Apolipoprotein(a) null phenotype is related to a delayed age at onset of Alzheimer's disease.

abstract：:Phencyclidine (PCP) is known to be an inhibitor of serotonin (5-HT) uptake and to increase serotonergic activity. The development of tolerance to serotonergic stereotyped behaviors induced by repeated PCP treatment and changes of 5-HT transporters were examined. Backpedalling was significantly reduced in frequency fol...

journal_title：Neuroscience letters

authors： Hori T,Abe S,Baba A,Suzuki T,Shiraishi H

更新日期：2000-02-11 00:00:00

abstract：:We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influ...

journal_title：Neuroscience letters

authors： Houlden H,Rizzu P,Stevens M,de Knijff P,van Duijn CM,van Swieten JC,Heutink P,Perez-Tur J,Thomas V,Baker M,Morris H,Rossor M,Jannsen JC,Petersen RC,Dodd P,Dark F,Boeve B,Dickson D,Davies P,Pickering-Brown S,Mann D

更新日期：1999-02-05 00:00:00

abstract：:A comparison of cholecystokinin (CCK) receptor binding to sections of rat, mouse and guinea pig brain has been performed using 125I-Bolton Hunter CCK and the selective peripheral CCK receptor antagonist L-365,031. In both rat and mouse, 125I-Bolton Hunter CCK binding in the region of the interpeduncular nucleus (IPN) ...

journal_title：Neuroscience letters

authors： Hill DR,Shaw TM,Woodruff GN

更新日期：1987-08-31 00:00:00

abstract：:The biological clock of the suprachiasmatic nuclei drives numerous physiological and behavioural circadian rhythms. In this study, we addressed the question as to whether different components of the clock may control separately various circadian functions. Using the rat transpineal microdialysis tool, we analysed the ...

journal_title：Neuroscience letters

authors： Tritschler L,Saboureau M,Pévet P,Bothorel B

更新日期：2006-03-20 00:00:00

abstract：:During neuromuscular development, the nerve induces the expression of acetylcholine receptor (AChR) epsilon-subunit gene selectively in synaptic myonuclei. Here we show that even after elimination of neural effects by denervation, synaptic expression of epsilon-subunit transcripts is maintained for > 4 months. In cont...

journal_title：Neuroscience letters

authors： Herczeg A,Jones G,Brenner HR

更新日期：1995-06-23 00:00:00

abstract：:The time course of the event related potentials evoked within a delayed matching to sample task employing verbal and pictorial stimuli was analyzed with a source reconstruction method (minimum norm method). During signal stimulus presentation pictorial stimuli evoked more activity than verbal stimuli. Activity was par...

journal_title：Neuroscience letters

authors： Dobel C,Hauk O,Zobel E,Eulitz C,Pulvermüller F,Cohen R,Schönle PW,Elbert T,Rockstroh B

更新日期：1998-09-11 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor-induced inhibition of muscarinic receptor-stimulated phosphoinositide turnover in guinea pig cerebral cortical slices was investigated to determine whether polyamines regulate the function of NMDA in this system. None of the polyamines tested produced significant stimulation of...

journal_title：Neuroscience letters

authors： Alexander SP,Hill SJ,Kendall DA

更新日期：1991-10-14 00:00:00

abstract：:The most current human-based studies in which brain-derived neurotrophic factor (BDNF) levels in the peripheral blood system are analyzed use it as an indicator that represents BDNF levels in the CNS. However, whether circulating BDNF (serum and plasma) is positively or inversely associated with cardiorespiratory fitn...

journal_title：Neuroscience letters

authors： Cho HC,Kim J,Kim S,Son YH,Lee N,Jung SH

更新日期：2012-06-21 00:00:00

abstract：:Mutations in DJ-1 cause familial Parkinson's disease (PD). The expression pattern of DJ-1 in the brain remains controversial. In the present study, we used DJ-1 deficient mice as negative controls and examined DJ-1 mRNA expression in mouse brains. In sequential double labeling on the same sections, in situ hybridizati...

journal_title：Neuroscience letters

authors： Xie Z,Zhuang X,Chen L

更新日期：2009-11-20 00:00:00

abstract：:The central projections of axotomized fibers were assessed to investigate how well these matched the modality of the reinnervated receptor. Our results using intrafiber injection of horseradish peroxidase (HRP) and cord dorsum potentials evoked by intracellular stimulation of single afferents indicate that regeneratin...

journal_title：Neuroscience letters

authors： Koerber HR,Seymour AW,Mendell LM

更新日期：1989-04-24 00:00:00

abstract：:Post-stroke 'pushing' behaviour appears to be caused by impaired perception of vertical in the roll plane. While pushing behaviour typically resolves with stroke recovery, it is not known if misperception of vertical persists. The purpose of this study was to determine if perception of vertical is impaired amongst str...

journal_title：Neuroscience letters

authors： Mansfield A,Fraser L,Rajachandrakumar R,Danells CJ,Knorr S,Campos J

更新日期：2015-03-17 00:00:00

abstract：:kappa-Opioid receptors were radiolabelled with the peptides [125I]dynorphin(1-8) and [3H]dynorphin(1-8) or with [3H]etorphine on guinea pig forebrain and cerebellar sections and visualized by quantitative autoradiography. All three radioligands yielded similar patterns of kappa-receptor localization. However, quantita...

journal_title：Neuroscience letters

authors： Sharif NA,Hunter JC,Hill RG,Hughes J

更新日期：1988-04-12 00:00:00

abstract：:We carried out an immunohistochemical investigation of the spinal cords of 15 patients with sporadic amyotrophic lateral sclerosis (ALS), using antibodies to inducible nitric oxide synthase (iNOS) and nitrotyrosine; our purpose was to search for a possible role of increased oxidative damage in the motor system that ma...

journal_title：Neuroscience letters

authors： Sasaki S,Shibata N,Komori T,Iwata M

更新日期：2000-09-08 00:00:00

abstract：:Rats become susceptible to audiogenic seizures (AS) when they are exposed to intense noise during a certain critical period of development (priming). Antagonism of N-methyl-D-aspartate (NMDA) receptor NR2B subunit by injecting an antagonist ifenprodil at priming enhanced the later susceptibility to AS. An weak NR2A an...

journal_title：Neuroscience letters

authors： Hironaka N,Niki H

更新日期：2000-07-14 00:00:00

abstract：:Bilateral, radiofrequency destruction of the hypothalamic paraventricular nucleus resulted in a pronounced depression in levels of immunoreactive (ir-) vasopressin (VP) in the medulla-pons of rats. The contents of ir-dynorphin1-17 (DYN), ir-DYN1-8 and ir-alpha-neo-endorphin (alpha-NE) therein were not, in contrast, af...

journal_title：Neuroscience letters

authors： Millan MH,Millan MJ,Herz A

更新日期：1982-12-30 00:00:00

abstract：:Olivary hypertrophy, a combined retrograde and transneuronal reaction, is found in cells of the inferior olive after cerebellar ablation in the cat. Its chief features are central chromatolysis and hypertrophy of the peripherally located granular endoplasmatic reticulum with accumulation of electron-dense material in ...

journal_title：Neuroscience letters

authors： Boesten AJ,Voogd J

更新日期：1985-10-24 00:00:00

abstract：:Comparable to the anti-craving compound acamprosate, caroverine reduces alcohol withdrawal symptoms by an antagonism at ionotropic glutamate receptors and a blockade of calcium channels. The present study examines the effect of caroverine in a craving model, in which acamprosate has proved effective before. A place av...

journal_title：Neuroscience letters

authors： Kratzer U,Schmidt WJ

更新日期：2003-10-02 00:00:00

abstract：:We investigated the effects of a weak cutaneous stimulus applied to the digital nerves (prepulse) on the masseter inhibitory reflex (MIR) to electrical stimulation of the mental nerve in nine healthy volunteers. The prepulse stimulus, which had no direct effect on the masseter muscle EMG activity, induced a significan...

journal_title：Neuroscience letters

authors： Gómez-Wong E,Valls-Solé J

更新日期：1996-04-26 00:00:00

abstract：:Optic fibre regeneration in young Xenopus was studied by [(3)H]proline autoradiography and by mapping the visuotectal projection electrophysiologically from 5 to 210 days after sectioning the right optic nerve. Regenerated optic fibers were demonstrated morphologically both in the contra and ipsilateral tecta. In cont...

journal_title：Neuroscience letters

authors： Glastonbury J,Straznicky K

更新日期：1978-01-01 00:00:00

abstract：:The present study aimed at investigating how a specific instruction concerning gaze orientation, which involved active head motion, could influence the performance of human subjects in a self-controlled whole-body rotation task in the dark. Subjects were seated on a mobile robotic chair that they controlled using a jo...

journal_title：Neuroscience letters

authors： Siegler I,Israël I

更新日期：2002-11-22 00:00:00

abstract：:The aims of the present work were to evaluate the exploratory activity in Sprague-Dawley rats, as well as to analyze the nigral and striatal mRNA expression of the plasticity-related genes bdnf and arc after L-buthionine sulfoximine (BSO) injection into substantia nigra compacta. Lesioned rats traveled less distance i...

journal_title：Neuroscience letters

authors： Díaz-Hung ML,Ruiz-Fuentes JL,Díaz-García A,León-Martínez R,Alberti-Amador E,Pavón-Fuentes N,Blanco-Lezcano L

更新日期：2018-11-20 00:00:00

abstract：:We have previously shown that P7 rat pups injected with the N-methyl-d-aspartate receptor (NMDAR) blocker MK801 displayed robust apoptotic injury within hours after injection. Further studies from our lab suggest that loss of calcium cannot be compensated for when vulnerable neurons lack calcium buffering capabilities...

journal_title：Neuroscience letters

authors： Turner CP,Debenedetto D,Liu C

更新日期：2009-02-06 00:00:00

abstract：:Changes in von Frey hair perception, pricking pain, and vibration thresholds were examined in six healthy human adults, in the zone of secondary hyperalgesia, 45 min following the topical application of capsaicin at concentrations of 0.05 and 0.1 mg/ml. In two of these subjects, cutaneous blood flow was monitored at 1...

journal_title：Neuroscience letters

authors： Andrews K,Baranowski A,Kinnman E

更新日期：1999-04-30 00:00:00

abstract：:Mice were treated with N-2-chloroethyl-N-ethyl-2-bromobenzylamine hydrochloride (DSP4), which causes severe noradrenaline (NA) depletions in brain regions and the spinal cord, or vehicle i.p. They were tested 14 days later for antinociception induced by intrathecal injections of different doses of NA. A potentiation o...

journal_title：Neuroscience letters

authors： Post C,Arweström E,Minor BG,Wikberg JE,Jonsson G,Archer T

更新日期：1985-08-16 00:00:00

abstract：:Febrile seizures (FS) are generally defined as seizures taking place during fever. Long-term prognosis, including development of epilepsy and malformation of cognitive function, has been demonstrated after infantile FS. However, the mechanism that triggers seizures in hyperthermic environment is still unclear. We here...

journal_title：Neuroscience letters

authors： Feng B,Tang YS,Chen B,Dai YJ,Xu CL,Xu ZH,Zhang XN,Zhang SH,Hu WW,Chen Z

更新日期：2014-10-03 00:00:00

abstract：:In an isolated preparation which consists of the buccal ganglia and the salivary nerve of Helix lucorum, neuron B2 can be identified by simultaneously recording the soma spike intracellularly and the axon spike extracellularly from the peripheral salivary nerve. The convulsant drug pentylenetetrazol (PTZ) eliminates t...

journal_title：Neuroscience letters

authors： Maratou E,Theophilidis G

更新日期：1999-06-18 00:00:00

abstract：:Recently developed neuroanatomical staining methods utilizing transportable markers have made it possible to visualize individual, growing retinotectal axons in the chick embryo. In the present work, we used such methods to examine the behavior of mechanically deflected axons on the tectum. The deflection of axons was...

journal_title：Neuroscience letters

authors： Thanos S,Bonhoeffer F

更新日期：1986-12-03 00:00:00

abstract：:Telmisartan is an angiotensin II type 1 receptor blocker and partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). Here, we investigated the protective capacity of telmisartan against high glucose (HG)-elicited oxidative damage in PC12 cells. The activity of lactate dehydrogenase (LDH), NADPH o...

journal_title：Neuroscience letters

authors： Eslami H,Sharifi AM,Rahimi H,Rahati M

更新日期：2014-01-13 00:00:00

abstract：:The bidirectional transport of cargos along the thin axon is fundamental for the structure, function and survival of neurons. Defective axonal transport has been linked to the mechanism of neurodegenerative diseases. In this paper, we study the effect of the local axonal environment to cargo transport behavior in neur...

journal_title：Neuroscience letters

authors： Che DL,Chowdary PD,Cui B

更新日期：2016-01-01 00:00:00

abstract：:The inferior alveolar nerves (IAN) of young male Wistar rats (b.wt. greater than or equal to 200 g) were transected unilaterally, slightly proximal to the mandibular foramen under anesthesia with chloral hydrate (0.4 g/kg, i.p.). After various postoperative periods of time, the animals received horseradish peroxidase ...

journal_title：Neuroscience letters

authors： Takemura M,Sugimoto T,Wakisaka S,Akai M

更新日期：1990-01-01 00:00:00