Abstract:
:Mild cognitive impairment (MCI) is characterized by cognitive deficits which do not yet reach the threshold of dementia but represent a putative preclinical state of Alzheimer's disease (AD). Little is known about the neural correlates of delayed episodic memory which is among the earliest signs of cognitive decline in patients at risk of developing AD. We performed resting state positron emission tomography (PET) with (18)Fluorodeoxyglucose (FDG) in patients with MCI, and hypothesized a correlation between delayed episodic memory performance and frontal glucose metabolism since the latter is relatively spared in the preclinical phase of the disease. 43 patients (age: 69.7+/-7.9 years; 24 male, 19 female) with MCI were investigated by FDG PET. Significant positive correlations with delayed episodic memory performance were calculated by statistical parametric mapping. To our knowledge the present study is the first to demonstrate by FDG PET the neural correlates of delayed episodic memory in patients with MCI. Our study revealed a pattern of cerebral glucose metabolism including bifrontal regions which may contribute to the delayed episodic memory performance of patients with MCI. Since not all patients with MCI will further deteriorate, AD specific mechanism may not be concluded from the present study but warrant longitudinal investigations.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Schönknecht OD,Hunt A,Toro P,Henze M,Haberkorn U,Schröder Jdoi
10.1016/j.neulet.2009.10.014subject
Has Abstractpub_date
2009-12-25 00:00:00pages
100-4issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(09)01324-Xjournal_volume
467pub_type
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