Efficient in vitro amplification of a mouse-adapted scrapie prion protein.

abstract：:A valinomycin-based membrane phase for microelectrodes with relatively low electrical membrane resistances is described. Microelectrodes with tip diameters of about 1 micron exhibit resistances of about 10(10) omega. Extremely high K+ selectivities are obtained, e.g. a rejection of Na+ by a factor of 5000 and of acety...

journal_title：Neuroscience letters

authors： Ammann D,Chao PS,Simon W

更新日期：1987-02-24 00:00:00

abstract：:Repeated or sustained exposure to opioids can not only induce analgesia but also long lasting enhancements in pain sensitivity, a phenomenon reported clinically and in animals. In rats, opioid-induced abnormal pain can be readily measured following continued delivery of morphine and the recruitment of descending facil...

journal_title：Neuroscience letters

authors： Suzuki R,Porreca F,Dickenson AH

更新日期：2006-10-23 00:00:00

abstract：:Employing double anterograde axonal tracing in combination with intracortical microstimulation, we examined the distribution patterns of corticosubthalamic inputs from forelimb representations of the dorsal (PMd) and ventral (PMv) divisions of the premotor cortex in the macaque monkey. The inputs from the PMd and PMv ...

journal_title：Neuroscience letters

authors： Nambu A,Tokuno H,Inase M,Takada M

更新日期：1997-12-12 00:00:00

abstract：:Intellectual disability (ID) is one of the most prevalent chronic developmental brain disorders or phenotype of syndromic ID, affecting nearly 1-2% of the general population worldwide. Over recent decades, tremendous effort and high-throughput platforms have been devised to explore the complex heterogeneity, numerous ...

journal_title：Neuroscience letters

authors： Chen C,Chen D,Xue H,Liu X,Zhang T,Tang S,Li W,Xu X

更新日期：2018-10-15 00:00:00

abstract：:Superoxide dismutase 1 (SOD1) aggregates are a histological and biochemical correlate of disease progression in neural tissues from mutant SOD1-linked forms of familial amyotrophic lateral sclerosis (FALS). In the present study, we assayed the monomeric and high molecular weight mutant SOD1 content of nervous, muscle ...

journal_title：Neuroscience letters

authors： Turner BJ,Lopes EC,Cheema SS

更新日期：2003-10-23 00:00:00

abstract：:Alzheimer disease (AD) is the most common type of dementia, and is currently incurable. The efficacy of existing treatments for AD such as acetylcholinesterase inhibitors is limited to symptom improvement. Research on disease-modifying therapies (DMTs) has conventionally focused on amelioration of CNS pathogenesis. Tw...

journal_title：Neuroscience letters

authors： Shozawa H,Oguchi T,Tsuji M,Yano S,Kiuchi Y,Ono K

更新日期：2018-06-11 00:00:00

abstract：:We examined the effects of chronic in vivo antipsychotic drug treatments on G protein function and regulation. Mice were treated with typical antipsychotic haloperidol (6 mg/kg per day) and atypical agent olanzapine (20 mg/kg per day) for 14 days via mini-osmotic pumps. G protein-activated adenylyl cyclase activity in...

journal_title：Neuroscience letters

authors： Kaplan GB,Leite-Morris KA,Keith DJ

更新日期：1999-10-08 00:00:00

abstract：:Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of domestic and wild cervids in North America. To address possible prevention regimens for CWD, we have used a mouse model system and the Rocky Mountain Laboratory (RML) mouse-adapted scrapie prion strain to screen efficacy of potential v...

journal_title：Neuroscience letters

authors： Pilon J,Loiacono C,Okeson D,Lund S,Vercauteren K,Rhyan J,Miller L

更新日期：2007-12-18 00:00:00

abstract：:The effects of bath-applied phorbol esters, protein kinase C (PKC) activators, and sphingosine, a PKC inhibitor, on membrane currents evoked by serotonin were studied in Xenopus oocytes injected with rat brain mRNA. The oscillatory Cl- current in response to bath-applied 50 nM serotonin was significantly depressed by ...

journal_title：Neuroscience letters

authors： Matsumoto M,Barnard EA

更新日期：1994-02-14 00:00:00

abstract：:Genetic polymorphism of human bleomycin hydrolase (hBH) has been reported to be associated with the risk of sporadic Alzheimer's disease (AD). The regional and cellular distribution of mRNA encoding hBH in the brain from controls and patients with AD was examined using in situ hybridization. A hybridization signal, in...

journal_title：Neuroscience letters

authors： Malherbe P,Faull RL,Richards JG

更新日期：2000-03-03 00:00:00

abstract：BACKGROUND/AIM:Depressive disorders are multifactorial diseases, in which cognitive impairment is one of the characteristic feature. One of the molecules that regulate of various cognitive, emotional and behavioural processes is nitric oxide (NO), synthesized from l-arginine by a family of isoformic enzymes known as ni...

journal_title：Neuroscience letters

authors： Talarowska M,Gałecki P,Maes M,Orzechowska A,Chamielec M,Bartosz G,Kowalczyk E

更新日期：2012-02-29 00:00:00

abstract：:Vasoactive intestinal polypeptide (VIP) in the concentration of 1 microM or less markedly and selectively increased the amplitude and duration of the muscarinic slow excitatory postsynaptic potential (EPSP) without appreciably affecting the nicotinic fast EPSP or the non-cholinergic EPSP of guinea pig inferior mesente...

journal_title：Neuroscience letters

authors： Mo N,Dun NJ

更新日期：1984-11-23 00:00:00

abstract：:In previous studies, chronic low-dose methylphenidate (MPH) administration during early development has been shown to increase emotional responding in adulthood. However, most studies employed male subjects, which generally show enhanced fear relative to females in laboratory tests of anxious behaviors. The present st...

journal_title：Neuroscience letters

authors： Bethancourt JA,Vásquez CE,Britton GB

更新日期：2011-05-27 00:00:00

abstract：:The mammalian circadian system contains both central and peripheral oscillators. It was reported that the rhythmic expressions of period homolog 2 (per2) mRNA in peripheral tissues were abolished by the suprachiasmatic nucleus (SCN) lesions. However, there are no reports that ventromedial hypothalamic (VMH) lesions ca...

journal_title：Neuroscience letters

authors： Kiba T,Kintaka Y,Suzuki Y,Ishizuka N,Ishigaki Y,Inoue S

更新日期：2010-03-08 00:00:00

abstract：:As the pre-dementia phase of Alzheimer disease, mild cognitive impairment (MCI) involves the onset and development of cognitive impairments. Opioid receptors play pivotal roles in the regulation of learning and cognition. Our study focused on the association of OPRK1 and OPRM1 methylation with MCI in Xinjiang Uygur an...

journal_title：Neuroscience letters

authors： Liu G,Ji H,Liu J,Xu C,Chang L,Cui W,Ye C,Hu H,Chen Y,Zhou X,Duan S,Wang Q

更新日期：2017-01-01 00:00:00

abstract：:We investigated the mRNA expression of the various complement components in cultured mouse microglia and astrocytes by the reverse transcription and polymerase chain reaction. C1q, C2, C3, and C4 mRNAs were detected in microglial cultures. C3 and C4 mRNAs were found in astrocyte cultures. Microglia showed enhanced exp...

journal_title：Neuroscience letters

authors： Haga S,Aizawa T,Ishii T,Ikeda K

更新日期：1996-10-04 00:00:00

abstract：:Guanosine triphosphate cyclohydrolase 1 (GCH1) is the rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin, a cofactor for aromatic amino acid hydroxylases and nitric oxide synthases. As monoamine neurotransmitters are synthesized by the reactions catalyzed by tyrosine hydroxylase and tryptophan hydroxylas...

journal_title：Neuroscience letters

authors： Yasuda Y,Hashimoto R,Ohi K,Yamamori H,Fujimoto M,Umeda-Yano S,Fujino H,Fukunaga M,Horiguchi M,Takeda M,Ichinose H

更新日期：2014-04-30 00:00:00

abstract：:Gap junction (GJ) coupling between neocortical GABAergic interneurons plays a critical role in the synchronization of activity in cortical networks in physiological and pathophysiological states, e.g., seizures. Past studies have shown that GJ blockers exert anticonvulsant actions in both in vivo and in vitro models o...

journal_title：Neuroscience letters

authors： Yang L,Ling DS

更新日期：2007-04-18 00:00:00

abstract：:Kainic acid (KA) has been largely used as a neurotoxin, and its axon-sparing effect being repeatedly emphasized, on the basis of anatomical and biochemical data. The present study examines this 'axon-sparing' effect from an electrophysiological point of view and demonstrates that lemniscal fibers retain the capacity t...

journal_title：Neuroscience letters

authors： Peschanski M,Briand A,Poingt JP,Guilbaud G

更新日期：1985-08-05 00:00:00

abstract：:Temperature effects on ocular serotonin N-acetyltransferase (NAT) kinetics characteristics from Rana perezi have been studied with respect to tryptamine and serotonin as substrates. Monoamine oxidase (MAO) activity does not interfere in NAT assay at acceptoramine concentrations used in NAT kinetics characterization fr...

journal_title：Neuroscience letters

authors： Alonso-Gómez AL,Alonso-Bedate M,Delgado MJ

更新日期：1993-05-28 00:00:00

abstract：:To investigate the actions of glucocorticoids (GCs) on astrocyte functions, interactions of dexamethasone and immediate early genes (IEGs) were studied in cell cultures of rat cerebral cortical astrocytes. Vasoactive intestinal peptide (VIP) induces rapid c-fos mRNA expression and morphological changes (stellation) in...

journal_title：Neuroscience letters

authors： Hisanaga K,Sagar SM,Koistinaho J,Hicks KJ,Sharp FR

更新日期：1993-06-25 00:00:00

abstract：:We investigated laminin beta1 expression in the hippocampi of patients with intractable epilepsy and explored the role of laminin beta1 in the pathogenesis of this condition. Fluorescence quantitative PCR, immunofluorescence, immunohistochemistry and Western blotting were used to measure laminin beta1 expression in su...

journal_title：Neuroscience letters

authors： Wu Y,Wang XF,Mo XA,Sun HB,Li JM,Zeng Y,Lin T,Yuan J,Xi ZQ,Zhu X,Zheng JO

更新日期：2008-10-10 00:00:00

abstract：:Somatostatin (SRIF) release from rat hypothalamus was investigated in vitro with a perifusion system. Glucagon (1 microM) and high potassium concentrations (56 mM) stimulated SRIF release in a calcium-dependent manner. Pretreatment of the rat with cysteamine (30 mg/100 g body weight, 7 h earlier) significantly reduced...

journal_title：Neuroscience letters

authors： Shimatsu A,Kato Y,Matsushita N,Ohta H,Kabayama Y,Imura H

更新日期：1983-06-30 00:00:00

abstract：:The function of Merkel cells in mechanotransduction has remained controversial Single unit recordings were made from Merkel cell receptors (sinus hair type I, St I) and another slowly adapting mechanoreceptor (sinus hair type II, St II) in isolated rat sinus hairs by applying controlled mechanical displacements to the...

journal_title：Neuroscience letters

authors： Senok SS,Halata Z,Baumann KI

更新日期：1996-08-23 00:00:00

abstract：:Changes in the activity of the autonomic nervous system are good indicators of alterations in physiological phenomena such as the body temperature, blood glucose, blood pressure. Hesperidin, a flavanone known as vitamin P, has been shown to reduce the levels of serum lipids, cholesterol, and blood pressure. However, h...

journal_title：Neuroscience letters

authors： Shen J,Nakamura H,Fujisaki Y,Tanida M,Horii Y,Fuyuki R,Takumi H,Shiraishi K,Kometani T,Nagai K

更新日期：2009-09-11 00:00:00

abstract：:Aging is associated with cognitive deterioration. A recent study showed two polymorphisms (rs505058 in LMNA and rs11622883 near a SERPINA13 gene), identified in a genome-wide association study of late-onset Alzheimer's disease, to be associated with cognitive function (Mini Mental State Examination) in a UK elderly po...

journal_title：Neuroscience letters

authors： Yeh HL,Hou SJ,Yen FC,Hong CJ,Liou YJ,Yang AC,Liu ME,Tsai SJ

更新日期：2011-10-17 00:00:00

abstract：:Harmonically rich sounds have been shown to be processed more efficiently by the human brain compared to single sinusoidal tones. To control for stimulus complexity as a potentially confounding factor, tones and equally complex spectrally rotated sounds, have been used in the present study to investigate the role of t...

journal_title：Neuroscience letters

authors： Christmann CA,Lachmann T,Berti S

更新日期：2014-10-03 00:00:00

abstract：:The mouse model of transcranial permanent occlusion of the middle cerebral artery (tpMCAO) is widely used in stroke research. Here we quantified infarct size using a conventional histological method at several post-ischaemic times, going beyond the commonly analysed period of up to 2 days, following artery occlusion. ...

journal_title：Neuroscience letters

authors： Henrich-Noack P,Baldauf K,Reiser G,Reymann KG

更新日期：2008-02-20 00:00:00

abstract：:Neurotrophic factors regulate neuronal survival and differentiation and control neurite outgrowth by binding to tyrosine kinase receptors, the Trks, and a tumor necrosis factor (TNF) receptor-like molecule, p75 neurotrophin receptor. A proinflammatory cytokine, TNF, also affects survival and apoptotic death in neurona...

journal_title：Neuroscience letters

authors： Furuno T,Nakanishi M

更新日期：2006-01-16 00:00:00

abstract：:Molecular forms of butyrylcholinesterase (BuChE) were studied in microvessels isolated from rat brain, using sedimentation analysis in sucrose gradients. Three forms, G1, G2 and G4, were found with sedimentation coefficients close to 3S, 6S and 9S, respectively. The relative proportion of the 3 forms was 19% for the m...

journal_title：Neuroscience letters

authors： Catalán RE,Martínez AM,Aragonés MD,Hernández F

更新日期：1990-11-27 00:00:00