Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid.

Abstract:

:We describe the measurement of beta-nerve growth factor (NGF) content in cerebrospinal fluid (CSF) from multiple sclerosis (MS) patients compared with CSF from age-matched normal subjects using a specific sandwich immunoassay (ELISA). During acute attacks patients exhibit a significant increase of NGF content compared to controls. In contrast during remission the mean NGF levels in CSF markedly decrease. These results strongly indicate that increased NGF production in CSF is a characteristic feature of the MS inflammatory response.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Laudiero LB,Aloe L,Levi-Montalcini R,Buttinelli C,Schilter D,Gillessen S,Otten U

doi

10.1016/0304-3940(92)90762-v

keywords:

subject

Has Abstract

pub_date

1992-11-23 00:00:00

pages

9-12

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(92)90762-V

journal_volume

147

pub_type

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