White matter microstructure of the uncinate fasciculus is associated with subthreshold posttraumatic stress disorder symptoms and fear potentiated startle during early extinction in recently deployed Service Members.

Abstract:

:Early intervention following combat deployment has the potential to prevent posttraumatic stress disorder (PTSD), but there is a need for greater understanding of the factors that contribute to PTSD symptom progression. This study investigated: (1) fear-potentiated startle during a fear extinction, (2) white matter microstructure, and (3) PTSD symptom severity, in 48 recently deployed service members (SMs) who did not have sufficient PTSD symptoms to meet criteria for a clinical diagnosis. Electromyography startle during a conditional discrimination paradigm, diffusion tensor imaging, and the Clinician Administered PTSD Scale were assessed in a cohort of SMs within 2 months after their return from Iraq or Afghanistan. Significant correlations were found between left uncinate fasciculus (UF) white matter tract integrity and total PTSD symptoms, r=-0.343, p=0.018; the left UF and hyperarousal symptoms, r=-0.29, p=0.047; right UF integrity and total PTSD symptoms r=-0.3371, p=0.01; right UF integrity and hyperarousal symptoms r=-0.332, p=0.023; left UF and startle during early extinction, r=.31, p=0.033. Our results indicate that compromise of UF tract frontal-limbic connections are associated with greater PTSD symptom severity and lower startle response during extinction. In a subthreshold population, such a relationship between brain structure, physiological reactivity, and behavioral expression may reveal vulnerabilities that could have significant implications for PTSD symptom development.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Costanzo ME,Jovanovic T,Pham D,Leaman S,Highland KB,Norrholm SD,Roy MJ

doi

10.1016/j.neulet.2016.02.041

subject

Has Abstract

pub_date

2016-04-08 00:00:00

pages

66-71

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(16)30107-0

journal_volume

618

pub_type

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