Caffeine down-regulates beta adrenoreceptors in rat forebrain.

abstract：:The distribution of mRNA coding for a pituitary thyrotropin releasing-hormone (TRH) receptor was examined on sections of spinal cord and lower brainstem of rat using in situ hybridization. Hybridization signals were observed over large neurons in the ventral horn in cervical, thoracic, and lumbar segments of spinal co...

journal_title：Neuroscience letters

authors： Wu W,Elde R,Wessendorf MW,Hökfelt T

更新日期：1992-08-17 00:00:00

abstract：:Vlgr1 (very large G-protein coupled receptor 1) knockout mice against hybrid backgrounds of the 129/Ola and C57BL/6 mouse strains show hearing deficit and high susceptibility to audiogenic seizures. The present study examined how hearing impairment and susceptibility to audiogenic seizures in Vlgr1-deficient mice chan...

journal_title：Neuroscience letters

authors： Yagi H,Noguchi Y,Kitamura K,Sato M

更新日期：2009-09-18 00:00:00

abstract：:Noradrenaline enhanced in a concentration-dependent way the basal release of endogenous GABA from superfused rat hippocampus synaptosomes. The alpha 2-adrenoceptor antagonist yohimbine prevented the releasing effect of noradrenaline while the alpha 1-adrenoceptor antagonist prazosin was ineffective. It is concluded th...

journal_title：Neuroscience letters

authors： Pittaluga A,Raiteri M

更新日期：1987-05-19 00:00:00

abstract：:Tryptophan hydroxylase 2 (TPH2) is a rate-limiting enzyme of neuronal serotonin biosynthesis. Recently, two single nucleotide polymorphisms (SNPs) at the exon 11 coding region that resulted in amino acid substitutions in the C-terminal domain have been reported to affect enzyme activity in humans and mice. We determin...

journal_title：Neuroscience letters

authors： Hong KW,Sugawara Y,Hasegawa H,Hayasaka I,Hashimoto R,Ito S,Inoue-Murayama M

更新日期：2007-02-02 00:00:00

abstract：:The present study is designed to screen the effect of syringin, an active principle purified from the rhizome and root parts of Eleutherococcus senticosus (Araliaceae), on the plasma glucose and investigate the possible mechanisms. Plasma glucose decreased in a dose-dependent manner 60 min after intravenous injection ...

journal_title：Neuroscience letters

authors： Liu KY,Wu YC,Liu IM,Yu WC,Cheng JT

更新日期：2008-03-28 00:00:00

abstract：:Almost all mechanoreceptive neurons in the cortical taste area (CTA) of the rat had receptive fields (RFs) in the oral cavity, except for a few neurons at the border with the primary somatosensory area that had RFs on the contralateral rhinarium or upper lip. About one-third of the mechanoreceptive neurons with RFs in...

journal_title：Neuroscience letters

authors： Ogawa H,Wang XD

更新日期：2002-04-05 00:00:00

abstract：:Identified in 1993, APOE4 is the greatest genetic risk factor for Alzheimer's disease (AD), increasing risk up to 15-fold compared to the common variant APOE3. Since the mid 1990's, transgenic (Tg) mice have been developed to model AD pathology and progression, primarily via expression of the familial AD (FAD) mutatio...

journal_title：Neuroscience letters

authors： Balu D,Karstens AJ,Loukenas E,Maldonado Weng J,York JM,Valencia-Olvera AC,LaDu MJ

更新日期：2019-08-10 00:00:00

abstract：:The characteristics of long-term potentiation (LTP) in the hippocampus of rats prenatally exposed to ethanol and treated postnatally with nootropic compounds L-pyroglutamyl-D-alanine-amide (L-pGlu-D-AlaNH2, PGA) or piracetam were studied using in vitro slice preparations. LTP was induced in the CA1 region by the ortho...

journal_title：Neuroscience letters

authors： Chepkova AN,Doreulee NV,Trofimov SS,Gudasheva TA,Ostrovskaya RU,Skrebitsky VG

更新日期：1995-03-31 00:00:00

abstract：:Facilitation of synaptic connections between sensory neurons and motor neurons mediating the tail-withdrawal reflex in Aplysia is produced by sensitizing stimuli. These effects can be mimicked by perfusing the pleural and pedal ganglia of a semi-intact preparation with serotonin (5-HT). In addition to the synaptic fac...

journal_title：Neuroscience letters

authors： Walsh JP,Byrne JH

更新日期：1984-11-23 00:00:00

abstract：:Antibodies directed against a glutamate transporter (GLT-1) purified from rat brain were applied to cryostat sections of rat and macaque monkey retinae. In the brain, GLT-1 expression is found mainly in astrocytes, and therefore it has been suggested that GLT-1 may be a glutamate transporter specific to glial cells. H...

journal_title：Neuroscience letters

authors： Rauen T,Kanner BI

更新日期：1994-03-14 00:00:00

abstract：:A trait locus for electroencephalographic photoparoxysmal response (PPR) has been mapped to the chromosomal region 6p21 near a susceptibility locus for juvenile myoclonic epilepsy (JME). Linkage disequilibrium mapping revealed strong associations between JME and polymorphisms of the gene encoding the bromodomain-conta...

journal_title：Neuroscience letters

authors： Lorenz S,Taylor KP,Gehrmann A,Becker T,Muhle H,Gresch M,Tauer U,Sander T,Stephani U

更新日期：2006-05-29 00:00:00

abstract：:Bereitschaftspotentials (BPs) preceding muscle relaxation and contraction were compared by using subdural electrodes which were implanted onto the right medial frontal surface in two patients with supplementary motor area (SMA) seizure. The applied movement paradigm (muscle relaxation and contraction tasks) was comple...

journal_title：Neuroscience letters

authors： Yazawa S,Ikeda A,Kunieda T,Mima T,Nagamine T,Ohara S,Terada K,Taki W,Kimura J,Shibasaki H

更新日期：1998-03-20 00:00:00

abstract：:The morphology of somatosensory evoked fields (SEF) following electrical separate stimulation of left and right median nerve in 22 healthy volunteers was explored. The analysis of morphological properties of individual SEFs has been performed, in order to quantify an inter-hemispheric correlation coefficient. Despite ...

journal_title：Neuroscience letters

authors： Tecchio F,Pasqualetti P,Pizzella V,Romani G,Rossini PM

更新日期：2000-06-30 00:00:00

abstract：:The AMPA receptor subunit GluR2 is downregulated in neurons following a wide range of neurological insults. Here we report that suppression of GluR2 gene promoter activity is associated with kainate (KA)-induced downregulation of GluR2 subunit levels in primary cultured cortical neurons. RT-PCR and Northern blotting s...

journal_title：Neuroscience letters

authors： Jia YH,Zhu X,Li SY,Ni JH,Jia HT

更新日期：2006-07-31 00:00:00

abstract：:Chronic stress is well known to exacerbate pain. We tested the hypothesis that neonatal handling, which induces resilience to the negative impact of stress by increasing the quality and quantity of maternal care, attenuates the mechanical hyperalgesia produced by water-avoidance stress in the adult rat. Neonatal male ...

journal_title：Neuroscience letters

authors： Alvarez P,Levine JD,Green PG

更新日期：2015-03-30 00:00:00

abstract：:Intracellular and extracellular recordings were obtained from layers II-III of slices of adult rat neocortex maintained in vitro. Excitatory postsynaptic potentials (EPSPs) and epileptiform discharges (paroxysmal depolarizing shifts, PDSs) were evoked in the presence of bicuculline methiodide. Responses were monitored...

journal_title：Neuroscience letters

authors： Burke JP,Hablitz JJ

更新日期：1994-06-06 00:00:00

abstract：:Recent studies have described the role of various regions of the neural cell adhesion molecule (NCAM) in cell-cell interactions. Monoclonal antibodies (L2/HNK-1) directed against a sulfated, glucuronic acid-containing, N-linked carbohydrate epitope have also been shown to inhibit NCAM-mediated neural cell adhesion. In...

journal_title：Neuroscience letters

authors： Cole GJ,Schachner M,Fliesler SJ

更新日期：1988-11-11 00:00:00

abstract：:The neurotoxicity of the glutamate receptor agonists N-methyl-D-aspartate (NMDA), (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), and kainate was quantitatively assessed in murine spinal cord and cortical cultures prepared under identical conditions. Compared with cortical neurons, spinal neuron...

journal_title：Neuroscience letters

authors： Regan RF

更新日期：1996-07-26 00:00:00

abstract：:Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in the human diet. Recently, it is demonstrated to have potent antinociceptive effect. However, little is understood about the mechanism underlying CGA analgesia. Here, we have found that CGA can exert an inhibitory effect on the functional activi...

journal_title：Neuroscience letters

authors： Qu ZW,Liu TT,Qiu CY,Li JD,Hu WP

更新日期：2014-05-01 00:00:00

abstract：:Recent evidence demonstrated that lesion-induced central nervous system changes are at least partly mediated by the action of the gaseous transmitter nitric oxide (NO). We investigated the hypothesis that the frequency of peripheral C-fibre stimulation determines the number of neurones in the dorsal horn that can be v...

journal_title：Neuroscience letters

authors： Hoheisel U,Kaske A,Reinert A,Mense S

更新日期：1997-05-23 00:00:00

abstract：:Evidence suggests that nitric oxide (NO) may mediate, at least in part, excitotoxic effects of excessive N-methyl-D-aspartate (NMDA) receptor activation both in vivo and in vitro. In the present experiments, NMDA-induced excitotoxicity has been studied in CHP100 neuroblastoma cell cultures. Application of NMDA (0.25-1...

journal_title：Neuroscience letters

authors： Corasaniti MT,Tartaglia RL,Melino G,Nisticò G,Finazzi-Agrò A

更新日期：1992-12-07 00:00:00

abstract：:Cholecystokinin (CCK) is suggested to be involved, e.g. in the central nervous modulation of food intake, possibly by acting within specific hypothalamic nuclei. Perinatal overnutrition predisposes to permanent obesity and hyperphagia, while underlying mechanisms are unclear. By reducing the litter size from the 3rd t...

journal_title：Neuroscience letters

authors： Plagemann A,Rake A,Harder T,Melchior K,Rohde W,Dörner G

更新日期：1998-12-11 00:00:00

abstract：:A hybridoma cell line secreting a monoclonal antibody against catalytic subunits of acetylcholinesterase in the electric organ of Narke japonica has been obtained by using a mouse immunized with the nerve terminal membranes prepared from the electric organ of Narke japonica. This monoclonal antibody (Nj-501) reacted w...

journal_title：Neuroscience letters

authors： Abe T,Sakai M,Saisu H

更新日期：1983-07-15 00:00:00

abstract：:myo-Inositol monophosphatase (E.C.3.1.3.25) catalyzes the hydrolysis of myo-inositol 1-phosphate in the presence of Mg2+ at a physiologic pH to form free myo-inositol, maintaining a supply that represents the precursor for inositol phospholipid second messenger signaling systems. In the present study the activity and ...

journal_title：Neuroscience letters

authors： Shimohama S,Tanino H,Sumida Y,Tsuda J,Fujimoto S

更新日期：1998-04-10 00:00:00

abstract：:Acetate is the primary product of ethanol catabolism and can accumulate in the blood at concentrations of up to 2 mM following ethanol consumption. It has been suggested that some of the pharmacological actions of ethanol are mediated via acetate, which can lead indirectly to the release of endogenous adenosine. In th...

journal_title：Neuroscience letters

authors： Brundege JM,Dunwiddie TV

更新日期：1995-02-17 00:00:00

abstract：:To demonstrate the preference of lactate over glucose as an energy substrate in normal brain tissue under normoxic condition, the dynamic changes in glucose uptake by lactate loading were investigated in living rat brain slices using a positron autoradiography technique. Fresh rat brain slices were incubated with [18F...

journal_title：Neuroscience letters

authors： Murata T,Waki A,Omata N,Fujibayashi Y,Sadato N,Yano R,Yoshimoto M,Isaki K,Yonekura Y

更新日期：1998-06-19 00:00:00

abstract：:Stem cells are used to generate differentiated somatic cells including neuronal cells. Synthesis and release of acetylcholine, a neurotransmitter and widely expressed signaling molecule, were investigated in the murine embryonic stem cell line CGR8 during early differentiation, i.e. in the presence of leukemia inhibit...

journal_title：Neuroscience letters

authors： Wessler I,Michel-Schmidt R,Schmidt H,Kaltwasser S,Unger R,Kirkpatrick CJ

更新日期：2013-06-28 00:00:00

abstract：:The present study confirmed histopathologically the suggestion that pulmonary edema may underlie the fulminant death following microinjection of kainic acid into many medullary sites in rats anesthetized with pentobarbital sodium. We also observed a sustained elevation in systemic arterial pressure, cardiac contractil...

journal_title：Neuroscience letters

authors： Chan SH,Chong AP,Ong BT,Chong OK,Lim HC

更新日期：1985-12-18 00:00:00

abstract：:Alzheimer' disease is a neurodegenerative disorder characterized by the misfolding and aggregation of amyloid β (Aβ). This process is influenced through supply of cholesterol via apolipoproteins to neurons. In the present study, we used the transgenic Caenorhabditis elegans strain CL2006, which expresses Aβ1-42 under ...

journal_title：Neuroscience letters

authors： Regitz C,Wenzel U

更新日期：2014-07-25 00:00:00

abstract：:A FORTRAN computer program is described which enables solution of a set of partial differential equations describing synaptic transmission, including neurotransmitter diffusion, binding to receptors on the postsynaptic membrane with subsequent formation of open ion-conducting channels, and hydrolysis. Integration is p...

journal_title：Neuroscience letters

authors： Madsen BW,Edeson RO,Lam HS,Milne RK

更新日期：1984-07-13 00:00:00