First evidence that waterborne methylphenidate alters endocrine and behavioral stress responses in zebrafish.


:Several studies have reported the presence of methylphenidate (MPH) in effluents; however, its impacts on aquatic life are not yet well understood. Here, we investigated the effects of acute exposure on endocrine and behavioral stress responses to environmentally relevant concentrations of MPH in zebrafish. We show that MPH blunts the response of cortisol to stress in zebrafish. On the other hand, MPH stresses fish per se. Additionally, MPH seems to modulate anxiety-like behaviors. We conclude that the presence of MPH in aquatic environments can alter neuroendocrine and behavior responses, which might considerably impact fish survival and welfare.


Neurosci Lett


Neuroscience letters


Endres HC,da Rosa JG,Kabasele Kalala C,Barcellos HH,Bertol CD,Gil Barcellos LJ,Rossato-Grando LG




Has Abstract


2017-05-22 00:00:00












  • A subset of nociceptin/orphanin FQ receptor-expressing neurons in the anterior hypothalamic area, as revealed in mice with lacZ reporter gene.

    abstract::Nociceptin/orphanin FQ (N/OFQ) is an endogenous peptide agonist for the opioid receptor homolog, N/OFQ receptor, and serves for the central control of autonomic functions. Morphological details including the cell types that may account for such N/OFQ functions, however, remain unclear. By using X-gal histochemistry fo...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Houtani T,Ikeda M,Kase M,Sato K,Sakuma S,Kakimoto S,Ueyama T,Munemoto Y,Takeshima H,Sugimoto T

    更新日期:2003-01-02 00:00:00

  • Characterization of trkB immunoreactive cells in the intermediolateral cell column of the rat spinal cord.

    abstract::The objective of the present study was to characterize the trkB receptor immunoreactive (-ir) cells in the intermediolateral cell column (IML) of the upper thoracic spinal cord. Small trkB-ir cells (area=56.1+/-4.4 microm(2)) observed in the IML showed characteristics of oligodendrocytes and were frequently observed i...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: McCartney AM,Abejuela VL,Isaacson LG

    更新日期:2008-08-01 00:00:00

  • Dynamin protein in stroke and vascular dementia.

    abstract::Damage to sub-cortical white matter is a key substrate of vascular dementia (VaD) leading to deficits in executive function and cognitive processing speed. Dynamin1 is a 100 kDa protein, accounting for 0.4% of the total brain protein, and has a central role in many intracellular processes such as synaptic vesicle traf...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Mulugeta E,Vallortigara J,Francis PT,Hye A,Kalaria RN,Perry EK,Lovestone S,Ballard CG

    更新日期:2014-03-20 00:00:00

  • Protein profiling of Guillain-Barrè syndrome cerebrospinal fluid by two-dimensional electrophoresis and mass spectrometry.

    abstract::Protein profiling of cerebrospinal fluid in Guillain-Barrè syndrome (GBS), an acute and immune-mediated disease affecting the peripheral nervous system, was performed by two-dimensional electrophoresis. Significant modulated spots in GBS patients vs. control groups (a group of multiple sclerosis patients and one of he...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: D'Aguanno S,Franciotta D,Lupisella S,Barassi A,Pieragostino D,Lugaresi A,Centonze D,D'Eril GM,Bernardini S,Federici G,Urbani A

    更新日期:2010-11-12 00:00:00

  • Effects of unilateral lesion of the nucleus basalis magnocellularis on carbachol- and serotonin-stimulated [3H]inositolmonophosphate accumulation in rat fronto-parietal cortex.

    abstract::We examined the effects of ibotenic acid induced unilateral lesion of the nucleus basalis magnocellularis (nBM) on carbachol- and serotonin-stimulated phosphoinositide (PI) breakdown in miniprisms obtained from rat fronto-parietal cortex 1 week following the lesion. Lesion-side muscarinic and serotoninergic receptor r...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Erfurth A,Holmes TC

    更新日期:1995-06-23 00:00:00

  • mRNA-directed cell-free myelin basic protein synthesis: no evidence of neuronal control.

    abstract::The specific mRNA of myelin basic protein (MBP) was isolated from active myelinating rat brains. The isolated mRNA was able to direct the synthesis of immunochemically detectable MBP in a wheat-germ cell free protein synthesis system. There was, however, no evidence of neuronal translational control of the in vitro MB...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Fan K

    更新日期:1982-03-17 00:00:00

  • Overexpression of nerve growth factor in epidermis of transgenic mice preserves excess sensory neurons but does not alter the somatotopic organization of cutaneous nerve projections.

    abstract::To determine how target-derived nerve growth factor (NGF) affects sensory neuronal survival and the development of topographic nerve projections in the spinal cord, anatomical studies were performed on transgenic mice that overexpress NGF in skin and other keratinized epithelial structures. Transgenic animals showed a...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Mendelson B,Albers KM,Goodness TP,Davis BM

    更新日期:1996-06-14 00:00:00

  • Sources and targets of nitric oxide in rat cerebellum.

    abstract::Nitric oxide (NO) mediates cell-cell signalling in the brain and stimulates cyclic GMP (cGMP) production in target cells. We have used NADPH-diaphorase (reduced nicotinamide adenine dinucleotide phosphate-diaphorase) histochemistry to identify NO-producing neurones and cGMP immunohistochemistry to locate the targets o...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Southam E,Morris R,Garthwaite J

    更新日期:1992-03-30 00:00:00

  • Genotype combinations for monoamine oxidase-B intron 13 polymorphism and dopamine D2 receptor TaqIB polymorphism are associated with ever-smoking status among men.

    abstract::Tobacco smoke inhibits monoamine oxidase-B (MAO-B) activity in vitro and in vivo, suggesting that MAO-B inhibition is a possible contributing factor to tobacco smoke addiction. Thus, MAO-B is a possible candidate gene for predisposition to smoking. The TaqIB polymorphism for the Dopamine D2 Receptor gene (DRD2) has be...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Costa-Mallen P,Costa LG,Checkoway H

    更新日期:2005-09-09 00:00:00

  • Somatostatin neurons form a distinct peptidergic neuronal group in the rat suprachiasmatic nucleus: a double labeling in situ hybridization study.

    abstract::Accumulating evidence indicates that somatostatin (SS) is a key substance for the circadian rhythm of rodents. In the present study, we investigated whether SS mRNA coexists with arginine-vasopressin (AVP) mRNA, vasoactive intestinal peptide/peptide histidine isoleucine amide (VIP/PHI) mRNA and glutamate decarboxylase...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Tanaka M,Okamura H,Matsuda T,Shigeyoshi Y,Hisa Y,Chihara K,Ibata Y

    更新日期:1996-09-06 00:00:00

  • Cortical frequency-specific plasticity is independently induced by intracortical circuitry.

    abstract::Auditory learning induces frequency-specific plasticity in the auditory cortex. Both the auditory cortex and thalamus are involved in the cortical plasticity; however, the precise role of the intracortical circuity remains unclear until the contributions of the thalamocortical inputs are controlled. Here, we induced c...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Kong L,Wang S,Liu X,Li L,Zeeman M,Yan J

    更新日期:2018-03-06 00:00:00

  • Motor cortex excitability in Alzheimer's disease: a transcranial magnetic stimulation follow-up study.

    abstract::Transient cognitive and behavioral stabilization of patients with Alzheimer's disease (AD) is the main goal of acetylcholinesterase inhibitor (AChEI) therapy. Response to treatment is variable and it is usually assessed clinically via neuropsychological scales. Functional neuroimaging could ideally permit the objectiv...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ferreri F,Pasqualetti P,Määttä S,Ponzo D,Guerra A,Bressi F,Chiovenda P,Del Duca M,Giambattistelli F,Ursini F,Tombini M,Vernieri F,Rossini PM

    更新日期:2011-04-01 00:00:00

  • Nitric oxide facilitates N-methyl-D-aspartate-induced burst firing in dopamine neurons from rat midbrain slices.

    abstract::Dopamine (DA) neurons in the ventral tegmental area and substantia nigra pars compacta were induced to fire in bursts with application of N-methyl-D-aspartate (NMDA, 20 microM) and apamin (100 nM) while recording intracellularly in the rat brain slice. L-Arginine (300 microM), a substrate for nitric oxide (NO) product...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Cox BA,Johnson SW

    更新日期:1998-10-23 00:00:00

  • Serum Brain-Derived Neurotrophic Factor Levels in Patients with Diabetic neuropathic pain.

    abstract:OBJECTIVE:Diabetic neuropathic pain (DNP) is one of the most common and severe complications in patients with diabetes. This study aimed to investigate serum brain-derived neurotrophic factor (BDNF) levels in patients with DNP and to evaluate the association between BDNF and disease severity. METHODS:A total of 143 T2...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Wang Z,Li H

    更新日期:2021-01-21 00:00:00

  • L-glutamate specific [3H]kainic acid binding in the rat neostriatum after degeneration of the cortico-striatal pathway.

    abstract::Four weeks after lesion of the cortico-striatal pathway, the specific kainic acid binding was reduced by 20% in the neostriatum. It is concluded that the binding sites are most likely not located on cortico-striatal neurons. The displacement of kainic acid by some chemical indicates that the kainic acid binding site i...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Henke H,Cuénod M

    更新日期:1979-03-01 00:00:00

  • ERP correlates of transposed-letter similarity effects: are consonants processed differently from vowels?

    abstract::Recent research has shown that pseudowords created by transposing letters are very effective for activating the lexical representation of their base words (e.g., relovution activates REVOLUTION). Furthermore, pseudoword transpositions of consonants are more similar to their corresponding base words than the transposit...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Carreiras M,Vergara M,Perea M

    更新日期:2007-06-04 00:00:00

  • 4-aminopyridine activates a cholinergic chloride conductance in isolated Helix neurons.

    abstract::Isolated Helix neurons were internally perfused under voltage-clamp, with drugs applied by the 'concentration clamp' which allowed an extremely rapid switching of the external solution. 4-Aminopyridine (4-AP) at more than 3 X 10(-4) M induced a chloride current (ICl) which could be blocked by D-tubocurarine. Acetylcho...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ikemoto Y,Akaike N,Ono K

    更新日期:1987-04-23 00:00:00

  • Corticotropin-releasing factor in the locus coeruleus mediates EEG activation associated with hypotensive stress.

    abstract::Although corticotropin-releasing factor (CRF) is thought to act as a neurotransmitter to activate the locus coeruleus (LC) during hypotensive stress, the consequences of LC activation by CRF are unknown. In the present study a hypotensive challenge that activated rat LC neurons also produced cortical electroencephalog...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Page ME,Berridge CW,Foote SL,Valentino RJ

    更新日期:1993-12-24 00:00:00

  • The cytoplasmic domain of the cell adhesion molecule L1 is not required for homophilic adhesion.

    abstract::L1 is a highly conserved cell adhesion molecule with complete homology of the cytoplasmic domain between the known mammalian protein sequences. Since the cytoplasmic domains of other adhesion molecules have been shown to influence adhesion, we have investigated the effects of deletion of the cytoplasmic domain on the ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Wong EV,Cheng G,Payne HR,Lemmon V

    更新日期:1995-11-24 00:00:00

  • The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing.

    abstract::Transient receptor potential channels have diverse roles in mechanosensation. Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing. Characteristic features of TRP channels include their high structural homology and their propensity to form heteromeri...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Sexton JE,Desmonds T,Quick K,Taylor R,Abramowitz J,Forge A,Kros CJ,Birnbaumer L,Wood JN

    更新日期:2016-01-01 00:00:00

  • Increased spinal dynorphin contributes to chronic nicotine-induced mechanical hypersensitivity in the rat.

    abstract::Chronic nicotine administration has been shown previously to produce mechanical hypersensitivity in the rat although the mechanism of this effect is unknown. Rats treated with chronic systemic nicotine 3.6 or 8.6 mg/(kg day) for 14-21 days displayed mechanical hypersensitivity coincident with an increase of prodynorph...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lough C,Young T,Parker R,Wittenauer S,Vincler M

    更新日期:2007-07-05 00:00:00

  • The 'M2' electromyographic response to random perturbations of arm movements is missing in long-trained monkeys.

    abstract::Adult monkeys who have been under training over a long period of time show a loss of the M2 component in their biceps electromyographic response to brief, random perturbations of an alternating arm movement, the M1 component being apparently enhanced. These changes of the stretch-induced responses indicate a long-term...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Christakos CN,Wolf H,Meyer-Lohmann J

    更新日期:1983-11-11 00:00:00

  • Inhibition of acid-sensing ion channels by chlorogenic acid in rat dorsal root ganglion neurons.

    abstract::Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in the human diet. Recently, it is demonstrated to have potent antinociceptive effect. However, little is understood about the mechanism underlying CGA analgesia. Here, we have found that CGA can exert an inhibitory effect on the functional activi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Qu ZW,Liu TT,Qiu CY,Li JD,Hu WP

    更新日期:2014-05-01 00:00:00

  • Brain activities of visual thinkers and verbal thinkers: A MEG study.

    abstract::In this study we measured activation patterns in the primary visual cortex and the frontal language areas and compared them in individuals with strong and weak capacities to mentally visualize information during spontaneous thinking. Subjects were first administered a 5-item questionnaire to assess their ability to cr...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Nishimura K,Aoki T,Inagawa M,Tobinaga Y,Iwaki S

    更新日期:2015-05-06 00:00:00

  • Cerebrospinal fluid apo E and apo A-I concentrations in early- and late-onset Alzheimer's disease.

    abstract::We compared cerebrospinal fluid (CSF) apolipoprotein (apo) A-I and apo E concentrations in early- and late-onset Alzheimer's disease (EOAD (n = 11), LOAD (n = 15), respectively) with those in control subjects (n = 23). CSF apo A-I levels in both EOAD and LOAD were consistent with control subjects. However, CSF apo E l...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Song H,Saito K,Seishima M,Noma A,Urakami K,Nakashima K

    更新日期:1997-08-15 00:00:00

  • Proteolytic processing of presenilin-1 in human lymphoblasts is not affected by the presence of the I143T and G384A mutations.

    abstract::Presenilin-1 (PSEN1) mutations I143T and G384A give rise to severe early onset Alzheimers's disease in two extensively studied Belgian families, AD/A and AD/B. In this study we investigated the influence of the I143T and G384A mutations on PSEN1 proteolytic processing. Hereto we analyzed PSEN1 processing in lymphoblas...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Vanderhoeven I,Cras P,Martin JJ,Van Broeckhoven C,De Jonghe C

    更新日期:1999-10-29 00:00:00

  • Human astrocytes and cytokines: tumor necrosis factor alpha and interferon gamma do not promote astrocytic proliferation.

    abstract::Astrocyte cell cultures were established from human fetal brains and exposed to human recombinant tumor necrosis factor alpha (TNF alpha) and human recombinant interferon gamma (IFN gamma), and the proliferative response was assessed by bromodeoxyuridine-immunostaining technique. TNF alpha showed an inhibitory activit...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Moretto G,Yoo A,Kim SU

    更新日期:1993-03-05 00:00:00

  • Neuroglobin protects against nitric oxide toxicity.

    abstract::Neuroglobin (Ngb) is a novel vertebrate globin expressed principally in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons against these insults. The mechanism of Ngb's protective action is unknown, but its ability to bind NO suggests that NO scavenging might be involved. To test this...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Jin K,Mao XO,Xie L,Khan AA,Greenberg DA

    更新日期:2008-01-10 00:00:00

  • Tannic acid alleviates lead acetate-induced neurochemical perturbations in rat brain.

    abstract::Oxidative stress has been projected as a promising mechanism involved in lead exposure. The lead predisposition catalyzes oxidative reactions and generates reactive oxygen species. The present study was carried out to investigate the effect of oral administration of tannic acid (TA) on behavioral deficit, antioxidativ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ashafaq M,Tabassum H,Vishnoi S,Salman M,Raisuddin S,Parvez S

    更新日期:2016-03-23 00:00:00

  • Pharmacological characterization of alpha 2-adrenoceptor regulated serotonin release in the rat hippocampus.

    abstract::The purpose of the present study was to confirm the functional regulation by alpha 2-adrenoceptors of the release of serotonin (5-HT) from the rat hippocampus in vivo. Under several pharmacological conditions, extracellular levels of 5-HT were estimated by assaying its concentrations in the perfusate by high performan...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Numazawa R,Yoshioka M,Matsumoto M,Togashi H,Kemmotsu O,Saito H

    更新日期:1995-06-16 00:00:00