The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice.

abstract：:The effects of classical fear conditioning in different regions of the limbic system were analysed using cytochrome oxidase (CO) histochemistry. Wistar rats were submitted to different conditions. Rats in the group Paired received tone-shock pairing, to elicit conditioned suppression of lever pressing (i.e., tone will...

journal_title：Neuroscience letters

authors： Conejo NM,López M,Cantora R,González-Pardo H,López L,Begega A,Vallejo G,Arias JL

更新日期：2005-01-10 00:00:00

abstract：:The effect of the neuropeptide, substance P, on the transport of D-[(3)H]aspartate into rat striatal synaptosomes was studied. Almost 90% of the total transport of D-[(3)H]aspartate was sodium-dependent and the maximum rate (V(max)) of this transport was increased by 34% of control by 2.5 nM substance P (EC(50)=0.52 n...

journal_title：Neuroscience letters

authors： Healy J,Downes A,McBean GJ

更新日期：2000-08-25 00:00:00

abstract：:The volume density of mast cells was estimated in nerve end neuromas at various time-points after transection of the left sciatic nerve of 6-week-old mice. After an initial reduction in the amount of mast cells there was a steady increase with numerous cells in 6-month-old neuromas. The variation in amount of mast cel...

journal_title：Neuroscience letters

authors： Nennesmo I,Reinholt F

更新日期：1986-09-12 00:00:00

abstract：:The expression of neuronal type of nitric oxide synthase (nNOS) has been studied by immunocytochemistry in the brain of rats receiving a single daily (for up to 14 consecutive days) intracerebroventricular (i.c.v.) injection of the HIV-1 recombinant protein gp 120 (100 ng/day). This treatment failed to affect nNOS exp...

journal_title：Neuroscience letters

authors： Bagetta G,Corasaniti MT,Costa N,Berliocchi L,Finazzi-Agrò A,Nisticò G

更新日期：1997-03-14 00:00:00

abstract：:Maternal infection during pregnancy increases the risk of neurodevelopmental conditions such as autism spectrum disorders and schizophrenia in offspring. Several previous animal studies have indicated that maternal immune activation (MIA), rather than a specific pathogen, alters fetal brain development. Among them, pr...

journal_title：Neuroscience letters

authors： Zuiki M,Chiyonobu T,Yoshida M,Maeda H,Yamashita S,Kidowaki S,Hasegawa T,Gotoh H,Nomura T,Ono K,Hosoi H,Morimoto M

更新日期：2017-07-13 00:00:00

abstract：:The idiopathic scoliosis is characterized by a three-dimensional spinal deformity involving new dynamical strategies to regulate the posture. The aim is to analyze the centre of pressure (CP) behaviour in forward stepping (FS) and lateral stepping (LS) to determine the dynamical consequences of scoliosis. Ten adolesce...

journal_title：Neuroscience letters

authors： Bruyneel AV,Chavet P,Bollini G,Allard P,Mesure S

更新日期：2008-12-12 00:00:00

abstract：:Repetitive ischemia causes more severe damage than a single insult of comparable duration. Gerbils were followed for 1 month postrepetitive ischemia and 100% mortality was demonstrated in the unprotected ischemia group by 12 days postischemia. Significant protection against mortality due to repetitive ischemia was off...

journal_title：Neuroscience letters

authors： McCrea S,Shuaib A,Wishart T,Ijaz S

更新日期：1994-03-28 00:00:00

abstract：:The effect of PD-168077 (N-methyl-4-(2-cyanophenyl)piperazynil-3-methylbenzamide maleate), a selective D4 dopamine receptor agonist, injected into the paraventricular nucleus of the hypothalamus on penile erection was studied in male rats. PD-168077 (1-200 ng) induced penile erection in a dose-dependent manner. The mi...

journal_title：Neuroscience letters

authors： Melis MR,Succu S,Mascia MS,Argiolas A

更新日期：2005-04-29 00:00:00

abstract：:A digoxigenin-labeled antisense 42-mer oligonucleotide was used for the localization of the dopamine D2 receptor mRNA in the rat brain. The digoxigenin label was identified with alkaline phosphatase conjugated sheep-anti-digoxigenin. In good analogy with the known terminal fields of the dopaminergic system, various nu...

journal_title：Neuroscience letters

authors： Brouwer N,Van Dijken H,Ruiters MH,Van Willigen JD,Ter Horst GJ

更新日期：1992-08-17 00:00:00

abstract：:Cultures were produced from retinas taken from human foetuses. Specific cells in culture have the capacity to take up exogenous serotonin, which was then visualized by immunofluorescence using an antisera to serotonin. The known serotonergic uptake blocker, chlorimipramine, inhibited the uptake of the amine while benz...

journal_title：Neuroscience letters

authors： Osborne NN,Beaton DW

更新日期：1985-04-09 00:00:00

abstract：:Human amniotic epithelial (HAE) cells have been used for allotransplantation in patients with lysosomal storage disease due to lack of expression of HLA antigens. Previously, we have reported the expression of differentiation markers for both neural stem cells, and neuron and glial cells. In the present study, we inve...

journal_title：Neuroscience letters

authors： Sakuragawa N,Misawa H,Ohsugi K,Kakishita K,Ishii T,Thangavel R,Tohyama J,Elwan M,Yokoyama Y,Okuda O,Arai H,Ogino I,Sato K

更新日期：1997-08-22 00:00:00

abstract：:We have tested the hypothesis that referred pain of pelvic viscera is elicited by dichotomizing branches of unmyelinated primary afferents projecting via the pelvic nerve to the viscera and through the pudendal nerve to the perineum where pelvic pain is commonly referred to. Using neurophysiological techniques 588 unm...

journal_title：Neuroscience letters

authors： Häbler HJ,Jänig W,Koltzenburg M

更新日期：1988-11-22 00:00:00

abstract：:We analyzed the participation of N-methyl-d-aspartate (NMDA) receptors in the neuronal damage caused by adult-onset hypothyroidism. Wistar rats were randomly assigned into four groups. The euthyroid group received tap water. The hypothyroid group received methimazole (60 mg/kg) in their drinking water to induce hypoth...

journal_title：Neuroscience letters

authors： Alva-Sánchez C,Becerril A,Anguiano B,Aceves C,Pacheco-Rosado J

更新日期：2009-04-10 00:00:00

abstract：:The purpose of this study was to measure the average anterior commissure (AC) volume of normal subjects in their 20s or 40s and to determine the effects of gender and age on AC volume. Magnetic resonance brain images were obtained for 93 people in their 20s (46 men, 47 women) and 87 in their 40s (36 men, 51 women). To...

journal_title：Neuroscience letters

authors： Choi MH,Kim JH,Yeon HW,Choi JS,Park JY,Jun JH,Lee BY,Kim HJ,Tack GR,Chung SC

更新日期：2011-08-15 00:00:00

abstract：:The epsilon4 allele of the apolipoprotein E gene (APOE) has repeatedly been associated with increased risk for Alzheimer's disease (AD). Bullido and colleagues recently identified a polymorphism in the promoter region of the APOE gene (-491A/T) and found that -491A homozygosity predicted AD independently of APOE epsil...

journal_title：Neuroscience letters

authors： Town T,Paris D,Fallin D,Duara R,Barker W,Gold M,Crawford F,Mullan M

更新日期：1998-08-14 00:00:00

abstract：:Mutations in the hairless (hr) gene of mice result in hair follicle and other epithelial defects. The hr gene is expressed at high levels in the brain where it probably participates in the survival and maintenance of some neuronal populations, but whether it also supports glial populations of the central nervous syste...

journal_title：Neuroscience letters

authors： San Jose I,García-Atares N,Pelaez B,Cabo R,Esteban I,Vega JA,Represa J

更新日期：2001-08-24 00:00:00

abstract：:To assess the neurotoxic properties of the glutamate agonist quisqualic acid (QA) in immature brain, we injected this compound (100 nmol QA/1 microliter) directly into the striatum of 7-day-old rats. QA produced neuronal necrosis and glial infiltration in 14 pups and reduced the size of the striatum and hippocampus on...

journal_title：Neuroscience letters

authors： Silverstein FS,Chen R,Johnston MV

更新日期：1986-10-30 00:00:00

abstract：:To identify choline acetyltransferase (ChAT) transcript(s) in human foetal brain we used the reverse polymerase chain reaction including different couples of oligonucleotide primers. The analysis indicated the presence of a new choline acetyltransferase transcript containing at its 5' end an untranslated exon (E1A) of...

journal_title：Neuroscience letters

authors： Schmitt M,Garnier JM,Simoni P,Quirin-Stricker C

更新日期：1994-09-12 00:00:00

abstract：:Parkin is a ubiquitin ligase involved in the ubiquitin-proteasome system. Elevating parkin expression in cells reduces markers of oxidative stress while blocking parkin expression increases oxidative stress. In parkin gene knock down mouse and fly models, mitochondria function is deficient. Parkin is neuroprotective a...

journal_title：Neuroscience letters

authors： Klein RL,Dayton RD,Henderson KM,Petrucelli L

更新日期：2006-06-19 00:00:00

abstract：:The purpose of this study was to examine the effects of intraplantar dexmedetomidine to relieve neuropathic pain and determine the role of peripheral α2-adrenoceptors. Neuropathic pain was induced by ligating the L5 and L6 spinal nerves in male Sprague-Dawley rats, and mechanical allodynia was assessed using von Frey ...

journal_title：Neuroscience letters

authors： Lee HG,Choi JI,Kim YO,Yoon MH

更新日期：2013-12-17 00:00:00

abstract：:Parkinson's disease (PD) may be initiated or precipitated by endogenous toxins with a structure similar to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in genetically-predisposed individuals. Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions. Th...

journal_title：Neuroscience letters

authors： Aoyama K,Matsubara K,Kondo M,Murakawa Y,Suno M,Yamashita K,Yamaguchi S,Kobayashi S

更新日期：2001-01-26 00:00:00

abstract：:Ifenprodil is an atypical N-methyl-D-aspartate (NMDA) receptor antagonist that selectively blocks receptors containing the NR2B subunit. It has been proposed that ifenprodil may act at a stimulatory polyamine site on NMDA receptors, although interactions between ifenprodil and polyamines are non-competitive. NMDA rece...

journal_title：Neuroscience letters

authors： Pahk AJ,Williams K

更新日期：1997-03-28 00:00:00

abstract：:Parkinson's disease (PD) is one of the common neurodegenerative diseases that result in the progressive damage of dopaminergic neurons. Environmental exposure, including paraquat, is considered risky for PD. Epigenetics refer to the study of heritable changes in gene expression that occur without a change in DNA seque...

journal_title：Neuroscience letters

authors： Kong M,Ba M,Liang H,Ma L,Yu Q,Yu T,Wang Y

更新日期：2012-08-22 00:00:00

abstract：:Cationic liposomes are commonly used to introduce foreign genes to the target cells. However, the methods are not applicable to several types of cells such as neuronal cells. We introduced the luciferase gene to the neuronal pheochromocytoma-12 (PC12) cells by cationic liposomes with a cationic cholesterol derivative ...

journal_title：Neuroscience letters

authors： Noguchi A,Hirashima N,Furuno T,Nakanishi M

更新日期：2002-05-31 00:00:00

abstract：:Systemic administration of S18986, a positive allosteric modulator of AMPA receptors, improves cognition. The present study further characterizes the drug's memory-enhancing properties and is the first to investigate its intracerebral effects on learning and memory. The results showed that rats receiving a single dose...

journal_title：Neuroscience letters

authors： Yefimenko N,Portero-Tresserra M,Martí-Nicolovius M,Guillazo-Blanch G,Vale-Martínez A

更新日期：2013-08-26 00:00:00

abstract：:The neuropathological hallmarks of Alzheimer's disease (AD) include the presence of extracellular amyloid-beta peptide (Abeta) in the form of amyloid plaques in the brain parenchyma and neuronal loss. The mechanism associated with neuronal death by amyloid plaques is unclear but oxidative stress and glial activation h...

journal_title：Neuroscience letters

authors： Lee HJ,Lee JK,Lee H,Shin JW,Carter JE,Sakamoto T,Jin HK,Bae JS

更新日期：2010-08-30 00:00:00

abstract：:To assess cortical activity during pain perception, regional cerebral blood flow (rCBF) studies were done in humans using single photon emission computed tomography (SPECT) with the radiotracer Tc99m-HMPAO and magnetic resonance imaging localization. Normalized SPECT data were analyzed by region of interest and change...

journal_title：Neuroscience letters

authors： Apkarian AV,Stea RA,Manglos SH,Szeverenyi NM,King RB,Thomas FD

更新日期：1992-06-22 00:00:00

abstract：:Leucine-enkephalin-like immunoreactive (ENK-LI) afferent fibers to the feline homologue of the Onuf's nucleus (pudendal motoneurons) originate mainly from lamina X of the sacral cord. They make synaptic contacts chiefly upon dendrites of pudendal motoneurons; the synaptic terminals most often contain pleomorphic synap...

journal_title：Neuroscience letters

authors： Konishi A,Itoh K,Sugimoto T,Yasui Y,Kaneko T,Takada M,Mizuno N

更新日期：1985-10-24 00:00:00

abstract：:Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are neurodegenerative diseases that may share genetic risk factors. The exon variant Aal58Val (rs17571) in CTSD was recently associated with AD, leading us to examine whether it also affects risk of ALS and PD. The rs17571 varia...

journal_title：Neuroscience letters

authors： Xi J,Yang X,Zhao Q,Zheng J,An R,Tian S,Huang H,Hu F,Ning P,Xu Y

更新日期：2018-01-01 00:00:00

abstract：:The effect of bifemelane hydrochloride (BFH) on the induction of heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 mRNAs after transient global ischemia in gerbil brain was investigated by in situ hybridization using cloned cDNA probes selective for each mRNA species. Following 3.5 min of ischemia, H...

journal_title：Neuroscience letters

authors： Aoki M,Abe K,Liu XH,Lee TH,Kato H,Kogure K

更新日期：1993-05-14 00:00:00