MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells.

abstract：:A dimeric form of acetylcholinesterase from the electric organ of Torpedo californica was solubilized by phosphatidylinositol-specific phospholipase C from Staphylococcus aureus. The solubilized enzyme had a sedimentation coefficient of 7.3S which was not modified by detergents. The high salt-soluble asymmetric forms ...

journal_title：Neuroscience letters

authors： Futerman AH,Low MG,Silman I

更新日期：1983-09-19 00:00:00

abstract：:After hypoxic-ischemic insult iron deposited in the brain catalyzes formation of reactive oxygen species. Newborn rats, showing reduced physiological body temperature and their hyperthermic counterparts injected with deferoxamine (DF), a chelator of iron, are protected both against iron-mediated neurotoxicity and agai...

journal_title：Neuroscience letters

authors： Kletkiewicz H,Nowakowska A,Siejka A,Mila-Kierzenkowska C,Woźniak A,Caputa M,Rogalska J

更新日期：2016-08-15 00:00:00

abstract：:We used the mismatch negativity event-related potential to examine how spatial location and feature variation affect the capacity of the auditory system to automatically respond to pairs of rapid (180 ms apart) acoustic changes within a single tone. When a tone first deviated from a standard tone in source location an...

journal_title：Neuroscience letters

authors： Deouell LY,Karns CM,Harrison TB,Knight RT

更新日期：2003-01-02 00:00:00

abstract：:Increasing evidence suggests a relation between vascular disorders and late-onset Alzheimer's disease (AD). We performed an association analysis of low-density lipoprotein receptor-related protein (LRP), lipoprotein lipase (LPL), and angiotensin converting enzyme (ACE) genes, known to be involved in vascular disorders...

journal_title：Neuroscience letters

authors： Myllykangas L,Polvikoski T,Sulkava R,Verkkoniemi A,Tienari P,Niinistö L,Kontula K,Hardy J,Haltia M,Pérez-Tur J

更新日期：2000-10-13 00:00:00

abstract：:The cellular localisation of benzodiazepine receptors was studied. Kainic acid induced neuronal lesions (2 x 0.25-2 x 2 micrograms; 2-26 days in rat cerebellum decreased specific binding of [3H]flunitrazepam down to 35% of controls. Specific binding of [3H]flunitrazepam was also decreased (to 80% of controls) in the c...

journal_title：Neuroscience letters

authors： Braestrup C,Nielsen M,Biggio G,Squires RF

更新日期：1979-08-01 00:00:00

abstract：:Central administration of C-type natriuretic peptide (CNP) affects various neuroendocrine systems. In the present study, we examined whether CNP acts directly on arginine-vasopressin (AVP) secretion from rat supraoptic nucleus (SON) neurons, using acute dissociated cell preparations. CNP inhibited the basal secretion ...

journal_title：Neuroscience letters

authors： Yamamoto S,Morimoto I,Yanagihara N,Kangawa K,Inenaga K,Eto S,Yamashita H

更新日期：1997-06-27 00:00:00

abstract：:Nuclear factor-kappa B (NF-kappa B) DNA binding factor is an inducible transcription factor that responds to various cellular signals. Levels of cortical NF-kappa B DNA binding activity were measured in a controlled lateral cortical impact model of traumatic brain injury (TBI) in rats. Using electrophoretic mobility s...

journal_title：Neuroscience letters

authors： Yang K,Mu XS,Hayes RL

更新日期：1995-09-08 00:00:00

abstract：:In the presence of atropine electrical transmural stimulation (using repetitive volleys, e.g. 3 pulses at 50 Hz applied every 4 s) of full thickness longitudinal strips of guinea-pig ileum produced non-cholinergic excitatory junction potentials (EJPs) and inhibitory junction potentials (IJPs) in the circular muscle la...

journal_title：Neuroscience letters

authors： Taylor GS,Bywater RA

更新日期：1986-01-02 00:00:00

abstract：:Early intervention following combat deployment has the potential to prevent posttraumatic stress disorder (PTSD), but there is a need for greater understanding of the factors that contribute to PTSD symptom progression. This study investigated: (1) fear-potentiated startle during a fear extinction, (2) white matter mi...

journal_title：Neuroscience letters

authors： Costanzo ME,Jovanovic T,Pham D,Leaman S,Highland KB,Norrholm SD,Roy MJ

更新日期：2016-04-08 00:00:00

abstract：:The influence of monokines and CNS-derived colony-stimulating factors (CSF) on the growth of microglia has been studied in mixed glial primary cultures stemming from mouse embryos. We observed that spontaneous growth of microglial cells in the presence of astrocytes is blocked by adding anti-colony-stimulating factor ...

journal_title：Neuroscience letters

authors： Théry C,Mallat M

更新日期：1993-02-19 00:00:00

abstract：BACKGROUND:Brain function relies on the capacity of neurons to locally modulate each other at the level of synapses. Therefore, the exosomal pathway may constitute a well-designed mechanism for local and systemic interneuronal transfer of information within functional brain networks. Exosomes bind to and are endocytose...

journal_title：Neuroscience letters

authors： Yu X,Abdul M,Fan BQ,Zhang L,Lin X,Wu Y,Fu H,Lin Q,Meng H

更新日期：2020-04-01 00:00:00

abstract：:Plasminogen belongs to the plasminogen activator system of cell signaling proteins and has recently been identified to bind to pathological prion protein PrPSC, but not to its normal conformer, PrPC. Plasminogen binds specifically to the urokinase-type plasminogen activator receptor (uPAR) to promote pericellular prot...

journal_title：Neuroscience letters

authors： Deininger MH,Trautmann K,Magdolen V,Luther T,Schluesener HJ,Meyermann R

更新日期：2002-05-10 00:00:00

abstract：:Thyroid hormone metabolism was investigated in the frontal cortex and amygdala in groups of rats either 'behaviorally dependent' on ethanol or chronically exposed to ethanol, but not 'dependent'. The activities of the 5'II deiodinase isoenzyme, which catalyzes the deiodination of thyroxine (T4) to the active metabolit...

journal_title：Neuroscience letters

authors： Baumgartner A,Eravci M,Pinna G,Hiedra L,Prengel H,Brödel O,Meinhold H

更新日期：1997-05-09 00:00:00

abstract：:Cochlear hair cell loss results in the secondary loss of spiral ganglion cells (SGCs). The death of these SGCs is due to apoptosis. The E2F1-cyclin dependent kinase 1 (CDK1) pathway is believed to represent an important mechanism of neuronal cell death. However, the role of this pathway in spiral ganglion neuronal apo...

journal_title：Neuroscience letters

authors： Liu YY,Wang GP,Peng Z,Guo JY,Wu Q,Xie J,Gong SS

更新日期：2016-03-23 00:00:00

abstract：:There is a growing interest for using quantitative EEG and LORETA current source density in clinical and research settings. Importantly, if these indices are to be employed in clinical settings then the reliability of these measures is of great concern. Neuroguide (Applied Neurosciences) is sophisticated software deve...

journal_title：Neuroscience letters

authors： Cannon RL,Baldwin DR,Shaw TL,Diloreto DJ,Phillips SM,Scruggs AM,Riehl TC

更新日期：2012-06-14 00:00:00

abstract：:Mitochondrial Ca(2+) controls numerous cell functions, such as energy metabolism, reactive oxygen species generation, spatiotemporal dynamics of Ca(2+) signaling, cell growth and death in various cell types including neurons. Mitochondrial Ca(2+) accumulation is mainly mediated by the mitochondrial Ca(2+) uniporter (M...

journal_title：Neuroscience letters

authors： Jakob R,Beutner G,Sharma VK,Duan Y,Gross RA,Hurst S,Jhun BS,O-Uchi J,Sheu SS

更新日期：2014-07-11 00:00:00

abstract：:The fundamental pathological process(es) associated with schizophrenia (SZ) remain(s) uncertain, but multiple lines of evidence suggest that this condition is associated with excessive stimulation of striatal dopamine (DA) D2 receptors, deficient stimulation of medial prefrontal cortex (mPFC) D1 receptors as well as n...

journal_title：Neuroscience letters

authors： Zhang L,Zhou R,Xiang G

更新日期：2005-08-05 00:00:00

abstract：:A dose-dependent loss of vanilloid receptors (specific [3H]resiniferatoxin binding sites) was found in sensory ganglia of rats 24 h after s.c. administration of resiniferatoxin (RTX), an ultrapotent capsaicin analog. This receptor loss displayed an ED50 of 30 micrograms/kg both in dorsal root and trigeminal ganglia; t...

journal_title：Neuroscience letters

authors： Szallasi A,Blumberg PM

更新日期：1992-06-08 00:00:00

abstract：:A novel preparation for the study of male and female sexual function in anesthetized, acutely spinalized rats is reported. In both sexes, the coitus reflex (the neuromuscular concomitants of sexual climax) could be elicited by mechanical stimulation of the distal urethra. It is concluded that the spinal sexual circuit...

journal_title：Neuroscience letters

authors： Chung SK,McVary KT,McKenna KE

更新日期：1988-12-05 00:00:00

abstract：:Hippocampal volumetry has been proposed to aid in the early diagnosis of Alzheimer's disease (AD) and to monitor progression of the disease. While this is believed to be as a result of hippocampal neuron loss, this association has not been firmly established and loss of other tissue elements may be responsible for the...

journal_title：Neuroscience letters

authors： Kril JJ,Hodges J,Halliday G

更新日期：2004-05-06 00:00:00

abstract：:The pattern and distribution of the cortical projections from intermediate parts of the cholinergic basal magnocellular nucleus were studied by anterogradely transported Phaseolus vulgaris-leucoagglutinin. This immunocytochemical tracing technique reveals the detailed morphology and distribution of efferents from this...

journal_title：Neuroscience letters

authors： Luiten PG,Spencer DG Jr,Traber J,Gaykema RP

更新日期：1985-06-12 00:00:00

abstract：:Treatment with dopamine and other dopamine D2 receptor agonists has been shown to induce cell death through activation of caspase-3 pathway. However, initial step that leads to the activation of caspase-3 in D2 receptor-mediated apoptotic pathway remains unclear. Recently, it was shown that a spliced variant of Galpha...

journal_title：Neuroscience letters

authors： López-Aranda MF,Navarro-Lobato I,López-Téllez JF,Blanco E,Masmudi-Martín M,Khan ZU

更新日期：2008-07-04 00:00:00

abstract：:Loss of ganglion cells is a common and irreversible complication of hair cell loss in the cochlea. Gene transfer could potentially be used to prevent this neuronal degeneration and other pathologies in the cochlea. Human adenoviruses should provide a feasible gene transfer vehicle for transducing the quiescent cochlea...

journal_title：Neuroscience letters

authors： Raphael Y,Frisancho JC,Roessler BJ

更新日期：1996-03-29 00:00:00

abstract：:Tonsils have a privileged situation in the immune system in that they are in touch with the environment. Melatonin is a hormone that is influenced by the circadian environmental variations of dark-light and is a modulator of the immune system. We have studied a group of thirty five children with recurrent acute tonsil...

journal_title：Neuroscience letters

authors： Lopez-Gonzalez MA,Guerrero JM,Sanchez B,Delgado F

更新日期：1998-05-15 00:00:00

abstract：:In an attempt to examine a possible relationship between heat shock stress and an induction of amyloid precursor protein, cultured lymphoblastoid cells established from 12 human subjects were treated with heat shock at 42 degrees C for 30 min. The levels of mRNA for amyloid precursor protein (APP), heat shock protein ...

journal_title：Neuroscience letters

authors： Abe K,St George-Hyslop PH,Tanzi RE,Kogure K

更新日期：1991-04-29 00:00:00

abstract：:Fish glial cells were obtained from cultivated segments of the optic nerve and raised in vitro. Two types of cells were identified as astrocyte- and oligodendrocyte-like glia by the monoclonal antibody Mab O1 (specific for oligodendrocytes) and the rabbit serum anti-goldfish glial fibrillary acidic protein (anti-G-GFA...

journal_title：Neuroscience letters

authors： Bastmeyer M,Beckmann M,Nona SM,Cronly-Dillon JR,Stuermer CA

更新日期：1989-06-19 00:00:00

abstract：:The content of the neurosteroids, dehydroepiandrosterone (DHEA) in the brain decreases with aging. Also the oxidative energy metabolism is known to decrease with aging. Hence we examined the effects of treatment with DHEA (0.2 or 1.0 mg/kg body weight for 7 days) on oxidative energy metabolism in brain mitochondria fr...

journal_title：Neuroscience letters

authors： Patel MA,Katyare SS

更新日期：2006-07-10 00:00:00

abstract：:A brief hammer tap applied passively (by the experimenter) to the forearm elicits a short-latency reflex response in the forearm flexors and extensors. When the same tap is performed actively (by the subject) using the opposite forearm, the reflex response is preceded by a short-lasting anticipatory reduction in the m...

journal_title：Neuroscience letters

authors： Struppler A,Gerilovsky L,Jakob C

更新日期：1993-09-03 00:00:00

abstract：:Gastrin releasing peptide (GRP) is involved in the stimulation of gastric acid release from the stomach. It also mediates effects on feeding behavior. It is associated with anorexigenic effects in both mammalian and avian species, but the mechanism of action is unknown in any species. The aim of the present study was ...

journal_title：Neuroscience letters

authors： Bohler M,Dougherty C,Tachibana T,Gilbert ER,Cline MA

更新日期：2019-11-20 00:00:00

abstract：:We used an intracellular microelectrode technique to study the mechanisms of action of two isoforms (human and rat) of calcitonin gene-related peptide (CGRP) on the evoked and spontaneous quantal secretion of acetylcholine (ACh) in mouse diaphragm motor synapses. Recordings of miniature endplate potentials (MEPPs) and...

journal_title：Neuroscience letters

authors： Gaydukov AE,Bogacheva PO,Balezina OP

更新日期：2016-08-15 00:00:00