Abstract:
:trk receptors are downregulated in both dorsal root ganglion (DRG) and spinal motoneurons of aged rats with behavioral sensorimotor deficits. Here we provide evidence, using reverse transcription-polymerase chain reaction (RT-PCR), of decreased levels of neurotrophin (nerve growth factor, NGF; brain-derived neurotrophic factor, BDNF; neurotrophin-3, NT-3; and neurotrophin-4, NT-4) mRNAs in target muscles. Moreover, the degree of neurotrophin mRNA decrease in target muscles seems to co-vary with the extent of sensorimotor disturbances. In contrast, the peripheral nerve of aged rats showed a reciprocal regulation of neurotrophins, with increased levels of NGF, BDNF, and NT-4 mRNAs. Taken together, evidence suggest an aging-related attenuation of neurotrophin signaling between target tissues, on one hand, and DRG and motoneurons, on the other, and, furthermore, that target-derived neurotrophins regulate the expression levels of trk mRNAs in both DRG and motoneurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ming Y,Bergman E,Edström E,Ulfhake Bdoi
10.1016/s0304-3940(99)00655-2keywords:
subject
Has Abstractpub_date
1999-10-08 00:00:00pages
187-90issue
3eissn
0304-3940issn
1872-7972pii
S0304394099006552journal_volume
273pub_type
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