Abstract：
:The N-methyl-D-aspartate (NMDA) receptor-induced inhibition of muscarinic receptor-stimulated phosphoinositide turnover in guinea pig cerebral cortical slices was investigated to determine whether polyamines regulate the function of NMDA in this system. None of the polyamines tested produced significant stimulation of phosphoinositide turnover. Neither spermine nor the substituted polyamine philanthotoxin-343 altered the inhibitory effect of NMDA. The simpler substituted polyamines N-(4-hydroxyphenylpropanoyl)-spermine and N-(4-hydroxyphenylacetyl)-spermine, however, antaganised the NMDA receptor inhibition of the muscarinic response with low affinity (Ki greater than or equal to 100 microM). Diethylenetriamine, a purported polyamine antagonist of the NMDA receptor, was without effect on the NMDA inhibitory response, as was ifenprodil, a structurally unrelated compound with reported antagonist capacity. In summary, therefore, we fail to observe polyamine regulation of the NMDA receptor mediating an inhibition of the muscarinic phosphoinositide turnover response in guinea pig cerebral cortical slices.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Alexander SP,Hill SJ,Kendall DAdoi
10.1016/0304-3940(91)90605-ssubject
Has Abstractpub_date
1991-10-14 00:00:00pages
167-70issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(91)90605-Sjournal_volume
131pub_type
杂志文章abstract：:Mounting evidence supports the association between a polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) and suicidal behaviour. Recently, a novel variant of the 5-HTTLPR L allele was identified. The previously unknown L(G) allele produced similar levels of gene expression to the S allele and mig...
journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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doi：10.1016/j.neulet.2010.07.026
更新日期：2010-09-27 00:00:00
abstract：:Nicotine and smoking have long been proved to play an important role in cognition and memory in the hippocampus. This effect is closely related to the gamma-aminobutyric acid (GABA)ergic system. Previous research has focused on functional and pharmacological aspects of nicotine's modulation activity. In this study, th...
journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2007-04-06 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.05.038
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2009-07-24 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2017-04-24 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2002-01-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1984-08-24 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1995-01-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章,评审
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1984-04-20 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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更新日期：2002-03-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2017-08-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1997-08-15 00:00:00
