerve development and repair. Inheritance of the 4 allele is a major risk factor for the development of Alzheimer's disease. To investigate the role of APOE pol...

journal_title：Neuroscience letters

authors： Zetterberg H,Palmér M,Ricksten A,Poirier J,Palmqvist L,Rymo L,Zafiropoulos A,Arvanitis DA,Spandidos DA,Blennow K

更新日期：2002-05-24 00:00:00

abstract：:Recently, the gene called DAAO was reported to be associated with schizophrenia in the French Canadian populations. Here, we report a result obtained in the study of our large collection of 547 schizophrenia cases and 536 controls in the Chinese population. Six single-nucleotide polymorphisms (SNPs) were genotyped at ...

journal_title：Neuroscience letters

authors： Liu X,He G,Wang X,Chen Q,Qian X,Lin W,Li D,Gu N,Feng G,He L

更新日期：2004-10-21 00:00:00

abstract：:Many researchers have investigated the variability of discrete goal-directed movements. However, a possible time-dependent property for them has been ignored. We investigated the time-dependent property of the kinematic variability in human rapid goal-directed movements by using fractal analysis. The variability of th...

journal_title：Neuroscience letters

authors： Miyazaki M,Kadota H,Kudo K,Masani K,Ohtsuki T

更新日期：2001-05-25 00:00:00

abstract：:Astrocyte cell cultures were established from human fetal brains and exposed to human recombinant tumor necrosis factor alpha (TNF alpha) and human recombinant interferon gamma (IFN gamma), and the proliferative response was assessed by bromodeoxyuridine-immunostaining technique. TNF alpha showed an inhibitory activit...

journal_title：Neuroscience letters

authors： Moretto G,Yoo A,Kim SU

更新日期：1993-03-05 00:00:00

abstract：:Spinocerebellar ataxia type 17 (SCA17) is an autosomal dominant neurodegenerative disease caused by CAG expansion in the gene encoding the TATA-binding protein (TBP). The neurological features of SCA17 are Purkinje cell loss and gliosis. We have generated SCA17 transgenic mice which recapitulate the patients' phenotyp...

journal_title：Neuroscience letters

authors： Lin CW,Fan CH,Chang YC,Hsieh-Li HM

更新日期：2020-11-01 00:00:00

abstract：:Curcumin is capable of promoting peripheral nerve regeneration in normal condition. However, it is unclear whether its beneficial effect on nerve regeneration still exists under diabetic mellitus. The present study was designed to investigate such a possibility. Diabetes in rats was developed by a single dose of strep...

journal_title：Neuroscience letters

authors： Ma J,Yu H,Liu J,Chen Y,Wang Q,Xiang L

更新日期：2016-01-01 00:00:00

abstract：:Pharmacogenetic studies assessing the role of 5-HT(2A) receptor gene in antipsychotic efficacy yielded conflicting data. Phenotypical heterogeneity of schizophrenia might explain such discrepancies. For example, negative symptoms are known to reflect severity of illness and to restrain therapeutic response. On this ba...

journal_title：Neuroscience letters

authors： Hamdani N,Bonnière M,Adès J,Hamon M,Boni C,Gorwood P

更新日期：2005-03-22 00:00:00

abstract：:Cerebral ischemia/reperfusion involves inflammatory process and naloxone is able to reduce infarct volume and has been used as a therapeutic agent for brain injury. Hypoxia induces the immediate early genes (IEGs) rapidly and transiently that may initiate a cascade of cellular responses that are necessary for survival...

journal_title：Neuroscience letters

authors： Huang HM,Yu JY,Ou HC,Jeng KC

更新日期：2008-06-20 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA), quisqualate, kainate and potassium increased, in a dose-dependent manner, the efflux of radioactivity from rat cerebral cortex minislices preincubated with [3H]choline. Ketamine (1-5 microM) and magnesium (0.1-1 mM) reduced only the release evoked by NMDA. The non-parallel shift of the NMD...

journal_title：Neuroscience letters

authors： Lodge D,Johnston GA

更新日期：1985-05-23 00:00:00

abstract：:A tight coupling between lexico-semantic access and motor control has been established on the basis of neuropsychological, neurophysiological, and behavioral evidence. For example, sensory and motor cortices have been shown to be active when subjects listen to words denoting bodily actions. Kinematic analyses of subje...

journal_title：Neuroscience letters

authors： Shiller DM,Bourguignon N,Frak V,Nazir T,Cadoret G,Robert M,Lemay M

更新日期：2013-10-25 00:00:00

abstract：:The actions of agonists and antagonists of excitatory amino acid receptors were studied in the isolated ileal longitudinal muscle-myenteric plexus preparation of the guinea pig incubated 'in vitro', by recording the contraction of the longitudinal muscle. L-Glutamate, L-aspartate, quinolinate and N-methyl-D-aspartate ...

journal_title：Neuroscience letters

authors： Moroni F,Luzzi S,Franchi-Micheli S,Zilletti L

更新日期：1986-07-11 00:00:00

abstract：:Peripheral nerve damage causes a dramatic alteration to the gene expression in primary sensory neurons, changes within the neuronal cell body giving rise to an altered phenotype, adapted for axonal regeneration. Such changes suggest an alteration in activity, or levels, of cellular transcription factors. The POU famil...

journal_title：Neuroscience letters

authors： Begbie JL,Wood JN,Anderson PN,Latchman DS

更新日期：1996-04-05 00:00:00

abstract：:The normal development of the superior collicular map of auditory space in the guinea pig requires visual experience (Eur. J. Neurosci., 2 (1990) 682-692). The possible role of the visual cortex in this process was assessed by unilateral removal of the cortex prior to the crucial period during which visual experience ...

journal_title：Neuroscience letters

authors： Withington DJ,Binns KE,Keating MJ

更新日期：1991-04-29 00:00:00

abstract：:Pitch and duration -- either as written symbols or in auditory form -- are the basic structural properties in tones that form a melodic sequence. From the cognitive perspective, it is still a matter of debate whether, and at which processing stage, these two factors are processed independently or interdependently. The...

journal_title：Neuroscience letters

authors： Neuhaus C,Knösche TR

更新日期：2008-08-15 00:00:00

abstract：:In order to investigate whether or not nitric oxide (NO) formation underlies the cellular mechanisms of ischemic brain damage, we examined the effects of N omega-nitro-L-arginine (L-NNA), a NO synthase inhibitor, on ischemic brain edema and subsequent infarction in rats with middle cerebral artery occlusion (MCAo). Fo...

journal_title：Neuroscience letters

authors： Nagafuji T,Matsui T,Koide T,Asano T

更新日期：1992-12-07 00:00:00

abstract：:The perception of global coherent motion perception in complex motion patterns containing different direction vectors was investigated. Random dot kinematograms (RDK), plaids and fragmented plaid pattern were presented in which direction vectors of the moving elements were varied. In order to elicit coherent motion pe...

journal_title：Neuroscience letters

authors： Niedeggen M,Wist ER

更新日期：1998-04-24 00:00:00

abstract：:The intracerebroventricular injection of the mast cell degranulator, compound 48/80 (C48/80, 10 micrograms/kg), produced a marked behavioural syndrome in rats which included head and body shakes, paw tremor, excessive grooming, unusual posture and gait, mild diarrhoea, piloerection, extreme agitation and irritability ...

journal_title：Neuroscience letters

authors： Lewis SJ,Quinn MJ,Fennessy MR,Jarrott B

更新日期：1986-03-28 00:00:00

abstract：:The nuclear factor kappa B inducing kinase gene (NIK) is located near the region of the haplotype associated with progressive supranuclear palsy (PSP) in chromosome 17q. We have analysed the coding region of the NIK gene in PSP patients through single strand conformation polymorphism and direct sequencing, in order to...

journal_title：Neuroscience letters

authors： Campdelacreu J,Ezquerra M,Muñoz E,Oliva R,Tolosa E

更新日期：2003-04-10 00:00:00