当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Neurotrophic factors increase tumor necrosis factor-alpha-induced nuclear translocation of NF-kappaB in rat PC12 cells.

Neurotrophic factors increase tumor necrosis factor-alpha-induced nuclear translocation of NF-kappaB in rat PC12 cells.

Abstract：

:Neurotrophic factors regulate neuronal survival and differentiation and control neurite outgrowth by binding to tyrosine kinase receptors, the Trks, and a tumor necrosis factor (TNF) receptor-like molecule, p75 neurotrophin receptor. A proinflammatory cytokine, TNF, also affects survival and apoptotic death in neuronal cells. However, it is still unclear whether neurotrophic factors and TNF co-operate the intracellular signaling. Using green fluorescent protein-tagged NF-kappaB1 (GFP-NF-kappaB1), we examined here the effects of TNF-alpha and neurotrophic factors on the nuclear translocation of NF-kappaB in PC12 cells. TNF-alpha induced gradually the translocation of GFP-NF-kappaB1 from the cytoplasm to the nucleus within 60 min. Pretreatment of lactacystin which is a proteasome-specific inhibitor suppressed significantly the nuclear translocation of GFP-NF-kappaB1 after TNF-alpha stimulation. In addition, we found that co-stimulation of TNF-alpha and neurotrophic factors such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) increased greatly the nuclear translocation of GFP-NF-kappaB1 whereas neither NGF nor BDNF itself induced the translocation. These results suggested that there is a close correlation between the signaling pathways via TNF receptors and neurotrophin receptors for the NF-kappaB activation, and that NGF and BDNF enhance TNF-alpha-induced nuclear translocation of NF-kappaB.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Furuno T,Nakanishi M

doi

10.1016/j.neulet.2005.09.031

keywords:

subject

Has Abstract

pub_date

2006-01-16 00:00:00

pages

240-4

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(05)01091-8

journal_volume

392

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Dual efferent projections of the trigeminal principal sensory nucleus to the thalamic ventroposteromedial nucleus in the squirrel monkey.

    abstract：:Anterograde degeneration methods demonstrated two efferent components from the trigeminal principal sensory nucleus (PrV) to the thalamic ventroposteromedial nucleus (VPM) in the squirrel monkey: fibers from the dorsal PrV coursed within the central tegmental tract and terminated in a dorsoventromedial strip of the ip...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90138-2

    authors： Ganchrow D,Mehler WR

    更新日期：1986-07-24 00:00:00

  • Transient up-regulation of elongation factor-2 kinase (Ca2+/calmodulin-dependent protein kinase III) messenger RNA in developing mouse brain.

    abstract：:Elongation factor-2 kinase (eEF-2K) is a Ca(2+)/calmodulin-dependent protein kinase that is highly specific for eukaryotic elongation factor-2. In the present study, we examined the developmental expression of eEF-2K messenger RNA (mRNA) in the mouse brain. At E13, the expression of eEF-2K mRNA is already evident in b...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)00715-2

    authors： Sakagami H,Nishimura H,Saito R,Kondo H

    更新日期：2002-09-13 00:00:00

  • Sleep-associated variations in plasma renin activity and blood pressure in the rat.

    abstract：:Plasma renin activity (PRA) was determined in plasma samples obtained approximately at 6-min intervals during consecutive non-rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS) periods in rats chronically implanted with EEG electrodes, a brain thermistor, and an intracardiac catheter. PRA was low in ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(94)90940-7

    authors： Obál F Jr,Beranek L,Brandenberger G

    更新日期：1994-09-26 00:00:00

  • Neural correlates of delayed episodic memory in patients with mild cognitive impairment--a FDG PET study.

    abstract：:Mild cognitive impairment (MCI) is characterized by cognitive deficits which do not yet reach the threshold of dementia but represent a putative preclinical state of Alzheimer's disease (AD). Little is known about the neural correlates of delayed episodic memory which is among the earliest signs of cognitive decline i...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.10.014

    authors： Schönknecht OD,Hunt A,Toro P,Henze M,Haberkorn U,Schröder J

    更新日期：2009-12-25 00:00:00

  • Circadian rhythm of nitric oxide production in the dorsal region of the suprachiasmatic nucleus in rats.

    abstract：:Extracellular concentration of nitrite (NO2-), an oxidized product of nitric oxide (NO), was measured consecutively in the dorsal region of the rat suprachiasmatic nucleus (SCN) by means of in vivo microdialysis. The NO2- concentrations in the dialysates showed robust circadian rhythm under a 12:12 h light/dark cycle ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)01744-x

    authors： Mitome M,Shirakawa T,Oshima S,Nakamura W,Oguchi H

    更新日期：2001-05-11 00:00:00

  • Sexual behavior in Aplysia fasciata induced by homogenates of the distal large hermaphroditic duct.

    abstract：:Copulation was induced in pairs of Aplysia fasciata by adding to the environment a homogenate of the distal portion of the large hermaphroditic duct. Similar effects were not observed in response to an abdominal ganglion homogenate. The data suggest that the duct may secrete a pheromone initiating copulation in Aplysi...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(85)90153-3

    authors： Susswein AJ,Benny M

    更新日期：1985-09-06 00:00:00

  • Rapid interaction of tetraethylammonium with delayed K+ channel in mammalian brain neuron.

    abstract：:In order to study the rapidity of interaction between tetraethylammonium (TEA) and the delayed K+ channel of the mammalian brain neuron, TEA was applied to isolated rat hippocampal pyramidal neurons in a time-controlled sequence with a voltage step using a concentration clamp technique. TEA at a concentration of 30 mM...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90601-o

    authors： Oyama Y,Harata N,Akaike N

    更新日期：1991-10-14 00:00:00

  • Letrozole induces worse hippocampal synaptic and dendritic changes and spatial memory impairment than ovariectomy in adult female mice.

    abstract：:Estrogens (E2) derived from ovaries and/or local de novo synthesis in the hippocampus profoundly regulate hippocampal structure and function, but the importance of local E2 versus ovarian E2 on hippocampal synaptic plasticity and spatial memory has not been well elucidated. The present study used ovariectomy (OVX) and...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2019.05.006

    authors： Liu M,Xing F,Bian C,Zhao Y,Zhao J,Liu Y,Zhang J

    更新日期：2019-07-27 00:00:00

  • Leucine-rich glioma inactivated 3 associates with syntaxin 1.

    abstract：:Leucine-rich glioma inactivated 3 (LGI3) is a member of LGI/epitempin (EPTP) family. The biological function of LGI3 and its association with disease are not known. We previously reported that mouse LGI3 was highly expressed in brain in a developmentally and transcriptionally regulated manner. In this study, we identi...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.08.044

    authors： Park WJ,Lee SE,Kwon NS,Baek KJ,Kim DS,Yun HY

    更新日期：2008-10-31 00:00:00

  • Two thalamo-telencephalic pathways in a urodele, Triturus alpestris.

    abstract：:Ascending thalamo-telencephalic projection systems have been investigated in an urodele, Triturus alpestris, using the horseradish peroxidase technique. Two separate dorsal thalamic projections onto the telencephalon have been identified; one arises from the posterior dorsal thalamus and terminates in the ipsilateral ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90235-1

    authors： Wicht H,Himstedt W

    更新日期：1986-07-11 00:00:00

  • Potentiation of human alpha4beta2 neuronal nicotinic receptors by a Flustra foliacea metabolite.

    abstract：:The effects of various Flustra foliacea metabolites on different types of human neuronal nicotinic acetylcholine receptors (nAChRs) expressed in Xenopus oocytes were investigated. Whereas most of the compounds tested had a small blocking effect, one of them, deformylflustrabromine, selectively increased the current ob...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2004.10.002

    authors： Sala F,Mulet J,Reddy KP,Bernal JA,Wikman P,Valor LM,Peters L,König GM,Criado M,Sala S

    更新日期：2005-01-10 00:00:00

  • Co-release of acetylcholine, glutamate and taurine from synaptosomes of Torpedo electric organ.

    abstract：:The amino acid content of Torpedo synaptosomes was investigated. It was found that glutamate and taurine were particularly enriched, their concentration exceeding that of acetylcholine by 50-60%. Other amino acids such as alanine, gamma-aminobutyric acid (GABA), glycine, leucine and phenylalanine were also present, bu...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(87)90171-6

    authors： Vyas S,Bradford HF

    更新日期：1987-11-10 00:00:00

  • Reproduction of scalp acupuncture therapy on strokes in the model rats, spontaneous hypertensive rats-stroke prone (SHR-SP).

    abstract：:Scalp acupuncture (SA) therapy on strokes has been empirically established and widely used in clinics in China. SA is particularly effective at ameliorating paralyses and speech disturbances, and the recovery rate is twice that for those treated with medication alone. To investigate the effects of SA on a scientific b...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)01032-7

    authors： Inoue I,Chen L,Zhou L,Zeng X,Wang H

    更新日期：2002-11-29 00:00:00

  • Chloroquine specifically impairs Merkel cell mechanoreceptor function in isolated rat sinus hairs.

    abstract：:The function of Merkel cells in mechanotransduction has remained controversial Single unit recordings were made from Merkel cell receptors (sinus hair type I, St I) and another slowly adapting mechanoreceptor (sinus hair type II, St II) in isolated rat sinus hairs by applying controlled mechanical displacements to the...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(96)12906-2

    authors： Senok SS,Halata Z,Baumann KI

    更新日期：1996-08-23 00:00:00

  • Variations in the effects of L-methionine-DL-sulfoximine on the activity of cerebral gamma-glutamyl transpeptidase in rats as a function of age.

    abstract：:Changes in the activity of gamma-glutamyl transpeptidase (GGTP) and the effects of a subacute dose (150 mg/kg b.wt.) of methionine sulfoximine (MSO) on its activity were studied in cerebral cortex, cerebellum and brainstem of rats of 4 different age groups. GGTP activity increased with increasing age between days 10 a...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90359-2

    authors： Rao VL,Murthy CR

    更新日期：1991-05-13 00:00:00

  • Neuronal overexpression of cyclooxygenase-2 does not alter the neuroinflammatory response during brain innate immune activation.

    abstract：:Neuroinflammation is a critical component in the progression of several neurological and neurodegenerative diseases and cyclooxygenases (COX)-1 and -2 are key regulators of innate immune responses. We recently demonstrated that COX-1 deletion attenuates, whereas COX-2 deletion enhances, the neuroinflammatory response,...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.04.076

    authors： Aid S,Parikh N,Palumbo S,Bosetti F

    更新日期：2010-07-12 00:00:00

  • Secretory cleavage of beta-amyloid precursor protein in the cerebral white matter produces amyloidogenic carboxyl-terminal fragments.

    abstract：:To elucidate the metabolic process generating amyloid-beta protein (A beta) from beta-amyloid precursor protein (APP) in human brain, we partially purified secretory forms and carboxyl-terminal fragments (CTFs) of APP from the white matter of a Down's syndrome brain. We obtained secretory forms of APP which lack the e...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(95)11307-i

    authors： Tokuda T,Tanaka K,Kametani F,Ikeda S,Yanagisawa N

    更新日期：1995-02-17 00:00:00

  • Forskolin induced increase in spontaneous activity of auditory brainstem neurons is comparable to acoustic stimulus evoked responses.

    abstract：:Contemporary proposals for the pathophysiology of tinnitus due to cochlear damage underscore increased spontaneous activity of auditory brainstem neurons. One of the several consequences of the cochlear injury is the activation of the ERK pathway, suppression of phosphodiestase E activity, and putatively setting a lon...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.10.053

    authors： Shaikh AG,Finlayson PG

    更新日期：2012-12-07 00:00:00

  • Evaluation of age-related plantar-surface insensitivity and onset age of advanced insensitivity in older adults using vibratory and touch sensation tests.

    abstract：:Age-related decline in plantar-surface sensitivity has been cited as one of the reasons for balance problems in older adults. This study investigated the level of plantar-surface sensitivity in older adults compared to young adults. Additionally, this study attempted to identify the onset age of advanced insensitivity...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.08.060

    authors： Perry SD

    更新日期：2006-01-09 00:00:00

  • The effects of dorsal rhizotomy and spinal cord isolation on calcitonin gene-related peptide-labeled terminals in the rat lumbar dorsal horn.

    abstract：:In the present study, the origin of calcitonin gene-related peptide (CGRP) to the dorsal horn in the rat lumbar spinal cord is investigated. CGRP immunoreactivity is examined following multiple unilateral and bilateral dorsal rhizotomies and isolated cord preparations (spinal cords are isolated by transecting the cord...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(88)90781-1

    authors： Chung K,Lee WT,Carlton SM

    更新日期：1988-07-19 00:00:00

  • Effects of L-carnosine on splenic sympathetic nerve activity and tumor proliferation.

    abstract：:l-Carnosine (β-alanyl-l-histidine), a dipeptide of the amino acids β-alanine and histidine, is found in mammalian tissues including those in the central nervous system and in skeletal muscles. In the present study, we examined the effects of intraduodenal (ID) injection of l-carnosine on splenic sympathetic nerve acti...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.12.058

    authors： Horii Y,Shen J,Fujisaki Y,Yoshida K,Nagai K

    更新日期：2012-02-21 00:00:00

  • Respiratory and cardiovascular actions of orexin-A in mice.

    abstract：:Ample evidence has been reported to show a probable contribution of orexin in the central cardiovascular regulation. Although cardiovascular and respiratory centers in the brain are located close to each other and are interconnected, the possible participation of orexin in respiratory regulation has not been fully doc...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.05.032

    authors： Zhang W,Fukuda Y,Kuwaki T

    更新日期：2005-09-09 00:00:00

  • Parvalbumin as an anatomical marker for discrete subregions of the ambiguus complex in the rat.

    abstract：:The topography of parvalbumin-immunoreactive neurons within the ventrolateral medulla of rats was investigated. Parvalbumin is a member of the 'EF-hand' family of Ca-binding proteins and is present in certain cell types within the central nervous system (fast-firing neurons with high metabolic rates). Parvalbumin-immu...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(93)90923-9

    authors： Cox M,Halliday GM

    更新日期：1993-09-17 00:00:00

  • Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia.

    abstract：:Mice exposed to intermittent cold stress (ICS), but not constant cold stress (CCS) showed sustained thermal hyperalgesia for up to 12 days. Systemic or intracerebroventricular (i.c.v.) injection of morphine caused no significant analgesia in ICS mice, but induced dose-dependent analgesia in control mice. However, sign...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.01.080

    authors： Nishiyori M,Nagai J,Nakazawa T,Ueda H

    更新日期：2010-03-26 00:00:00

  • Distribution of the pro-opiomelanocortin-immunoreactive axons in relation to the serotoninergic neurons in the dorsal raphe nucleus of the rat.

    abstract：:The anatomical relationships between pro-opiomelanocortin-containing axons and serotonin neurons in the nucleus raphe dorsalis (NRD) of the rat were examined at the light microscope level with antibodies against CLIP (corticotropin-like intermediate lobe peptide), alpha-MSH (alpha-melanocyte-stimulating hormone) and s...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90217-h

    authors： Zheng Z,Léger L,Cespuglio R,Jouvet M

    更新日期：1991-09-02 00:00:00

  • Effect of strychnine on cardiac vagal inhibition.

    abstract：:Strychnine blocked the vagal-induced cardiac inhibition in both perfused frog heart and dog's heart in situ. This effect was antagonized by eserine. The present results are consistent with our previous findings that strychnine blocks the cholinergic inhibitory mechanisms both in the central nervous system as well as i...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(77)90153-7

    authors： Bhargava VK,Bhargava P,Tripathi KD

    更新日期：1977-02-01 00:00:00

  • Enhancing the anterograde movement of HRP to label sparse neuronal projections.

    abstract：:By combining techniques designed to increase the amount of horseradish peroxidase (HRP) available for transport and to improve the sensitivity of the reaction for detecting HRP, we have produced an anterograde HRP technique suitable for labeling sparse efferent projections. The efficacy of this light, microscopic tech...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(79)91476-9

    authors： West JR,Black AC Jr

    更新日期：1979-04-01 00:00:00

  • Degeneration of corticospinal and bulbospinal systems in the superoxide dismutase 1(G93A G1H) transgenic mouse model of familial amyotrophic lateral sclerosis.

    abstract：:In the superoxide dismutase 1 (SOD1)(G93A G1H) transgenic mouse, the primary pathology and disease signs are associated with the degeneration of motor neurons in the lumbar spinal cord. It is unclear if the descending motor pathways from the cortex and brainstem are also compromised. The retrograde tracer Fluorogold w...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)00944-8

    authors： Zang DW,Cheema SS

    更新日期：2002-10-31 00:00:00

  • Dilation of the inferior colliculus and hypersensitivity to sound in Wnt1-cre and Wnt1-GAL4 double-transgenic mice.

    abstract：:The processing of sound information is mediated by the cochlea and the central auditory system. Among the central auditory system, the inferior colliculus (IC) has leading roles in the acoustic processing. In a previous study, we demonstrated psychiatric disorder-related behavioral abnormalities in a genetically modif...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.02.061

    authors： Nakajima M,Nishikawa C,Miyasaka Y,Kikkawa Y,Mori H,Tsuruta M,Okuyama S,Furukawa Y

    更新日期：2014-04-30 00:00:00

  • Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology.

    abstract：:Expression levels of amyloid beta (Abeta)-degrading enzymes, insulin degrading enzyme (IDE) and neprilysin (NEP), were examined in transgenic mice with Alzheimer's disease-like neuropathology. After the development of first Abeta plaques in transgenic mice brain, cortical mRNA and protein levels of IDE were significan...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.04.025

    authors： Vepsäläinen S,Hiltunen M,Helisalmi S,Wang J,van Groen T,Tanila H,Soininen H

    更新日期：2008-06-20 00:00:00