Abstract：
:Idiopathic cervical dystonia (ICD) is a movement disorder often resulting in profound disability and pain. Treatment options include oral medications or other invasive procedures, whereas intractable ICD has been shown to respond to invasive (deep) brain stimulation. In the present blinded, placebo-controlled case study, transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) has been applied to a 54-year old patient with intractable ICD. Results showed that 15 Hz tACS had both immediate and cumulative effects in dystonic symptom reduction, with a 54% reduction in the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total score, and a 75% in the TWSTRS Pain Scale. These effects were persistent at 30-days follow-up. This is the first report to demonstrate a significant and lasting therapeutic effect of non-invasive electrical brain stimulation in dystonia.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Angelakis E,Liouta E,Andreadis N,Leonardos A,Ktonas P,Stavrinou LC,Miranda PC,Mekonnen A,Sakas DEdoi
10.1016/j.neulet.2012.11.007subject
Has Abstractpub_date
2013-01-15 00:00:00pages
39-43eissn
0304-3940issn
1872-7972pii
S0304-3940(12)01464-4journal_volume
533pub_type
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