Melatonin supplementation delays the decline of adult hippocampal neurogenesis during normal aging of mice.

Abstract:

:Melatonin modulates adult hippocampal neurogenesis in adult mice. Also, plasma melatonin levels and new neuron formation decline during aging probably causing cognitive alterations. In this study, we analyzed the impact of exogenous supplementation with melatonin in three key events of hippocampal neurogenesis during normal aging of mice. The analysis was performed in rodents treated with melatonin during 3, 6, 9 or 12 months. We found an increase in cell proliferation in the dentate gyrus of the hippocampus after 3, 6 and 9 months of treatment (>90%). Additionally, exogenous melatonin promoted survival of new cells in the dentate gyrus (>50%). Moreover, melatonin increased the number of doublecortin-labeled cells after 6 and 9 months of treatment (>150%). In contrast, melatonin administered during 12 months did not induce changes in hippocampal neurogenesis. Our results indicate that melatonin also modulates the neurogenic process in the hippocampus during normal aging of mice. Together, the data support melatonin as one of the positive endogenous regulators of neurogenesis during aging.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Ramírez-Rodríguez G,Vega-Rivera NM,Benítez-King G,Castro-García M,Ortíz-López L

doi

10.1016/j.neulet.2012.09.045

subject

Has Abstract

pub_date

2012-11-14 00:00:00

pages

53-8

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(12)01291-8

journal_volume

530

pub_type

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