Differential effects of treatment with typical and atypical antipsychotic drugs on adenylyl cyclase and G proteins.

abstract：:Effects of intracerebroventricular (i.c.v.) administration of atrial natriuretic polypeptide (ANP) on renal sympathetic nerve activity (RSNA) and renal blood flow (RBF) were examined in conscious rats. Administration of ANP had no appreciable effects on baseline RSNA and RBF. The pressor response induced by i.c.v. ang...

journal_title：Neuroscience letters

authors： Kannan H,Ueta Y,Nakamura T,Yamashita H,Hayashida Y

更新日期：1990-08-14 00:00:00

abstract：:In the toad Xenopus laevis, the microtubular density of 3-microns myelinated fibres was assessed in peripheral nerves, dorsal and ventral roots, and dorsal and ventral funiculi of the spinal cord. In the roots, the axonal microtubular density was 6 microtubules/microns 2 and twice as much at the other sampling sites. ...

journal_title：Neuroscience letters

authors： Saitua F,Alvarez J

更新日期：1989-10-09 00:00:00

abstract：:The effect of electrical stimulation of the dorsal hippocampus on accumbens dopamine release was examined. Stimulation of the kindled hippocampus that produced stage 3 seizures evoked a brief increase in extracellular DA and DOPAC levels in the contralateral nucleus accumbens. In contrast, similar stimulation early in...

journal_title：Neuroscience letters

authors： Strecker RE,Moneta ME

更新日期：1994-08-01 00:00:00

abstract：:There is little information available on the mechanisms underlying the neuroprotective actions of the organoselenium compound ebselen. In this study, we sought to determine the relationship between alterations in the expression of Bcl-2 and Bax proteins and intracellular levels of calcium and the protective effects of...

journal_title：Neuroscience letters

authors： Xu JH,Hu HT,Liu Y,Qian YH,Liu ZH,Tan QR,Zhang ZJ

更新日期：2006-05-22 00:00:00

abstract：:Cyclins are regulatory proteins of the cell cycle which bind and activate kinases. In gliomas, contrary to many malignancies, cyclin D1 is rarely amplified, but together with other cyclins, it increases with anaplasia. In a series of 23 surgical biopsies of grade II and III oligodendroglioma, cyclin D1, E, A, B1, CDK4...

journal_title：Neuroscience letters

authors： Fiano V,Ghimenti C,Schiffer D

更新日期：2003-08-21 00:00:00

abstract：:During neuromuscular development, the nerve induces the expression of acetylcholine receptor (AChR) epsilon-subunit gene selectively in synaptic myonuclei. Here we show that even after elimination of neural effects by denervation, synaptic expression of epsilon-subunit transcripts is maintained for > 4 months. In cont...

journal_title：Neuroscience letters

authors： Herczeg A,Jones G,Brenner HR

更新日期：1995-06-23 00:00:00

abstract：:Twenty years ago, Wolfe, Xia, and Selkoe identified two aspartate residues in Alzheimer's presenilin protein that constitute the active site of the γ-secretase complex. Mutations in the genes encoding amyloid precursor protein (APP) or presenilin (PS) cause early onset familial Alzheimer's disease (AD), and sequential...

journal_title：Neuroscience letters

authors： Xia W

更新日期：2019-05-14 00:00:00

abstract：:Supporting cell mitosis contributes significantly to hair cell regeneration in the acoustically damaged bird inner ear. Yet there may be another mechanism of hair cell replacement: supporting cell conversion. This study used cytosine arabinoside (Ara-C), an inhibitor of DNA synthesis, to better determine whether suppo...

journal_title：Neuroscience letters

authors： Adler HJ,Raphael Y

更新日期：1996-02-16 00:00:00

abstract：:The present study was designed to determine whether the p53 tumor-suppressor protein is involved in the development of antinociceptive tolerance to morphine. When the doses of morphine (mg/kg per injection) were subcutaneously given into mice as pretreatment twice daily for 2 days (first day (30) and second day (60)),...

journal_title：Neuroscience letters

authors： Tan-No K,Shimoda M,Watanabe K,Nakagawasai O,Niijima F,Kanno S,Ishikawa M,Bakalkin G,Tadano T

更新日期：2009-02-06 00:00:00

abstract：:In neurodegenerative diseases, such as Alzheimer's disease or HIV encephalitis, neuronal DNA fragmentation has been observed at unexpected high frequencies, without definitive evidence for activation of an irreversible apoptotic pathway. The wobbler mouse is a suggested genetic model of neurodegenerative disease. The ...

journal_title：Neuroscience letters

authors： Blondet B,Aït-Ikhlef A,Murawsky M,Rieger F

更新日期：2001-06-15 00:00:00

abstract：:Intracellular recordings were made in slices of human neocortex removed for surgical treatment of epilepsy. In response to prolonged suprathreshold current injection, regular spiking neurons (67.5% of sample) responded by repetitive firing throughout the stimulus from all membrane potentials. Bursting neurons (32.5% o...

journal_title：Neuroscience letters

authors： Foehring RC,Wyler AR

更新日期：1990-03-14 00:00:00

abstract：:Neuroimaging studies have identified cognitive tasks that can selectively activate specific parts of the brains. However, the subsequent effect of localized brain activation on the cognitive functioning remains unclear. We discovered that after being engaged in the novel picture encoding task to activate hippocampus f...

journal_title：Neuroscience letters

authors： Chan AS,Cheung M,Ho Y,Jing He W

更新日期：2000-04-07 00:00:00

abstract：:Five monoclonal antibodies specific for rat monocytes/macrophages were used to characterize macrophages/microglia bulk isolated from neonatal and adult rat brain. The majority of brain macrophages was positive for all antibodies tested with minor differences between cultures derived from developing and mature central ...

journal_title：Neuroscience letters

authors： Graeber MB,Banati RB,Streit WJ,Kreutzberg GW

更新日期：1989-09-11 00:00:00

abstract：:Imaging studies indicate smaller orbitofrontal cortex (OFC) volume in mood disorder patients compared with healthy subjects. We sought to determine whether child and adolescent patients with bipolar disorder have smaller OFC volumes than healthy controls. Fourteen children and adolescents meeting DSM-IV criteria for b...

journal_title：Neuroscience letters

authors： Najt P,Nicoletti M,Chen HH,Hatch JP,Caetano SC,Sassi RB,Axelson D,Brambilla P,Keshavan MS,Ryan ND,Birmaher B,Soares JC

更新日期：2007-02-21 00:00:00

abstract：:The purpose of this study was to characterize the neuromuscular control during shortening (SHO) and lengthening (LEN) contractions by investigating the input-output (I/O) property in the corticospinal tract. To this end, the relation between various stimulus intensities applied via transcranial magnetic stimulation an...

journal_title：Neuroscience letters

authors： Sekiguchi H,Kimura T,Yamanaka K,Nakazawa K

更新日期：2001-10-19 00:00:00

abstract：:The anatomical relationships between pro-opiomelanocortin-containing axons and serotonin neurons in the nucleus raphe dorsalis (NRD) of the rat were examined at the light microscope level with antibodies against CLIP (corticotropin-like intermediate lobe peptide), alpha-MSH (alpha-melanocyte-stimulating hormone) and s...

journal_title：Neuroscience letters

authors： Zheng Z,Léger L,Cespuglio R,Jouvet M

更新日期：1991-09-02 00:00:00

abstract：:We studied the influence of caffeine treatment (50 mg/kg for 3 doses) on catecholamine utilization and adrenergic receptor binding in female rats. Caffeine enhanced the reduction in forebrain norepinephrine levels following alpha-methyl-p-tyrosine without altering the reduction in dopamine levels. Caffeine reduced the...

journal_title：Neuroscience letters

authors： Goldberg MR,Curatolo PW,Tung CS,Robertson D

更新日期：1982-07-20 00:00:00

abstract：:Afferent fibers ending in nerve-end neuromas generate spontaneous impulse discharge which has been implicated as a cause of paraesthesias and pain following peripheral nerve injury in man. We now show in rats that the anticonvulsant drug phenytoin (PT), applied systemically or topically onto desheathed neuromas, suppr...

journal_title：Neuroscience letters

authors： Yaari Y,Devor M

更新日期：1985-07-04 00:00:00

abstract：:Brachial plexus avulsion (BPA) is one of the major injuries in motor vehicle accidents and may result in neuropathic pain. Accumulating evidence suggests that 30-80% of BPA developed neuropathic pain in human. In our study, complete brachial plexus avulsion (C5-T1) rats model leads to the results that 37.5% of rats ha...

journal_title：Neuroscience letters

authors： Wang L,Yuzhou L,Yingjie Z,Jie L,Xin Z

更新日期：2015-03-04 00:00:00

abstract：:Intracellular recording techniques were used to monitor the evoked responses in hippocampal CA1 pyramidal cells following focal stimulation of the proximally and distally located apical dendritic synapses. The local anaesthetic, QX-314, when injected into individual cells, caused a complete time-dependent blockade of ...

journal_title：Neuroscience letters

authors： Colling SB,Wheal HV

更新日期：1994-05-19 00:00:00

abstract：:Hypoxic-ischemic brain damage (HIBD) leads to acute death and chronic neurological dysfunction in neonates. To date, there is no satisfactory acknowledged strategy to provide neuroprotection completely. Verbascoside (VB) has been proved to possess antioxidative, anti aging and neuroprotective activities. The aim of th...

journal_title：Neuroscience letters

authors： Wei W,Lu M,Lan X,Liu N,Wang H,Du J,Sun T,Li Y,Yu J

更新日期：2019-10-15 00:00:00

abstract：:We examined the distribution of ferric ion-ferrocyanide stain (a marker for excitable regions of myelinated fibers) in the lead-induced demyelinating neuropathy of the rat. By electron microscopy, we found that paranodal degeneration resulted in spreading of the reaction product from nodal to internodal axolemma. Duri...

journal_title：Neuroscience letters

authors： Coria F,Silos I,Fernandez R,Monton F,Lafarga M

更新日期：1985-08-05 00:00:00

abstract：:Glucose uptake is increased during motoneuron regeneration. Since this glucose is probably used as an energy source for axonal regeneration we postulated that hypoglycemia might interfere with motoneuron regeneration. In order to partially test this hypothesis we attempted to induce moderate hypoglycemia by fasting ra...

journal_title：Neuroscience letters

authors： Singer PA,Mehler S

更新日期：1983-10-31 00:00:00

abstract：:Restoring corticospinal function after spinal cord injury is a significant challenge as the corticospinal tract elicits no substantive, spontaneous regeneration, and its interruption leaves a permanent deficit. The corticospinal circuit serves multiple motor and sensory functions within the mammalian nervous system as...

journal_title：Neuroscience letters

authors： Serradj N,Agger SF,Hollis ER 2nd

更新日期：2017-06-23 00:00:00

abstract：:125I-Staphylococcal protein A was used to visualize immunoreactive cell antigen in rat brain and pituitary by autoradiography. Autoradiograms of rat brain sections generated with 125I-protein A were clear and showed low background signals. We were able to visualize neural structures containing tyrosine hydroxylase or ...

journal_title：Neuroscience letters

authors： Correa FM,Guilhaume SS,Saavedra JM

更新日期：1988-06-29 00:00:00

abstract：:Centrally formed acetaldehyde has proven to be responsible for several psychopharmacological effects induced by ethanol. In addition, it has been suggested that the cAMP-PKA signaling transduction pathway plays an important role in the modulation of several ethanol-induced behaviors. Therefore, we hypothesized that ac...

journal_title：Neuroscience letters

authors： Tarragon E,Baliño P,Aragon CM

更新日期：2014-09-19 00:00:00

abstract：:Assessments of the pharmacological profiles of antipsychotic agents have shown that the serotonin receptor family is often involved in their pharmacodynamics. Response to antipsychotic therapy is highly variable, yet prognostic biomarkers are lacking. The aim of the study was to investigate the association of 14 singl...

journal_title：Neuroscience letters

authors： Zhou W,Chang W,Yan Y,Shen L,Li W,Yi Z,Qin S

更新日期：2018-09-14 00:00:00

abstract：:In this study, we have developed a microarray including 1467 cDNAs that were selected to specifically measure stress response in peripheral blood leukocytes. Venous blood was collected from 10 graduate students 2 h before and 2 or 24 h after an open presentation for their Ph.D. The mRNA levels in leukocytes were compa...

journal_title：Neuroscience letters

authors： Morita K,Saito T,Ohta M,Ohmori T,Kawai K,Teshima-Kondo S,Rokutan K

更新日期：2005-06-10 00:00:00

abstract：:The irreversible opiate antagonists beta-funaltrexamine (beta-FNA) and beta-chlornaltrexamine (beta-CNA) were injected into rat striatum. One day later, mu-opioid receptor binding, as assessed by receptor autoradiography, was abolished in the injected striatum, while [3H]spiperone binding remained largely unaffected. ...

journal_title：Neuroscience letters

authors： Morris BJ,Höllt V,Herz A

更新日期：1988-06-17 00:00:00

abstract：:Small-fiber neuropathy was induced in young adult mice by intraperitoneal injection of resiniferatoxin (RTX), a TRPV1 agonist. At day 7, RTX induced significant thermal and mechanical hypoalgesia. At day 28, mechanical and thermal nociception were restored. No nerve degeneration in skin was observed and unmyelinated n...

journal_title：Neuroscience letters

authors： Danigo A,Magy L,Richard L,Sturtz F,Funalot B,Demiot C

更新日期：2014-06-13 00:00:00