Abstract:
:Focal brain lesions such as cortical dysplasia and glioneural tumors generate epileptic activity and thus may be synaptically connected with normal cortex. To test this hypothesis, we compared event-related potentials recorded directly from the medial temporal lobe (MTL) and a dysplastic lesion in eight patients with intractable temporal lobe epilepsy. The P3 component, related to visual target detection, showed different peak latencies in four patients and a larger intralesional amplitude compared to established anterior-MTL-generators in two patients. Semantic processing was identified by the N400 component and showed a different latency in four patients and larger intralesional amplitudes in two patients. These results are compatible with the hypothesis that cortical lesions interact with synaptic pathways related to cognitive functions such as visual target detection, and verbal processing.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kirschstein T,Fernández G,Grunwald T,Pezer N,Urbach H,Blümcke I,Van Roost D,Lehnertz K,Elger CEdoi
10.1016/s0304-3940(02)01398-8keywords:
subject
Has Abstractpub_date
2003-03-06 00:00:00pages
237-41issue
3eissn
0304-3940issn
1872-7972pii
S0304394002013988journal_volume
338pub_type
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