Effects of centrally administered atrial natriuretic polypeptide on sympathetic nerve activity and blood flow to the kidney in conscious rats.

Abstract:

:Effects of intracerebroventricular (i.c.v.) administration of atrial natriuretic polypeptide (ANP) on renal sympathetic nerve activity (RSNA) and renal blood flow (RBF) were examined in conscious rats. Administration of ANP had no appreciable effects on baseline RSNA and RBF. The pressor response induced by i.c.v. angiotensin II (AII) was attenuated by prior i.c.v. administration of ANP but no significant effect of ANP was observed on the AII-induced bradycardia and inhibition of RSNA. The result shows that centrally administered ANP has little effect on basal RSNA and RBF but it antagonizes the pressor response caused by AII without affecting induced changes in heart rate and RSNA.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Kannan H,Ueta Y,Nakamura T,Yamashita H,Hayashida Y

doi

10.1016/0304-3940(90)90397-r

subject

Has Abstract

pub_date

1990-08-14 00:00:00

pages

123-9

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(90)90397-R

journal_volume

116

pub_type

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