Abstract:
:Functional neuroimaging suggests asymmetries of memory encoding and retrieval in the prefrontal lobes, but different hypotheses have been presented concerning the nature of prefrontal hemispheric specialization. We studied an associative memory task involving pairs of Kanji (Chinese) pictographs and unfamiliar abstract patterns. Subjects were ten Japanese adults fluent in Kanji, so only the abstract patterns represented novel material. During encoding, transcranial magnetic stimulation (TMS) was applied over the left and right dorsolateral prefrontal cortex (DLPFC). A significant (P<0.05) reduction in subsequent recall of new associations was seen only with TMS over the right DLPFC. This result suggests that the right DLPFC contributes to encoding of visual-object associations, and is consistent with a material-specific rather than a process-specific model of mnemonic function in DLPFC.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Epstein CM,Sekino M,Yamaguchi K,Kamiya S,Ueno Sdoi
10.1016/s0304-3940(01)02573-3keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
5-8issue
1-2eissn
0304-3940issn
1872-7972pii
S0304394001025733journal_volume
320pub_type
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