Abstract:
:NMDA and non-NMDA receptor-mediated components of excitatory post-synaptic current (EPSC) were studied by in situ whole-cell voltage-clamp recordings in the CA1 field of rat hippocampus. We found that the amplitudes ratio of the NMDA to the non-NMDA components can be strongly increased by blocking A1 adenosine receptors. The necessary conditions for this effect are both, increased Ca2+ and lowered Mg2+ in the external medium. The so achieved increase in the NMDA/non-NMDA ratio of EPSC components is irreversible and no longer depends on the activity of A1 adenosine receptors.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Klishin A,Lozovaya N,Krishtal Odoi
10.1016/0304-3940(94)90952-0subject
Has Abstractpub_date
1994-09-26 00:00:00pages
132-6issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(94)90952-0journal_volume
179pub_type
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