Abstract：
:Several studies have reported the presence of methylphenidate (MPH) in effluents; however, its impacts on aquatic life are not yet well understood. Here, we investigated the effects of acute exposure on endocrine and behavioral stress responses to environmentally relevant concentrations of MPH in zebrafish. We show that MPH blunts the response of cortisol to stress in zebrafish. On the other hand, MPH stresses fish per se. Additionally, MPH seems to modulate anxiety-like behaviors. We conclude that the presence of MPH in aquatic environments can alter neuroendocrine and behavior responses, which might considerably impact fish survival and welfare.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Endres HC,da Rosa JG,Kabasele Kalala C,Barcellos HH,Bertol CD,Gil Barcellos LJ,Rossato-Grando LGdoi
10.1016/j.neulet.2017.04.039subject
Has Abstractpub_date
2017-05-22 00:00:00pages
114-117eissn
0304-3940issn
1872-7972pii
S0304-3940(17)30340-3journal_volume
650pub_type
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