Potentiation of human alpha4beta2 neuronal nicotinic receptors by a Flustra foliacea metabolite.

abstract：:The autonomic nervous system (ANS) is implicated in maintaining homeostasis of the internal environment in mammals. Therefore, changes occurring in the ANS can cause alterations of physiological phenomena. Ethyl hexanoate (EH) is known as the aroma component of apples. To study the action of ethyl hexanoate on physiol...

journal_title：Neuroscience letters

authors： Horii Y,Fujisaki Y,Misonou Y,Fuyuki R,Nagai K

更新日期：2020-10-15 00:00:00

abstract：:Methamphetamine (METH) is a well-known drug of abuse and neurotoxin that may cause temporary or permanent disturbances in the dopaminergic systems of the brain, predisposing individuals to Parkinsonism. Previously, we have shown that METH causes dopaminergic cell death by increasing the production of reactive oxygen s...

journal_title：Neuroscience letters

authors： Ajjimaporn A,Phansuwan-Pujito P,Ebadi M,Govitrapong P

更新日期：2007-05-23 00:00:00

abstract：:Orexins (OXs) stimulate sympathetic nerve activity to increase arterial pressure (AP) and heart rate (HR). We have previously reported that the OX(1)-receptor antagonist SB-334867 reversed the sympathomimetic actions of orexin A (OXA). In the present study we have investigated the role(s) of the orexinergic system in ...

journal_title：Neuroscience letters

authors： Hirota K,Kushikata T,Yoshida H,Kudo M,Kudo T

更新日期：2008-02-20 00:00:00

abstract：:Supporting cell mitosis contributes significantly to hair cell regeneration in the acoustically damaged bird inner ear. Yet there may be another mechanism of hair cell replacement: supporting cell conversion. This study used cytosine arabinoside (Ara-C), an inhibitor of DNA synthesis, to better determine whether suppo...

journal_title：Neuroscience letters

authors： Adler HJ,Raphael Y

更新日期：1996-02-16 00:00:00

abstract：:To investigate changes in regional cerebral blood flow (rCBF) under the prone condition with and without light massage on the back, we measured rCBF quantitatively in healthy human subjects using positron emission tomography with H(2)15O. Biochemical tests showed that the light massage (palm-pressure) reduced levels o...

journal_title：Neuroscience letters

authors： Ouchi Y,Kanno T,Okada H,Yoshikawa E,Shinke T,Nagasawa S,Minoda K,Doi H

更新日期：2006-10-23 00:00:00

abstract：:Dysregulated brain glucose metabolism and lactate accumulation are seen following traumatic brain injury (TBI). The underlying molecular mechanism is poorly understood. Pyruvate dehydrogenase (PDH), the rate-limiting enzyme coupling cytosolic glycolysis to mitochondrial citric acid cycle, plays a critical role in main...

journal_title：Neuroscience letters

authors： Xing G,Ren M,Watson WD,O'Neill JT,Verma A

更新日期：2009-04-17 00:00:00

abstract：:The N-methyl-D-aspartic acid subclass of glutamate receptors is thought to be involved in events that depend on repetitive activation of neurons. The present study shows that repetitive stimulation of CA3 can produce epileptiform discharges in the contralateral dentate gyrus. This distinctive paroxysmal response was b...

journal_title：Neuroscience letters

authors： Stringer JL,Lothman EW

更新日期：1988-09-23 00:00:00

abstract：:Oral administration of naloxone (10 mg/kg) antagonized the slowing of the intestinal transit caused by oral morphine (1, 2.5 and 5 mg/kg) in rats. Oral administration of naloxone (10 mg/kg) did not prevent the antinociceptive effect of orally administered morphine (2.5 mg/kg) in the tail-flick test carried out on rats...

journal_title：Neuroscience letters

authors： Jurna I,Kaiser R,Kretz O,Baldauf J

更新日期：1992-08-03 00:00:00

abstract：:Prefoldin is a molecular chaperone that assists the folding of newly synthesized polypeptide chains and prevents aggregation of misfolded proteins. Dysfunction of prefoldin is one of the causes of neurodegenerative diseases such as Alzheimer's disease. The aim of this study was to clarify the involvement of prefoldin ...

journal_title：Neuroscience letters

authors： Kadoyama K,Matsuura K,Takano M,Maekura K,Inoue Y,Matsuyama S

更新日期：2019-11-01 00:00:00

abstract：:It is well known that genetic variants play a critical role in the pathogenesis of Alzheimer's disease (AD). In 2009, a genome-wide association study (GWAS) demonstrated that a single nucleotide polymorphism (SNP), rs6656401, in complement receptor 1 (CR1) is significantly associated with late-onset Alzheimer's diseas...

journal_title：Neuroscience letters

authors： Jin C,Li W,Yuan J,Xu W,Cheng Z

更新日期：2012-10-03 00:00:00

abstract：:Restoring corticospinal function after spinal cord injury is a significant challenge as the corticospinal tract elicits no substantive, spontaneous regeneration, and its interruption leaves a permanent deficit. The corticospinal circuit serves multiple motor and sensory functions within the mammalian nervous system as...

journal_title：Neuroscience letters

authors： Serradj N,Agger SF,Hollis ER 2nd

更新日期：2017-06-23 00:00:00

abstract：:We recently reported here that SNCA triplication results in a doubling in the amount of alpha-synuclein protein in blood from cases with hereditary Lewy body disease. This observation shows that alpha-synuclein levels in blood accurately reflect gene dosage, which we assume drives pathogenesis in these individuals. A ...

journal_title：Neuroscience letters

authors： Miller DW,Crawley A,Gwinn-Hardy K,Lopez G,Nussbaum R,Cookson MR,Singleton AB,Hardy J,Dogu O

更新日期：2005-02-21 00:00:00

abstract：OBJECTIVE:Exploring the impact of glucocerebrosidase gene (GBA) polymorphisms and mutations on the pathogenesis of Parkinson's disease dementia (PDD) plays an important role in the diagnosis and treatment of this disease. This meta-analysis aimed to investigate the effects of GBA polymorphisms and mutations on the risk...

journal_title：Neuroscience letters

authors： Zhang Y,Chen J,Xu C,Feng J,Li J

更新日期：2020-01-01 00:00:00

abstract：:In anesthetized rats, injections of a 0.5 mM glutamate solution into the locus coeruleus (LC) reversibly increased the amplitude of the population spike evoked in CA1 by stimulation of the Schaffer-commissural fiber tract. This effect was absent in N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4)-treated, noradren...

journal_title：Neuroscience letters

authors： Olpe HR,Laszlo J,Pozza MF,De Herdt P,Waldmeier PC,Jones RS

更新日期：1986-03-28 00:00:00

abstract：:The neurotoxin 6-hydroxydopamine (6-OHDA) is used to induce dopaminergic cell death, resulting in insufficient striatal dopamine content in the basal ganglia and motor dysfunction typical of Parkinson's disease. Dopamine induces release of the neuropeptide substance P (SP) within the substantia nigra, whereas SP is ab...

journal_title：Neuroscience letters

authors： Thornton E,Tran TT,Vink R

更新日期：2010-08-30 00:00:00

abstract：:We studied axonal branching of 14 parabrachial nucleus neurons, activated antidromically from 2 of the 3 stimulation sites, i.e. the ipsi- and contralateral thalamic taste area (TTAs) and the ipsilateral central nucleus of the amygdala (CA). Making use of antidromic latencies, collision times and refractory periods at...

journal_title：Neuroscience letters

authors： Hayama T,Ogawa H

更新日期：1987-12-16 00:00:00

abstract：:Cytoplasmic acidification in taste receptor cells is thought to be involved, at least in part, in acid taste transduction. Since in taste buds about 20% of the receptor cells are electrically coupled, we have tested whether reduction in intracellular pH affects these lateral synaptic interactions. By applying the patc...

journal_title：Neuroscience letters

authors： Bigiani A,Roper SD

更新日期：1994-08-01 00:00:00

abstract：:The topographical distribution of sciatic and femoral nerve sensory neuronal somata in the L4 dorsal root ganglion of the adult rat was mapped after retrograde tracing with one or two of the dyes Fast Blue, Fluoro-Gold, or Diamidino Yellow. The tracers were applied to the proximal transected end of either nerve alone,...

journal_title：Neuroscience letters

authors： Puigdellívol-Sánchez A,Prats-Galino A,Ruano-Gil D,Molander C

更新日期：1998-07-31 00:00:00

abstract：:The aim of the present study is to investigate the effects of orphanin FQ (OFQ) microinjected into the nucleus raphe magnus (NRM) and the nucleus reticularis gigantocellularis (NGC) on pain modulation. The tail-flick latency (TFL) was used as a behavioral index of nociceptive responsiveness. The result showed microinj...

journal_title：Neuroscience letters

authors： Yang Z,Zhang Y,Wu G

更新日期：2001-06-22 00:00:00

abstract：:In the rat, unilateral dorsal cervicothoracic rhizotomy (C5-T2) resulted in autotomy of the ipsilateral limb. The onset of self-mutilation was variable and attained the maximum degree 8-9 weeks after the dorsal root section. Fifteen and 60 days after the lesion the monoamines dopamine (DA), noradrenaline (NA) and sero...

journal_title：Neuroscience letters

authors： Colado MI,Arnedo A,Peralta E,Del Río J

更新日期：1988-05-03 00:00:00

abstract：:Apoptotic cell death is associated with condensation and fragmentation of the nuclear chromatin into apoptotic bodies. Such nuclei occur frequently following cerebral hypoxia-ischemia in 1 week old rats but seem sparse in older animals. We investigated the age dependence by counting pyknotic or punctate chromatin cont...

journal_title：Neuroscience letters

authors： Sidhu RS,Tuor UI,Del Bigio MR

更新日期：1997-02-21 00:00:00

abstract：:The localisation of transforming growth factor-beta-2 (TGF-beta 2) in skeletal muscles was investigated with immunohistochemistry. In neonates, TGF-beta 2 was distributed throughout the muscle fibres but as the fibres matured TGF-beta 2 became restricted to the circumference of a small subpopulation of nuclei. These n...

journal_title：Neuroscience letters

authors： McLennan IS,Koishi K

更新日期：1994-08-15 00:00:00

abstract：:Lumbar spinal cord explants, harvested from neonatal rat pups aged between postnatal day 0 (P0) and P7, were cultured for a period of 48 h in the chemically defined medium R(12) [17] (Romijn, H.J., van-Huijen, F., Wolters, P.S., Neurosci Biobehav Rev, 8 (1984) 301-334), embedded in a collagen matrix. The outgrowth int...

journal_title：Neuroscience letters

authors： Mouveroux JM,Lakke EA,Marani E

更新日期：2001-09-28 00:00:00

abstract：:Leucine-rich glioma inactivated 3 (LGI3) is a member of LGI/epitempin (EPTP) family. The biological function of LGI3 and its association with disease are not known. We previously reported that mouse LGI3 was highly expressed in brain in a developmentally and transcriptionally regulated manner. In this study, we identi...

journal_title：Neuroscience letters

authors： Park WJ,Lee SE,Kwon NS,Baek KJ,Kim DS,Yun HY

更新日期：2008-10-31 00:00:00

abstract：:The phenylquinoline, PK 8165 (5-25 mg/kg), produced dose-related reductions in locomotor activity, rearing and exploratory head-dipping in a holeboard. Neither Ro 15-1788 (1, 10 or 20 mg/kg) nor CGS 8216 (1 or 10 mg/kg) was able to reverse the reductions in locomotor activity or rearing. This suggests that at least so...

journal_title：Neuroscience letters

authors： File SE,Pellow S

更新日期：1984-09-07 00:00:00

abstract：:Preterm infants undergo several painful procedures during their stay in neonatal intensive care units. Previous studies suggest that early painful experiences may have an impact on brain development. Here, we used an animal model to investigate the effect of neonatal pain on the generation of new neurons in the dentat...

journal_title：Neuroscience letters

authors： Leslie AT,Akers KG,Martinez-Canabal A,Mello LE,Covolan L,Guinsburg R

更新日期：2011-08-26 00:00:00

abstract：:Expression levels of amyloid beta (Abeta)-degrading enzymes, insulin degrading enzyme (IDE) and neprilysin (NEP), were examined in transgenic mice with Alzheimer's disease-like neuropathology. After the development of first Abeta plaques in transgenic mice brain, cortical mRNA and protein levels of IDE were significan...

journal_title：Neuroscience letters

authors： Vepsäläinen S,Hiltunen M,Helisalmi S,Wang J,van Groen T,Tanila H,Soininen H

更新日期：2008-06-20 00:00:00

abstract：:Thermogenetics is a promising innovative neurostimulation technique, which enables robust activation of single neurons using thermosensitive cation channels and IR stimulation. The main advantage of IR stimulation compared to conventional visible light optogenetics is the depth of penetration (up to millimeters). Due ...

journal_title：Neuroscience letters

authors： Roshchin M,Ermakova YG,Lanin AA,Chebotarev AS,Kelmanson IV,Balaban PM,Zheltikov AM,Belousov VV,Nikitin ES

更新日期：2018-11-20 00:00:00

abstract：:We examined the association between endogenous opioid β-endorphin, cancer progression and pain in a transgenic mouse model of breast cancer, with a rat C3(1) simian virus 40 large tumor antigen fusion gene (C3TAg). C3TAg mice develop ductal epithelial atypia at 8 weeks, progression to intra-epithelial neoplasia at 12 ...

journal_title：Neuroscience letters

authors： Argueta DA,Aich A,Lei J,Kiven S,Nguyen A,Wang Y,Gu J,Zhao W,Gupta K

更新日期：2021-01-23 00:00:00

abstract：:Electrophysiological and biochemical studies have indicated that GABAergic modulation is involved in the opioid-induced altering of response properties of visual cortical cells and impairing of short-term synaptic plasticity in the geniculo-cortical visual pathway. The aim of the current study was to examine whether t...

journal_title：Neuroscience letters

authors： Li Y,He L,Chen Q,Zhou Y

更新日期：2007-11-20 00:00:00