Changes in extracellular amino acid neurotransmitters produced by focal cerebral ischemia.

abstract：:The levels of immunoreactive Leu-enkephalin (ir-Leu-Enk) were measured in acid extract of hearts and lungs of adult normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Heart contents in ir-Leu-Enk were significantly higher in SHR rats (2.67 pmol/g) than in WKY rats (1.5 pmol/g). However, no sign...

journal_title：Neuroscience letters

authors： Dumont M,Lemaire S

更新日期：1988-11-22 00:00:00

abstract：:Odor-induced oscillatory signals have been reported in odor discrimination in various insects. To understand dynamic olfactory coding in the first order olfactory center, the antennal lobe, localization of oscillatory signals was investigated using an optical recording technique with a voltage-sensitive dye. We presen...

journal_title：Neuroscience letters

authors： Okada K,Kanzaki R

更新日期：2001-12-28 00:00:00

abstract：:Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects various cultured neurons against apoptotic stimuli. To investigate whether PEDF acts not only on neurons, but also glial cells, we analyzed the effects of recombinant human PEDF (rhPEDF) on cytokine mRNA levels, t...

journal_title：Neuroscience letters

authors： Sanagi T,Yabe T,Yamada H

更新日期：2005-05-20 00:00:00

abstract：:Recent studies have shown that aging, psychiatric and neurologic diseases, and dopaminergic blockade all result in altered brain network efficiency. We investigated the efficiency of human brain functional networks as measured by fMRI in individuals with idiopathic Parkinson's disease (N=14) compared to healthy age-ma...

journal_title：Neuroscience letters

authors： Skidmore F,Korenkevych D,Liu Y,He G,Bullmore E,Pardalos PM

更新日期：2011-07-15 00:00:00

abstract：:We raised polyclonal antibodies against the C-terminal peptides of protein kinase C (PkC) subspecies alpha, beta 1, beta 2, gamma, delta, epsilon, and zeta and checked their specificity against brain extracts using Western immunoblot analysis. With equal amounts of protein applied to gels PkC subspecies beta 1, delta,...

journal_title：Neuroscience letters

authors： Gott AL,Mallon BS,Paton A,Groome N,Rumsby MG

更新日期：1994-04-25 00:00:00

abstract：:By the use of the peroxidase--antiperoxidase (PAP) technique in the sinus node of several mammalian species, vasoactive intestinal polypeptide (VIP), neurotensin (NT) and substance P (SP) immunoreactive structures were detected. VIP and NT as well as SP immunoreactive fibers were found in close association to the vasc...

journal_title：Neuroscience letters

authors： Weihe E,Reinecke M

更新日期：1981-11-04 00:00:00

abstract：:Pontine parabrachial neurons have been suggested to play a regulatory role in both respiratory and sleep cycle control. Encouraged by the finding that microinjections of the cholinergic agonist carbachol into the medial pontine reticular formation (mPRF) of the cat produced respiratory changes paralleling those observ...

journal_title：Neuroscience letters

authors： Gilbert KA,Lydic R

更新日期：1990-12-11 00:00:00

abstract：:In mammals, methyl-CpG binding proteins play a significant role in the control of gene expression through their association with chromatin-remodeling complexes. Mutations in the gene coding for methyl-CpG-binding protein 2 (MECP2) cause Rett syndrome and have also been reported in a number of X-linked mental retardati...

journal_title：Neuroscience letters

authors： dos Santos JM,Abdalla CB,Campos M Jr,Santos-Rebouças CB,Pimentel MM

更新日期：2005-04-29 00:00:00

abstract：:We previously demonstrated the preventive effect of insulin-like growth factor 1 (IGF-1) on steroid myopathy in rats. However, the mechanism by which IGF-1 inhibits steroid myopathy remains unclear. Recent studies have revealed that glutamine synthetase (GS) is induced by glucocorticoid and may be related to the devel...

journal_title：Neuroscience letters

authors： Kimura K,Kanda F,Okuda S,Chihara K

更新日期：2001-04-20 00:00:00

abstract：:Recently, we reported that voluntary resistance wheel running with a resistance of 30% of body weight (RWR), which produces shorter distances but higher work levels, enhances spatial memory associated with hippocampal brain-derived neurotrophic factor (BDNF) signaling compared to wheel running without a load (WR) [17]...

journal_title：Neuroscience letters

authors： Lee MC,Inoue K,Okamoto M,Liu YF,Matsui T,Yook JS,Soya H

更新日期：2013-03-14 00:00:00

abstract：:Using antibodies to somatostatin in combination with the avidin-biotin immunohistochemical method, the laminar distribution and morphology of somatostatin-like (SOM-L) immunoreactive cells have been studied in the hippocampal formation of the rat. SOM-L positive cells are present throughout the longitudinal axis of th...

journal_title：Neuroscience letters

authors： Köhler C,Chan-Palay V

更新日期：1982-12-31 00:00:00

abstract：:Age-related impairment of learning and memory is a common phenomenon in humans and animals, yet the underlying mechanism remains unclear. We hypothesize that a small ubiquitin-related modifier (Sumo) might correlate with age-related loss of learning and memory. To test this hypothesis, the present study evaluated age-...

journal_title：Neuroscience letters

authors： Yang QG,Wang F,Zhang Q,Xu WR,Chen YP,Chen GH

更新日期：2012-06-19 00:00:00

abstract：:The formation of the beta pleated configuration of the amyloid peptide fragment 25-35 in aqueous solution, has been studied using thioflavin-T fluorescence as an indicator of such folding. Both phosphate and adenosine triphosphate (ATP) enhance the formation of aggregated beta-sheets. This phosphate-induced aggregatio...

journal_title：Neuroscience letters

authors： Bondy SC,Truong A

更新日期：1999-05-21 00:00:00

abstract：:Most of the phasically occurring periods of rapid eye movements (REMs) of active sleep are accompanied by enhanced suppression of somatomotor activity; however, during some of the REM episodes there are muscular twitches and jerks. The membrane potential changes underlying these motor processes were examined by record...

journal_title：Neuroscience letters

authors： Chase MH,Morales FR

更新日期：1982-12-30 00:00:00

abstract：:Kynurenic acid (KYNA), a neuroactive metabolite of tryptophan that acts on different receptors (e.g. those of N-methyl-D-aspartate (NMDA) and presynaptic α7 nicotinic acetylcholine (nACh)), exerts fundamentally antiglutamatergic effects. In view of its antiglutamatergic properties, an elevation of the KYNA level withi...

journal_title：Neuroscience letters

authors： Demeter I,Nagy K,Farkas T,Kis Z,Kocsis K,Knapp L,Gellert L,Fülöp F,Vecsei L,Toldi J

更新日期：2013-10-11 00:00:00

abstract：:Changes in extracellular Ca2+ concentration ([Ca2+]e) evoked by transmitters and transmitter agonists, respectively, and by elevation of bath K+ concentration were recorded in isolated segmental ganglia of the leech Hirudo medicinalis using Ca(2+)-selective microelectrodes. A 1-min bath application of kainate (10 micr...

journal_title：Neuroscience letters

authors： Lohr C,Rose CR,Deitmer JW

更新日期：1996-02-16 00:00:00

abstract：:Using inside-out configuration of patch clamp techniques, actin cytoskeleton modulation of large conductance calcium-activated potassium (BK(Ca)) channels was studied in hippocampal CA1 pyramidal neurons from adult rat. Disruption of actin filament after brief treatment with cytochalasin D (CD) markedly decreased acti...

journal_title：Neuroscience letters

authors： Huang H,Rao Y,Sun P,Gong LW

更新日期：2002-10-31 00:00:00

abstract：:The chitinase 3-like 1 (CHI3L1) gene, a cellular survival factor against several environmental and psychosocial stresses, has been sown to be more highly expressed in the hippocampus and prefrontal cortex of patients with schizophrenia than unaffected individuals. We recently reported a significant association between...

journal_title：Neuroscience letters

authors： Yamamori H,Hashimoto R,Ohi K,Yasuda Y,Fukumoto M,Kasahara E,Sekiyama A,Umeda-Yano S,Okada T,Iwase M,Kazui H,Ito A,Takeda M

更新日期：2012-04-04 00:00:00

abstract：:A neurogenic contribution to joint inflammation has been demonstrated in rat adjuvant arthritis, however as inflammatory mechanisms vary between species it is unclear whether these observations can be applied more generally. The aim of this study was to assess the neurogenic contribution to cellular infiltration and o...

journal_title：Neuroscience letters

authors： Hood VC,Cruwys SC,Urban L,Kidd BL

更新日期：2001-02-23 00:00:00

abstract：:Transverse sections of the monkey cervical spinal cord from a previous study (Jenny and Inukai, 1983) were reanalyzed using Neurolucida to create a three-dimensional display of extensor digitorum communis (EDC) motoneurons and proximal dendrites that had been labeled with horse radish peroxidase (HRP). The EDC motoneu...

journal_title：Neuroscience letters

authors： Jenny AB,Cheney PD,Jenny AK

更新日期：2018-05-14 00:00:00

abstract：:The study examined whether the generation of the forward propulsive force (PF) during gait initiation resulted mainly from the electromyogram activity of stance ankle plantar flexor muscles (APF) which 'push' on the ground as is generally claimed in the literature. Six unilateral above-knee amputees performed a specif...

journal_title：Neuroscience letters

authors： Michel V,Do MC

更新日期：2002-06-07 00:00:00

abstract：:The present study was designed to determine potential associations between the brain damage induced by hypoxic-ischemic (HI) insult and spatial learning impairment in an eight-arm radial maze task. We first determined the pathological outcomes after 2, 5, 9, and 17 weeks of recovery following the HI insult. The result...

journal_title：Neuroscience letters

authors： Mishima K,Ikeda T,Aoo N,Takai N,Takahashi S,Egashira N,Ikenoue T,Iwasaki K,Fujiwara M

更新日期：2005-03-16 00:00:00

abstract：OBJECT:Much evidence has demonstrated that stress and tumor interact, but the mechanisms are poorly understood. The purpose of this study is to discuss the effect of unpredictable chronic mild stress (CMS) upon the behavior of Walker 256 tumor-bearing rats and its mechanism. METHODS:Observe the effects of CMS on the s...

journal_title：Neuroscience letters

authors： Xiu LJ,Lin HM,Wei PK

更新日期：2010-03-31 00:00:00

abstract：:NMDA and non-NMDA receptor-mediated components of excitatory post-synaptic current (EPSC) were studied by in situ whole-cell voltage-clamp recordings in the CA1 field of rat hippocampus. We found that the amplitudes ratio of the NMDA to the non-NMDA components can be strongly increased by blocking A1 adenosine recepto...

journal_title：Neuroscience letters

authors： Klishin A,Lozovaya N,Krishtal O

更新日期：1994-09-26 00:00:00

abstract：:Emotional processing in coma remains an open question. Skin conductance responses to emotional and neutral auditory stimuli were recorded in 13 low-responsive patients (12 of whom were in coma). A differential response between emotional and neutral stimuli was found, which significantly correlated with the Glasgow Com...

journal_title：Neuroscience letters

authors： Daltrozzo J,Wioland N,Mutschler V,Lutun P,Calon B,Meyer A,Jaeger A,Pottecher T,Kotchoubey B

更新日期：2010-05-07 00:00:00

abstract：:Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of domestic and wild cervids in North America. To address possible prevention regimens for CWD, we have used a mouse model system and the Rocky Mountain Laboratory (RML) mouse-adapted scrapie prion strain to screen efficacy of potential v...

journal_title：Neuroscience letters

authors： Pilon J,Loiacono C,Okeson D,Lund S,Vercauteren K,Rhyan J,Miller L

更新日期：2007-12-18 00:00:00

abstract：:Two types of cone horizontal cells were identified morphologically in the retina of a trichromatic fish by fluorescent labelling with Lucifer Yellow and confocal laser scanning microscopy. H1 cells are located adjacent to the outer plexiform layer, have large somata, small dendritic fields, and contact all cone types....

journal_title：Neuroscience letters

authors： Braun SC,Kröger RH,Wagner HJ

更新日期：1997-10-17 00:00:00

abstract：:Tris-HCl is the most commonly used buffer in studies of radioligand binding to sigma receptors, with concentrations as high as 50 or 100 mM often used. We report here that these concentrations of Tris substantially inhibit (+)-[3H]SKF-10,047 binding to sigma receptors. The well-established inhibitory effect of Tris-HC...

journal_title：Neuroscience letters

authors： McCann DJ,Su TP

更新日期：1992-07-20 00:00:00

abstract：:To test the hypothesis that the expression of specific proteins on peripheral terminals of primary afferents can be attenuated by intrathecal administration of antisense oligodeoxynucleotides (ODNs), we administered ODNs antisense to the mu-opioid receptor to male Sprague-Dawley rats via chronically implanted intrathe...

journal_title：Neuroscience letters

authors： Khasar SG,Gold MS,Dastmalchi S,Levine JD

更新日期：1996-10-25 00:00:00

abstract：:Early craniectomy has shown to reduce infarction size in experimental large MCA infarction probably due to improved leptomeningeal perfusion. Based on the hypothesis that craniectomy may also be beneficial in smaller MCA infarction we evaluated the effects of craniectomy on infarction size in small thromboembolic cere...

journal_title：Neuroscience letters

authors： Engelhorn T,Heiland S,Schabitz WR,Schwab S,Busch E,Forsting M,Doerfler A

更新日期：2004-11-11 00:00:00