Abstract:
:Melatonin modulates adult hippocampal neurogenesis in adult mice. Also, plasma melatonin levels and new neuron formation decline during aging probably causing cognitive alterations. In this study, we analyzed the impact of exogenous supplementation with melatonin in three key events of hippocampal neurogenesis during normal aging of mice. The analysis was performed in rodents treated with melatonin during 3, 6, 9 or 12 months. We found an increase in cell proliferation in the dentate gyrus of the hippocampus after 3, 6 and 9 months of treatment (>90%). Additionally, exogenous melatonin promoted survival of new cells in the dentate gyrus (>50%). Moreover, melatonin increased the number of doublecortin-labeled cells after 6 and 9 months of treatment (>150%). In contrast, melatonin administered during 12 months did not induce changes in hippocampal neurogenesis. Our results indicate that melatonin also modulates the neurogenic process in the hippocampus during normal aging of mice. Together, the data support melatonin as one of the positive endogenous regulators of neurogenesis during aging.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ramírez-Rodríguez G,Vega-Rivera NM,Benítez-King G,Castro-García M,Ortíz-López Ldoi
10.1016/j.neulet.2012.09.045subject
Has Abstractpub_date
2012-11-14 00:00:00pages
53-8issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(12)01291-8journal_volume
530pub_type
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