Persistently enhanced ratio of NMDA and non-NMDA components of rat hippocampal EPSC after block of A1 adenosine receptors at increased [Ca2+]o/[Mg2+]o.

Abstract:

:NMDA and non-NMDA receptor-mediated components of excitatory post-synaptic current (EPSC) were studied by in situ whole-cell voltage-clamp recordings in the CA1 field of rat hippocampus. We found that the amplitudes ratio of the NMDA to the non-NMDA components can be strongly increased by blocking A1 adenosine receptors. The necessary conditions for this effect are both, increased Ca2+ and lowered Mg2+ in the external medium. The so achieved increase in the NMDA/non-NMDA ratio of EPSC components is irreversible and no longer depends on the activity of A1 adenosine receptors.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Klishin A,Lozovaya N,Krishtal O

doi

10.1016/0304-3940(94)90952-0

subject

Has Abstract

pub_date

1994-09-26 00:00:00

pages

132-6

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(94)90952-0

journal_volume

179

pub_type

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