Asymmetries of prefrontal cortex in human episodic memory: effects of transcranial magnetic stimulation on learning abstract patterns.

Abstract:

:Functional neuroimaging suggests asymmetries of memory encoding and retrieval in the prefrontal lobes, but different hypotheses have been presented concerning the nature of prefrontal hemispheric specialization. We studied an associative memory task involving pairs of Kanji (Chinese) pictographs and unfamiliar abstract patterns. Subjects were ten Japanese adults fluent in Kanji, so only the abstract patterns represented novel material. During encoding, transcranial magnetic stimulation (TMS) was applied over the left and right dorsolateral prefrontal cortex (DLPFC). A significant (P<0.05) reduction in subsequent recall of new associations was seen only with TMS over the right DLPFC. This result suggests that the right DLPFC contributes to encoding of visual-object associations, and is consistent with a material-specific rather than a process-specific model of mnemonic function in DLPFC.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Epstein CM,Sekino M,Yamaguchi K,Kamiya S,Ueno S

doi

10.1016/s0304-3940(01)02573-3

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

5-8

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

S0304394001025733

journal_volume

320

pub_type

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