Heterotopias, cortical dysplasias and glioneural tumors participate in cognitive processing in patients with temporal lobe epilepsy.

Abstract:

:Focal brain lesions such as cortical dysplasia and glioneural tumors generate epileptic activity and thus may be synaptically connected with normal cortex. To test this hypothesis, we compared event-related potentials recorded directly from the medial temporal lobe (MTL) and a dysplastic lesion in eight patients with intractable temporal lobe epilepsy. The P3 component, related to visual target detection, showed different peak latencies in four patients and a larger intralesional amplitude compared to established anterior-MTL-generators in two patients. Semantic processing was identified by the N400 component and showed a different latency in four patients and larger intralesional amplitudes in two patients. These results are compatible with the hypothesis that cortical lesions interact with synaptic pathways related to cognitive functions such as visual target detection, and verbal processing.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Kirschstein T,Fernández G,Grunwald T,Pezer N,Urbach H,Blümcke I,Van Roost D,Lehnertz K,Elger CE

doi

10.1016/s0304-3940(02)01398-8

keywords:

subject

Has Abstract

pub_date

2003-03-06 00:00:00

pages

237-41

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394002013988

journal_volume

338

pub_type

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