Abstract:
:Expression levels of amyloid beta (Abeta)-degrading enzymes, insulin degrading enzyme (IDE) and neprilysin (NEP), were examined in transgenic mice with Alzheimer's disease-like neuropathology. After the development of first Abeta plaques in transgenic mice brain, cortical mRNA and protein levels of IDE were significantly up-regulated in the transgenic mice compared to their non-transgenic littermates. Up-regulation of IDE mRNA-levels occurred in parallel with increased Abeta40 and Abeta42 production. Additionally, a significant positive correlation was observed between protein levels of IDE and full-length amyloid precursor protein (APP) in the cerebral cortex. mRNA and protein levels of NEP were also nominally up-regulated in Tg mice compared to controls. These data may reflect up-regulation of the IDE and possibly of NEP expression in response to the Abeta accumulation.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Vepsäläinen S,Hiltunen M,Helisalmi S,Wang J,van Groen T,Tanila H,Soininen Hdoi
10.1016/j.neulet.2008.04.025subject
Has Abstractpub_date
2008-06-20 00:00:00pages
216-20issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(08)00504-1journal_volume
438pub_type
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