当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat.

Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat.

Abstract：

:Very recent studies in adult gerbils and rats have shown that exposure to sublethal ischemia can confer neuroprotection from subsequent lethal ischemic episodes. To determine if a similar phenomenon can be elicited during the perinatal period, we have developed a preconditioning regimen that involves exposure to normothermic hypoxia (8% oxygen) 24 h prior to hypoxia-ischemia in the well-established post-natal-day 7 rat pup model [20]. Significant infarction, manifested as a 34 +/- 4% reduction in cerebral hemispheric weight ipsilateral to the carotid ligation, was noted in control animals (n = 24) one week after hypoxia-ischemia, whereas littermates preconditioned with 3 h hypoxia (n = 29) showed no evidence of hemispheric necrosis. Lack of injury in the latter animals was confirmed at the cellular level by histopathologic analyses of Nissl-stained coronal sections. Thus, pre-exposure to hypoxia induces endogenous adaptive mechanisms that can protect the perinatal brain from hypoxic-ischemic injury.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Gidday JM,Fitzgibbons JC,Shah AR,Park TS

doi

10.1016/0304-3940(94)90455-3

subject

Has Abstract

pub_date

1994-02-28 00:00:00

pages

221-4

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(94)90455-3

journal_volume

168

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation.

    abstract：:Brain pericytes are involved in neurovascular dysfunction, neurodegeneration and/or neuroinflammation. In the present study, we focused on the proinflammatory properties of brain pericytes to understand their participation in the induction of inflammation at the neurovascular unit (NVU). The NVU comprises different ce...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.06.052

    authors： Matsumoto J,Takata F,Machida T,Takahashi H,Soejima Y,Funakoshi M,Futagami K,Yamauchi A,Dohgu S,Kataoka Y

    更新日期：2014-08-22 00:00:00

  • c-Jun, krox-20, and integrin beta4 expression following chronic nerve compression injury.

    abstract：:Limited work has been done to investigate the molecular mechanisms behind the process of demyelination and remyelination that occurs in response to chronic nerve compression (CNC) injury. In the present study, we investigated the expression of the transcription factors krox-20 and c-jun, positive and negative regulato...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.09.014

    authors： Pham K,Nassiri N,Gupta R

    更新日期：2009-11-13 00:00:00

  • Feeling vibrations: enhanced tactile sensitivity in congenitally deaf humans.

    abstract：:The human nervous system displays remarkable functional plasticity following long-term sensory deprivation. For example, the auditory cortex of congenitally deaf humans may start to process tactile information. To further explore this type of cross-modal plasticity, we examined the tactile accuracy of congenitally dea...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)01597-x

    authors： Levänen S,Hamdorf D

    更新日期：2001-03-23 00:00:00

  • Regionally specific age-dependent decline in alpha 2-adrenoceptors: an autoradiographic study in human brain.

    abstract：:The effect of sex, postmortem delay and aging on alpha 2-adrenoceptor binding was studied in tissue sections from several representative regions of the human brain from 21 subjects using [3H]UK-14304 as a ligand. Sex and postmortem delay did not influence the density of alpha 2-receptors. Aging resulted in clear decre...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90588-k

    authors： Pascual J,del Arco C,González AM,Díaz A,del Olmo E,Pazos A

    更新日期：1991-12-09 00:00:00

  • Central 6-hydroxydopamine lesions decrease mineralocorticoid, but not glucocorticoid receptor gene expression in the rat hippocampus.

    abstract：:The role of hippocampal noradrenergic inputs in the modulation of corticosteroid receptor expression has been investigated. Adult male rats were given central 6-hydroxydopamine (6-OHDA) and the expression of hippocampal mineralocorticoid (MR) and glucocorticoid (GR) receptor mRNA was examined after two weeks by in sit...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(92)90363-c

    authors： Yau JL,Seckl JR

    更新日期：1992-08-17 00:00:00

  • Imidacloprid acts as an antagonist on insect nicotinic acetylcholine receptor containing the Y151M mutation.

    abstract：:Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels which mediate fast cholinergic synaptic transmission in insect and vertebrate nervous systems. A point mutation Y151S had been identified in Nilaparvata lugens (brown planthopper) that is associated with target-site resistance to neonicotinoid in...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.09.039

    authors： Zhang Y,Liu S,Gu J,Song F,Yao X,Liu Z

    更新日期：2008-12-03 00:00:00

  • Cortical neuronal ensembles driven by dorsal horn spinal neurones with spontaneous activity in the cat.

    abstract：:Simultaneous recordings of cortical activity, recorded as the cortical local field potential (CLFP) in the contralateral posterior sigmoid gyrus, and the spinal activity, recorded as the cord dorsum potential (CDP) of the L6 lumbar segment, were made in the anaesthetized cat. The electrodes were positioned in somatose...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)02497-1

    authors： Manjarrez E,Rojas-Piloni G,Vazquez D,Flores A

    更新日期：2002-02-01 00:00:00

  • Toward the development of a sensitive, pre-clinical screen for neurological diseases from spontaneous neural coordination in juvenile and young-adult C57BK6 mice.

    abstract：:Spontaneous Frequency Bursts (SFBs) are a newly discovered form of long-distance neural coordination. They have several distinctive properties, including near-simultaneity of occurrence (+/-25-50 ms) across distant brain regions and high within- and across-site coherence in multiple low and high frequency bands, presu...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.01.014

    authors： Robson J,Mehta N,Polcz JE,Hermer L

    更新日期：2010-03-03 00:00:00

  • Correlation of increased hippocampal Sumo3 with spatial learning ability in old C57BL/6 mice.

    abstract：:Age-related impairment of learning and memory is a common phenomenon in humans and animals, yet the underlying mechanism remains unclear. We hypothesize that a small ubiquitin-related modifier (Sumo) might correlate with age-related loss of learning and memory. To test this hypothesis, the present study evaluated age-...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.04.051

    authors： Yang QG,Wang F,Zhang Q,Xu WR,Chen YP,Chen GH

    更新日期：2012-06-19 00:00:00

  • mTOR activates hypoxia-inducible factor-1α and inhibits neuronal apoptosis in the developing rat brain during the early phase after hypoxia-ischemia.

    abstract：:The mammalian target of rapamycin (mTOR) exerts neuroprotective effects under hypoxic or ischemic conditions. To explore whether mTOR participates in neuroprotective signaling through regulation of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and neuronal apoptosis in developing rat ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.11.058

    authors： Chen H,Xiong T,Qu Y,Zhao F,Ferriero D,Mu D

    更新日期：2012-01-24 00:00:00

  • Peroxynitrite-induced modification of the N-methyl-D-aspartate receptor in the cerebral cortex of the guinea pig fetus at term.

    abstract：:The present study tests the hypothesis that nitration is a potential mechanism of N-methyl-D-aspartate (NMDA) receptor modification, by assessing the effect of peroxynitrite in vitro on the glutamate and ion-channel sites of the NMDA receptor in the fetal guinea pig. Nitration of NMDA receptor subunits was confirmed b...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)01608-6

    authors： Zanelli SA,Ashraf QM,Delivoria-Papadopoulos M,Mishra OP

    更新日期：2000-12-15 00:00:00

  • Radioautographic evidence that axons from the area of supraoptic nuclei in the rat project to extrahypothalamic brain regions.

    abstract：:The axonal efferents of neurons of the supraoptic nucleus area were studied by radioautography in the rat after discrete stereotaxic injections of [3H]leucine into this nucleus. Beside a densely labeled pathway running from the nucleus to the posterior pituitary through the internal median eminence, several of the vis...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90027-3

    authors： Alonso G,Szafarczyk A,Assenmacher I

    更新日期：1986-05-23 00:00:00

  • Expression of functional metabotropic and ionotropic glutamate receptors in baculovirus-infected insect cells.

    abstract：:An ionotropic glutamate receptor of the kainate subtype (GluR6) and a G-protein coupled metabotropic glutamate receptor (mGluR1 alpha) were expressed and studied in two insect cell lines: sf9 cells from Spodoptera frugiperda and MG1 cells from Trichoplusia ni. Application of kainate to GluR6-infected MG1 cells produce...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(94)90168-6

    authors： Ross SM,Taverna FA,Pickering DS,Wang LY,MacDonald JF,Pennefather PS,Hampson DR

    更新日期：1994-05-23 00:00:00

  • Early induction of c-Myc is associated with neuronal cell death.

    abstract：:Neuronal cell cycle activation has been implicated in neurodegenerative diseases such as Alzheimer's disease, while the initiating mechanism of cell cycle activation remains to be determined. Interestingly, our previous studies have shown that cell cycle activation by c-Myc (Myc) leads to neuronal cell death which sug...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.10.004

    authors： Lee HP,Kudo W,Zhu X,Smith MA,Lee HG

    更新日期：2011-11-14 00:00:00

  • Protective effect of carnosine on febrile seizures in immature mice.

    abstract：:Febrile seizures (FSs) are the most common type of convulsions in childhood and complex FSs represent an increased risk for development of temporal lobe epilepsy. The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia ind...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.12.061

    authors： Dai YJ,Wu DC,Feng B,Hou WW,Xu CL,Ohtsu H,Chen Z,Hu WW

    更新日期：2015-02-19 00:00:00

  • Involvement of extracellular matrix in acetylcholine receptor epsilon-subunit gene expression at the rat neuromuscular junction.

    abstract：:During neuromuscular development, the nerve induces the expression of acetylcholine receptor (AChR) epsilon-subunit gene selectively in synaptic myonuclei. Here we show that even after elimination of neural effects by denervation, synaptic expression of epsilon-subunit transcripts is maintained for > 4 months. In cont...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(95)11661-f

    authors： Herczeg A,Jones G,Brenner HR

    更新日期：1995-06-23 00:00:00

  • Dilation of the inferior colliculus and hypersensitivity to sound in Wnt1-cre and Wnt1-GAL4 double-transgenic mice.

    abstract：:The processing of sound information is mediated by the cochlea and the central auditory system. Among the central auditory system, the inferior colliculus (IC) has leading roles in the acoustic processing. In a previous study, we demonstrated psychiatric disorder-related behavioral abnormalities in a genetically modif...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.02.061

    authors： Nakajima M,Nishikawa C,Miyasaka Y,Kikkawa Y,Mori H,Tsuruta M,Okuyama S,Furukawa Y

    更新日期：2014-04-30 00:00:00

  • ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17.

    abstract：:Spinocerebellar ataxia type 17 (SCA17) is an autosomal dominant neurodegenerative disease caused by CAG expansion in the gene encoding the TATA-binding protein (TBP). The neurological features of SCA17 are Purkinje cell loss and gliosis. We have generated SCA17 transgenic mice which recapitulate the patients' phenotyp...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2020.135337

    authors： Lin CW,Fan CH,Chang YC,Hsieh-Li HM

    更新日期：2020-11-01 00:00:00

  • The effects of combining chondroitinase ABC and NEP1-40 on the corticospinal axon growth in organotypic co-cultures.

    abstract：:The area surrounding the injured spinal cord is a non-permissive milieu for axonal growth due to the inhibitory factors, especially chondroitin sulfate proteoglycan (CSPG) and Nogo. Recent studies have reported that chondroitinase ABC (ChABC) or Nogo-66(1-40) antagonist peptide (NEP1-40) promote axonal growth after sp...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.03.049

    authors： Nakamae T,Tanaka N,Nakanishi K,Kamei N,Sasaki H,Hamasaki T,Yamada K,Yamamoto R,Izumi B,Ochi M

    更新日期：2010-05-26 00:00:00

  • Anatomical evidence for inputs to ventrolateral medullary catecholaminergic neurons from the midbrain periaqueductal gray of the rat.

    abstract：:Previous studies have shown that the midbrain periaqueductal gray (PAG) projects to the ventrolateral medulla (VLM). Here, we studied PAG projections to the area of A1/C1 neurons in the VLM in the rat using phaseolus vulgaris leucoagglutinin (PHA-L) anterograde tracing combined with immunocytochemistry for tyrosine hy...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(94)11788-k

    authors： Chen S,Aston-Jones G

    更新日期：1995-08-04 00:00:00

  • No mutation in the entire coding region of the alpha-synuclein gene in pathologically confirmed cases of multiple system atrophy.

    abstract：:To determine whether mutations in the coding region of the alpha-synuclein gene are relevant in cases of multiple system atrophy (MSA), detailed nucleotide sequence analysis of the alpha-synuclein gene was performed using total RNA obtained from autopsied brain specimens of 11 pathologically confirmed cases of MSA. Th...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(99)00475-9

    authors： Ozawa T,Takano H,Onodera O,Kobayashi H,Ikeuchi T,Koide R,Okuizumi K,Shimohata T,Wakabayashi K,Takahashi H,Tsuji S

    更新日期：1999-07-30 00:00:00

  • A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.

    abstract：:Recently, we demonstrated that dimeric apocynin prevented loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic (tg) mouse (treated with 200mg/kg, three times per week) [B.P. Dranka et al., Neurosci. Lett. 549 (2013) 57-62]. Here we extend those studies by treating LRRK2(R1441G) mice wi...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.09.042

    authors： Dranka BP,Gifford A,McAllister D,Zielonka J,Joseph J,O'Hara CL,Stucky CL,Kanthasamy AG,Kalyanaraman B

    更新日期：2014-11-07 00:00:00

  • GABA(B) receptors in the nucleus tractus solitarii modulate the carotid chemoreceptor reflex in rats.

    abstract：:In urethane-chloralose anesthetized rats, the role of GABA(B) receptor in the commissural subnucleus of the nucleus tractus solitarii (commNTS) on the carotid chemoreceptor reflex was investigated. Microinjection of a GABA(B) agonist baclofen into the commNTS did not have any effects on arterial blood pressure (BP) or...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(98)00942-2

    authors： Suzuki M,Tetsuka M,Endo M

    更新日期：1999-01-22 00:00:00

  • p300 activation by Presenilin 1 but not by its M146L mutant.

    abstract：:The transcriptional co-activator p300 plays an important role in regulating gene expression in a number of different cell types. We have shown that wild type (WT) Presenilin 1 (PS1) stimulates the transcriptional activity ability of CREB Binding Protein (CBP), a close homolog of p300, whereas the Alzheimer's disease (...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.11.036

    authors： Francis YI,Diss JK,Kariti M,Stephanou A,Latchman DS

    更新日期：2007-02-14 00:00:00

  • Association of interleukin-1 beta polymorphisms with idiopathic Parkinson's disease.

    abstract：:Activated microglia surround degenerating substantia nigra neurons in Parkinson's disease (PD). Such microglia produce high levels of interleukin-1 beta (IL-1 beta) and interleukin-1 alpha (IL-1 alpha). T and C alleles exist for the IL-1 beta-511 regulatory region as well as for the IL-1 alpha-889 regulatory region. T...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)00300-2

    authors： McGeer PL,Yasojima K,McGeer EG

    更新日期：2002-06-21 00:00:00

  • Accelerated functional recovery and neuroprotection by agmatine after spinal cord ischemia in rats.

    abstract：:Treatment with agmatine, decarboxylated arginine, proved to be non-toxic and to exert neuroprotective effects in several models of neurotoxic and ischemic brain and spinal cord injuries. Here we sought to find out whether agmatine treatment would also prove beneficial in a rat spinal cord ischemia model (balloon occlu...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)01625-6

    authors： Gilad GM,Gilad VH

    更新日期：2000-12-22 00:00:00

  • A property of face representation at the categorical level.

    abstract：:Face processing is unique to human beings and is likely to have special neuronal properties. We studied one of these properties, categorical representation of the face in perception processing (perception) and in memory recall processing (imagery), using the face and building stimuli. The same building-selective areas...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.09.053

    authors： Sung YW,Ogawa S

    更新日期：2008-12-19 00:00:00

  • In vivo release of enkephalin from the globus pallidus.

    abstract：:Push-pull cannulae were acutely positioned through previously implanted guides in the globus pallidus of unanesthetized freely moving cats and rats. During slow-flow perfusions, enkephalin release was detected in resting conditions and increased more than 3-fold when both 50 mM K+ and 1.8 mM Ca2+ were present in the p...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(81)90360-8

    authors： Bayon A,Shoemaker WJ,Lugo L,Azad R,Ling N,Drucker-Colin RR,Bloom FE

    更新日期：1981-06-12 00:00:00

  • Synergistic stimulation, by tumor necrosis factor-alpha and interferon-gamma, of fractalkine expression in human astrocytes.

    abstract：:Fractalkine is a CX3C chemonkine that appears to be a neuron-to-microglia signal molecule in the central nervous system. We studied the expression of fractalkine in normal human astrocytes in culture, by using semi-quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. We f...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)01699-8

    authors： Yoshida H,Imaizumi T,Fujimoto K,Matsuo N,Kimura K,Cui X,Matsumiya T,Tanji K,Shibata T,Tamo W,Kumagai M,Satoh K

    更新日期：2001-05-04 00:00:00

  • Serotonergic control of phrenic motoneuronal activity at the level of the spinal cord of the rabbit.

    abstract：:The role of serotonin (5-hydroxytryptamine, 5-HT)-mediated modulation of phrenic motoneuronal activity was evaluated by microapplication of 5-HT and methysergide into the phrenic nuclei of the rabbit. 5-HT facilitated phrenic nerve activity (PNA) considerably resulting in a long-lasting augmentation of the peak amplit...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(90)90411-2

    authors： Schmid K,Böhmer G,Merkelbach S

    更新日期：1990-08-14 00:00:00