Abstract:
:Fractalkine is a CX3C chemonkine that appears to be a neuron-to-microglia signal molecule in the central nervous system. We studied the expression of fractalkine in normal human astrocytes in culture, by using semi-quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. We found that tumor-necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) synergistically enhance the expression of fractalkine. The expression of both fractalkine mRNA and protein was increased in time- and concentration-dependent manners in the cells co-stimulated with TNF-alpha and IFN-gamma. Cycloheximide, an inhibitor of protein synthesis, and dexamethasone had no effect on the synergy of the stimulation of fractalkine expression. We conclude that normal human astrocytes produce fractalkine by co-stimulation with pro-inflammatory cytokines and it may serve as a potential signal for immune and inflammatory responses in the central nervous system.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Yoshida H,Imaizumi T,Fujimoto K,Matsuo N,Kimura K,Cui X,Matsumiya T,Tanji K,Shibata T,Tamo W,Kumagai M,Satoh Kdoi
10.1016/s0304-3940(01)01699-8keywords:
subject
Has Abstractpub_date
2001-05-04 00:00:00pages
132-6issue
2eissn
0304-3940issn
1872-7972pii
S0304394001016998journal_volume
303pub_type
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